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公开(公告)号：US20140080768A1
公开(公告)日：2014-03-20
申请号：US13622606
申请日：2012-09-19
IPC分类号： C07D213/74 , C07D405/12
CPC分类号： C07D213/74 , C07D235/18 , C07D405/12
摘要： The invention generally relates to Pro-Drugs of dihydroorotate dehydrogenase (DHODH) inhibitors and methods of use thereof. In certain embodiments, the invention provides a DHODH inhibitor compound including a cleavable functional group that increases bioavailability as compared to a form of the DHODH inhibitor without the functional group, rendering the former more suitable for therapeutic use.
摘要翻译： 本发明一般涉及二氢乳清酸脱氢酶（DHODH）抑制剂的前药物及其使用方法。 在某些实施方案中，本发明提供一种DHODH抑制剂化合物，其包含与不含官能团的DHODH抑制剂形式相比提高生物利用度的可切割官能团，使前者更适合于治疗用途。
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公开(公告)号：US20140024621A1
公开(公告)日：2014-01-23
申请号：US13555720
申请日：2012-07-23
IPC分类号： A61K31/44 , A61K31/4409 , C07F9/58 , A61K31/675 , A61P25/00 , A61K31/4433 , A61K31/655 , C07D213/74 , C07D213/76 , C07D213/75 , C07D405/12
CPC分类号： C07F9/58 , C07D213/72 , C07D213/74 , C07D213/75 , C07D213/76 , C07D405/12
摘要： The invention generally relates to aminopyridines and methods of use thereof. In certain embodiments, the invention provides an aminopyridine or a pharmaceutically-acceptable salt thereof, in which the aminopyridine or the salt thereof includes a cleavable functional group that substantially prevents extra-hepatic hydrolysis.
摘要翻译： 本发明一般涉及氨基吡啶及其使用方法。 在某些实施方案中，本发明提供氨基吡啶或其药学上可接受的盐，其中氨基吡啶或其盐包括基本上防止肝外水解的可切割官能团。
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公开(公告)号：US20140079757A1
公开(公告)日：2014-03-20
申请号：US13622700
申请日：2012-09-19
申请人： Michael J. Hudson , Alan Palmer
发明人： Michael J. Hudson , Alan Palmer
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K9/006 , A61K31/519 , A61K31/714
摘要： The invention generally relates to the preparation and use of consumable products for delivering a bioactive agent to an oral cavity of a mammal. In certain embodiments, the invention provides a consumable product that releases a bioactive agent within an oral cavity of a mammal, the product including a polymer matrix and one or more bioactive agents, in which the matrix is of a heterogeneous thickness.
摘要翻译： 本发明一般涉及用于将生物活性剂递送到哺乳动物口腔的消耗品的制备和使用。 在某些实施方案中，本发明提供了在哺乳动物的口腔内释放生物活性剂的消耗性产品，所述产品包括聚合物基质和一种或多种生物活性剂，其中所述基质具有不均匀的厚度。
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公开(公告)号：US20120253095A1
公开(公告)日：2012-10-04
申请号：US13075885
申请日：2011-03-30
申请人： John M. Wright , Michael J. Hudson
发明人： John M. Wright , Michael J. Hudson
CPC分类号： G21K1/046 , A61N2005/1096 , B22F3/093 , B22F2301/10 , B22F2301/20 , G06Q10/06 , G21K1/10
摘要： A patient-specific compensator is created from solid particulates on-site at a radiation treatment facility and then used there at that facility in conjunction with a radiation therapy machine to deliver radiation therapy to a cancer patient. After use, the compensator can be broken down into loose solid particulates at the facility, and another compensator can be created on-site at the facility from those particulates and used in the radiation treatment of a different cancer patient at the facility.
摘要翻译： 患者特异性补偿器由辐射治疗设施现场的固体颗粒产生，然后在该设施处与放射治疗机一起使用，以向癌症患者传送放射疗法。 使用后，补偿器可以在设施中分解为松散的固体颗粒，另外可以在设施现场从这些颗粒物上制造另一个补偿器，并用于在设施处的不同癌症患者的放射治疗。
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公开(公告)号：US20120253495A1
公开(公告)日：2012-10-04
申请号：US13077306
申请日：2011-03-31
申请人： JOHN M. WRIGHT , William Tomer , Michael J. Hudson
发明人： JOHN M. WRIGHT , William Tomer , Michael J. Hudson
CPC分类号： G06T17/20 , A61N5/103 , A61N2005/1096 , B33Y80/00 , G06T2210/41
摘要： A compensator is used with a radiation therapy machine to treat a cancer patient. A three-dimensional surface of the compensator is defined by obtaining a radiation dose requirement created by a treatment planning system associated with the radiation therapy machine and determining a plurality of grid elements based on that radiation dose requirement. At least one of a plurality of points on each of the plurality of grid elements is connected with at least one of the plurality of points on another one of the plurality of grid elements to form a representation of the three-dimensional compensator.
摘要翻译： 补偿器与放射治疗机一起用于治疗癌症患者。 补偿器的三维表面通过获得与放射治疗机相关联的治疗计划系统产生的辐射剂量要求并基于该辐射剂量要求确定多个网格元件来定义。 多个网格元件中的每一个上的多个点中的至少一个点与多个网格元素中的另一个上的多个点中的至少一个连接，以形成三维补偿器的表示。
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公开(公告)号：US20120221256A1
公开(公告)日：2012-08-30
申请号：US13341522
申请日：2011-12-30
CPC分类号： G01N33/4836 , G16C20/70
摘要： The invention relates to systems and methods for characterizing tissue biopsies, cells and organisms as a result of predictable responses to known compounds. A sensor is used to detect plurality of features indicative of physiological activity in response to the external. A vector quantity comprising a number of dimensions equal to a number of different features is derived from the signal output of said sensor array and compared to one or more reference values to generate a physiological ‘fingerprint’.
摘要翻译： 本发明涉及用于表征组织活检，细胞和生物体作为对已知化合物的可预测反应的结果的系统和方法。 传感器用于响应于外部来检测指示生理活动的多个特征。 从所述传感器阵列的信号输出导出包括等于多个不同特征的数量的矢量，并与一个或多个参考值进行比较以产生生理“指纹”。
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7.发明申请VALIDATING A COMPENSATOR FOR USE IN A RADIATION THERAPY MACHINE TO TREAT A CANCER PATIENT 有权验证放射治疗机器用于治疗癌症患者的补偿器公开(公告)号：US20120250824A1
公开(公告)日：2012-10-04
申请号：US13077456
申请日：2011-03-31
申请人： JOHN M. WRIGHT , William Tomer , Michael J. Hudson
发明人： JOHN M. WRIGHT , William Tomer , Michael J. Hudson
CPC分类号： A61N5/1071 , A61N2005/1096
摘要： A method of validating a compensator for use in a radiation therapy machine to treat a cancer patient involves determining a radiation treatment plan based on a compensator description file that includes data representative of an actual machined surface of the compensator. The plan includes operating parameters of the radiation therapy machine, and this plan is compared against actual radiation measurements taken during a non-patient test of the radiation therapy machine with the compensator mounted to the machine. If the comparison results in a match, the compensator is validated for use in the radiation therapy machine to treat the cancer patient.
摘要翻译： 验证用于放射治疗机器中用于治疗癌症患者的补偿器的方法包括基于补偿器描述文件确定辐射治疗计划，所述补偿器描述文件包括表示补偿器的实际加工表面的数据。 该计划包括放射治疗机的操作参数，并将该计划与放射治疗机的非病人测试期间用安装在机器上的补偿器进行的实际辐射测量进行比较。 如果比较结果匹配，则补偿器被验证用于放射治疗机器以治疗癌症患者。
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8.发明申请COMPOSITIONS INCLUDING A SODIUM CHANNEL BLOCKER AND A B VITAMIN MOLECULE AND METHODS OF USE THEREOF 审中-公开包含钠通道阻断剂和B维生素分子的组合物及其使用方法公开(公告)号：US20120058097A1
公开(公告)日：2012-03-08
申请号：US13224949
申请日：2011-09-02
IPC分类号： A61K31/519 , A61P25/18 , A61P25/28 , A61P25/04 , A61K31/675 , A61P25/00
CPC分类号： A61K31/519 , A61K31/53 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： The invention generally relates to compositions including a sodium channel blocker and a B vitamin molecule and methods of use thereof. In certain embodiments, the invention provides compositions that include a sodium channel blocker and a B vitamin molecule. In other embodiments, the invention provides methods for treating a subject having a psychological disorder, a neurological disorder, a neurodengerative disorder, and/or a disorder associated with pain involving administering to the subject a sodium channel blocker and a B vitamin molecule.
摘要翻译： 本发明一般涉及包含钠通道阻断剂和B维生素分子的组合物及其使用方法。 在某些实施方案中，本发明提供包含钠通道阻断剂和B维生素分子的组合物。 在其它实施方案中，本发明提供了治疗患有心理障碍，神经障碍，神经吸收障碍和/或与疼痛相关的疾病的受试者的方法，其涉及向受试者施用钠通道阻断剂和B维生素分子。
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9.发明授权Validating a compensator for use in a radiation therapy machine to treat a cancer patient 有权验证用于放射治疗机器的补偿器来治疗癌症患者公开(公告)号：US08477903B2
公开(公告)日：2013-07-02
申请号：US13077456
申请日：2011-03-31
申请人： John M. Wright , William Tomer , Michael J. Hudson
发明人： John M. Wright , William Tomer , Michael J. Hudson
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61N2005/1096
摘要： A method of validating a compensator for use in a radiation therapy machine to treat a cancer patient involves determining a radiation treatment plan based on a compensator description file that includes data representative of an actual machined surface of the compensator. The plan includes operating parameters of the radiation therapy machine, and this plan is compared against actual radiation measurements taken during a non-patient test of the radiation therapy machine with the compensator mounted to the machine. If the comparison results in a match, the compensator is validated for use in the radiation therapy machine to treat the cancer patient.
摘要翻译： 验证用于放射治疗机器中用于治疗癌症患者的补偿器的方法包括基于补偿器描述文件确定辐射治疗计划，所述补偿器描述文件包括表示补偿器的实际加工表面的数据。 该计划包括放射治疗机的操作参数，并将该计划与放射治疗机的非病人测试期间用安装在机器上的补偿器进行的实际辐射测量进行比较。 如果比较结果匹配，则补偿器被验证用于放射治疗机器以治疗癌症患者。
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公开(公告)号：US4599878A
公开(公告)日：1986-07-15
申请号：US601498
申请日：1984-04-18
CPC分类号： E01B31/08
摘要： The method and apparatus are for bending or straightening a material such as a rail. A simple form of the apparatus comprises two spaced contact members for contacting the rail, and a rail lifting member located between these points arranged to lift the rail between the two points, the lifting member being arranged to engage the head of the rail. A preferred method comprises applying a load to the material and, while the load is applied, continuously or periodically measuring the load applied and the displacement of the material relative to the datum, establishing from the measurements a load at which the plastic component of the total deformation measured is equal to the predetermined deformation from the datum, and then removing the load.
摘要翻译： 该方法和装置用于弯曲或矫直诸如轨道的材料。 该装置的简单形式包括用于接触轨道的两个间隔开的接触构件，以及位于两个点之间的轨道提升构件，该轨道提升构件被布置成在两个点之间提升轨道，提升构件设置成接合轨道的头部。 优选的方法包括对材料施加负载，并且在施加负载的同时连续地或周期性地测量所施加的负载和材料相对于基准的位移，从测量值建立总体上的塑料部件的负载 测量的变形量等于从基准面的预定变形，然后去除负载。
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