公开(公告)号：US07663748B2

公开(公告)日：2010-02-16

申请号：US11570132

申请日：2005-06-07

申请人： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

发明人： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

IPC分类号： G01J3/30

CPC分类号： G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

摘要： An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.

摘要翻译： 用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。 该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。 控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如， 毛细血管的中心。