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1.发明申请公开(公告)号：US20100298285A1
公开(公告)日：2010-11-25
申请号：US12225275
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/397 , C07D217/18 , C07D217/04 , C07D413/12 , A61K31/47 , A61K31/538 , A61P29/00 , A61P25/16 , A61P37/00 , A61P25/18 , A61P25/00 , A61P25/06 , A61P9/10 , A61P13/00 , A61P19/02 , A61P3/04 , A61P17/06 , A61P3/00 , A61P35/00
CPC分类号： C07D409/06 , C07D217/04 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US20110092476A1
公开(公告)日：2011-04-21
申请号：US12925297
申请日：2010-10-18
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： C07D217/24 , C07D215/20 , A61K31/47
CPC分类号： C07D217/24 , C07D401/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US20100292235A1
公开(公告)日：2010-11-18
申请号：US12225274
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/5377 , C07D217/24 , A61K31/47 , A61P29/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/18 , A61P25/22 , A61P25/08 , A61P13/08 , A61P13/10 , A61P11/06 , A61P19/02 , A61P9/10 , A61P17/04 , A61P17/06 , A61P3/04 , A61P35/00 , C07D413/06
CPC分类号： C07D217/22 , C07D217/24 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US07816371B2
公开(公告)日：2010-10-19
申请号：US11725153
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He, legal representative , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： C07D217/22 , A61K31/4704
CPC分类号： C07D217/24 , C07D401/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US20090298825A1
公开(公告)日：2009-12-03
申请号：US12225276
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/4725 , C07D401/04 , C07D413/14 , C07D413/04 , C07D217/24 , C07D453/02 , A61K31/472 , A61K31/5377 , A61P25/00 , A61P11/00 , A61P19/00
CPC分类号： C07D401/04 , C07D217/24 , C07D405/14 , C07D413/04 , C07D413/14 , C07D453/02
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有由下式表示的式的双杂芳基化合物：式（I）。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。
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公开(公告)号：US08093265B2
公开(公告)日：2012-01-10
申请号：US12075111
申请日：2008-03-07
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： C07D217/22 , A61K31/4704
CPC分类号： C07D217/24 , C07D401/04 , C07D401/06
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛 ，炎症，创伤性损伤等。
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公开(公告)号：US20100184802A1
公开(公告)日：2010-07-22
申请号：US12225340
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/4725 , C07D401/06 , C07D217/24 , A61K31/472 , A61P25/00 , A61P29/00 , A61P25/06 , A61P25/18 , A61P11/00 , A61P9/10 , A61P17/06 , A61P3/04 , A61P35/00 , A61P9/12
CPC分类号： C07D401/06 , C07D217/24
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US20080287415A1
公开(公告)日：2008-11-20
申请号：US12075111
申请日：2008-03-07
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/472 , C07D217/24 , C07D401/04 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07D217/24 , C07D401/04 , C07D401/06
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛 ，炎症，创伤性损伤等。
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公开(公告)号：US20070225324A1
公开(公告)日：2007-09-27
申请号：US11725153
申请日：2007-03-16
申请人： Michael Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/4704 , C07D217/22
CPC分类号： C07D217/24 , C07D401/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。
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公开(公告)号：US20110118287A1
公开(公告)日：2011-05-19
申请号：US11722514
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari
IPC分类号： A61K31/519 , C07D471/04 , C07D217/24 , A61K31/472 , C07D405/10 , A61K31/4725 , C07D405/06 , A61P29/00 , A61P17/02 , A61P25/00 , A61P35/00 , A61P9/10 , A61P9/12 , A61P11/00
CPC分类号： C07D217/24 , C07D401/06 , C07D405/06 , C07D405/10 , C07D471/04
摘要： Bicycloheteroaryl compounds are disclosed that have formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有式（I）的双杂杂芳基化合物。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。
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