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1.发明授权公开(公告)号：US07169161B2
公开(公告)日：2007-01-30
申请号：US10012891
申请日：2001-11-06
IPC分类号： A61M25/10
CPC分类号： A61M25/10184 , A61M25/09 , A61M25/10185 , A61M2025/09008
摘要： A tubular guidewire assembly having a distal occlusive device and an extended crimpable section proximate a proximal end that is adapted to connect to a gas inflation/evacuation system. The extended crimpable section can be selectively sealed at one of a plurality of separate locations to form an airtight seal of the tubular guidewire assembly. Each time a deflation of the occlusive device is desired in order to reestablish blood flow to a vessel downstream of the occlusive device, the extended crimpable section preferably is cut distal to the location of the last seal to quickly deflate the occlusive device.
摘要翻译： 一种管状导丝组件，其具有远端闭塞装置和靠近近端的伸缩卷曲部分，其适于连接到气体充气/抽空系统。 扩展的可卷曲部分可以选择性地密封在多个分开的位置中的一个处，以形成管状导丝组件的气密密封。 每次需要闭塞装置的放气以便重新建立到闭塞装置下游的血管的血液流动时，伸出的可卷曲部分优选地被切割到最后密封的位置的远侧，以快速地缩小闭塞装置。
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公开(公告)号：US20080312671A1
公开(公告)日：2008-12-18
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system including a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a nitinol hypotube, a flexible tip and distally located rearwardly directed orifices for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torquing and for longitudinal actuation along and within the vasculature.
摘要翻译： 一种输液流导丝系统，包括输送鞘和输注流导丝。 最小横截面柔性输注流导丝包括镍钛诺海波管，柔性尖端和向远侧定位的用于输注纤维蛋白溶解剂的向后的孔，并引入高压流体用于位于曲折的小尺寸血管中的浸渍和向后定向的血栓碎屑流。 提供其中一些可移除地附接的装置用于抓握本发明的构件用于旋转扭矩并沿着和在脉管系统内沿纵向致动。
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公开(公告)号：US08608703B2
公开(公告)日：2013-12-17
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system and method of use. The infusion flow guidewire system includes a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a flexible tip having a closed distal end, a coil, a core wire and at least one distally located jet orifice for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torqueing and for longitudinal actuation along and within the vasculature.
摘要翻译： 一种输液流导丝系统及其使用方法。 输注流导丝系统包括输送鞘和输注流导丝。 最小横截面柔性灌注流导丝包括柔性末端，其具有封闭的远端，线圈，芯线和用于输注纤维蛋白溶解剂的至少一个位于远端的喷射孔，并且用于引入用于浸渍和向后流动的高压流体 血栓碎片位于曲折的小型血管中。 提供了一些可拆卸地附接的装置，用于抓握本发明的构件以用于旋转扭矩并沿着和在脉管系统内沿纵向致动。
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公开(公告)号：US20080275383A1
公开(公告)日：2008-11-06
申请号：US10910108
申请日：2004-08-02
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译： 一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。 在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动 围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料 血管
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公开(公告)号：US07220269B1
公开(公告)日：2007-05-22
申请号：US10702815
申请日：2003-11-06
申请人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
发明人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
IPC分类号： A61B17/3203 , A61B17/3207 , A61M25/14
CPC分类号： A61B17/22031 , A61B17/22032 , A61B17/221 , A61B17/32037 , A61B2017/22035 , A61B2017/22067 , A61B2017/2215
摘要： A thrombectomy catheter system with occluder and method of using same for removal of tissue, such as thrombus and the like, from a vessel in the body. Multiple catheters and an occluder-bearing guidewire tube at a thrombus site provide for expandable deployment of a compliant occluder against the vasculature walls distal to the thrombus. The expanded occluder is maneuvered proximally to urge thrombus into close proximity with a retractable capture cone located distally on a capture catheter where the thrombus is dislodged, entrained, and broken into pieces by the action of a fluid jet emanator and then evacuated through the capture catheter.
摘要翻译： 具有闭塞器的血栓切除术导管系统及其用于从身体中的血管中去除组织（例如血栓等）的方法。 多个导管和位于血栓位置处的封堵器导丝管提供了将顺应性封堵器可扩展地部署在远离血栓的脉管系统壁上。 扩张的闭塞器在近侧被操纵以促使血栓紧邻位于远端位于捕获导管上的可伸缩捕获锥体，其中血栓被移出，夹带并通过流体喷射发生器的作用而分裂成碎片，然后通过捕获导管抽真空 。
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公开(公告)号：US07572244B2
公开(公告)日：2009-08-11
申请号：US10910108
申请日：2004-08-02
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译： 一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。 在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动 围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料 血管
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公开(公告)号：US06755803B1
公开(公告)日：2004-06-29
申请号：US09888455
申请日：2001-06-25
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.
摘要翻译： 单个操作者交换流体喷射血栓切除装置，其具有外导管组件和内导管组件形式的可分离和可更换组件，其允许作为溶血性血栓切除术导管或横流血栓切除术导管。 实施例包括与任何使用模式共同的外导管组件，其具有具有内腔的引导导管，引导线和携带导流器的下管的较大部分通过该内腔通过并前进。 为了用作溶解性血栓切除术导管，血栓被移出，夹带并通过射流破碎成碎片，并通过导管的内腔排出。 为了用作横流血栓切除术导管，提供了具有流出和流入孔的导流器。
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公开(公告)号：US07879022B2
公开(公告)日：2011-02-01
申请号：US11096592
申请日：2005-04-01
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/3203 , A61B2017/00292 , A61B2017/00778 , A61B2017/22041 , A61B2090/034
摘要： A rapid exchange fluid jet thrombectomy device having a streamlined manifold and a catheter having multiple tubular segments where each tubular segment increases in flexibility in a distal direction. Torque response and pushability is enhanced by the arrangement of a proximally located tubular segment composed of a polymer-jacketed spiral metal tube in combination with an intermediate tubular section and a distal tubular section each having different degrees of flexibility. A guidewire tube exit region is provided where the intermediate tubular section joins the distal tubular section for over-the-wire guidewire usage. The polymer-jacketed spiral metal tube can extend along a partial or full length of the catheter and can include a basic continuous spiral cut which has regions of constant pitch or which has progressively increasing pitch, or in the alternative, can include an interlocking spiral cut having constant pitch regions or progressively decreasing pitch.
摘要翻译： 具有流线型歧管的快速交换流体喷射血栓切除装置和具有多个管状区段的导管，其中每个管状区段在远端方向上的柔性增加。 通过由聚合物夹套的螺旋金属管组成的近端定位的管状部分与中间管状部分和每个具有不同柔性程度的远端管状部分的组合来增强扭矩响应和推动性。 提供导丝管出口区域，其中中间管状部分连接远端管状部分用于线上导丝使用。 聚合物套管的螺旋金属管可以沿着导管的部分或全长延伸，并且可以包括具有恒定节距或具有逐渐增加的间距的区域的基本连续螺旋切口，或者替代地，可以包括互锁螺旋切口 具有恒定的音调区域或逐渐减小音调。
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公开(公告)号：US20080275393A1
公开(公告)日：2008-11-06
申请号：US10925113
申请日：2004-08-24
申请人： Michael J. Bonnette , Hieu V. Le
发明人： Michael J. Bonnette , Hieu V. Le
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084
摘要： An isolation thrombectomy catheter system where thrombus, clotted material, or the like is isolated by distally and proximally placed inflated occlusive balloons sealing a portion of the vasculature for subsequent removal of thrombus by cross stream jets. An isolation catheter accommodates either a jet assembly for ablation of thrombus and for drug or medication delivery, or accommodates a drug delivery device for introduction of lysing fluids, drugs or medications to a thrombus site. Alternating of lysing fluid delivery and ablation can be incorporated for a combined thrombectomy effort.
摘要翻译： 隔离血栓切除术导管系统，其中血栓，凝块材料等通过远侧和近端放置的充气闭塞球隔离，密封一部分脉管系统，以便随后通过流动射流除去血栓。 隔离导管容纳用于消融血栓和用于药物或药物输送的射流组件，或者容纳用于将裂解液，药物或药物引入血栓部位的药物递送装置。 可以并入裂解液输送和消融的交替用于组合的血栓切除术。
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公开(公告)号：US06676637B1
公开(公告)日：2004-01-13
申请号：US09888454
申请日：2001-06-25
申请人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.
摘要翻译： 单个操作者交换流体喷射血栓切除术方法，其使用具有外部导管组件的单个操作者交换流体喷射血栓切除装置，以及允许作为溶血性血栓切除术导管或横流血栓切除术导管起作用的内部导管组件形式的可分离和可更换部件。 外导管组件对于任何使用模式都是共同的，并且包括具有内腔的引导导管，通过该导管将导丝和携带喷射发生器和导流器的下管的较大部分通过并前进。 在该方法中，通过流体射流将血栓移出，夹带并分裂成碎片，并通过引导导管的内腔排出。
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