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公开(公告)号:US20190126067A1
公开(公告)日:2019-05-02
申请号:US16091515
申请日:2017-04-04
发明人: Holger Goebel , Isabel Huth
IPC分类号: A61N5/10
CPC分类号: A61N5/1031 , A61N5/103 , A61N5/1037 , A61N5/1039 , A61N5/1043 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1071 , A61N5/1077 , A61N2005/1087
摘要: In one embodiment, a method includes receiving treatment information relating to a treatment plan for proton- or ion-beam therapy intended to irradiate a target tissue; receiving machine-limitation information relating to one or more limitations of one or more machines involved in the proton- or ion-beam therapy; determining a time-optimized beam current for a proton or ion beam based on the treatment information and the machine-limitation information, wherein the time-optimized beam current minimizes the time required to deliver a required quantity of monitor units to one of a plurality of spots, wherein each of the plurality of spots is a particular area of the target tissue; and delivering the time-optimized beam current to the particular area.
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2.
公开(公告)号:US20190087688A1
公开(公告)日:2019-03-21
申请号:US15861691
申请日:2018-01-04
发明人: Syu-Jyun PENG , Cheng-Chia LEE , Huai-Che YANG
CPC分类号: G06K9/6224 , A61B5/055 , A61N5/1071 , A61N5/1084 , G06K9/3241 , G06K9/6223 , G06K2209/05 , G06T7/0014 , G06T7/11 , G06T7/168 , G06T7/174 , G06T7/38 , G06T2207/10088 , G06T2207/20221 , G06T2207/30016 , G06T2207/30096 , G06T2207/30101
摘要: The present disclosure provides a magnetic resonance (MR) image analysis method for a patient who underwent radiotherapy. The method includes the steps: receiving an MR image set of a patient and a dose map of a radiotherapy plan; converting the dose intensity distribution of the dose map into the relative spatial positions in the MR image set; selecting a radiation dose and a radiation exposure region, wherein the radiation exposure region has radiation intensity being equal to or higher than the radiation dose; using the radiation exposure region to determine a region of interest (ROI) in the MR image set; classifying the voxels inside the ROI of the MR image set into different clusters according to the grayscale values of the voxels inside the ROI; and calculating the volume or ratios of the different clusters inside the ROI. The present disclosure also provides a method for evaluating risks of radiotherapy.
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公开(公告)号:US20190022420A1
公开(公告)日:2019-01-24
申请号:US16139137
申请日:2018-09-24
发明人: Lasse Heikki TOIMELA , Janne NORD
IPC分类号: A61N5/10
CPC分类号: A61N5/1071 , A61N5/103 , A61N5/1031 , A61N5/1064 , A61N2005/1054 , A61N2005/1072
摘要: Systems, devices, and methods for quality assurance for verification of radiation dose delivery in arc-based radiation therapy devices using a 3D gamma evaluation method.
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公开(公告)号:US20180289984A1
公开(公告)日:2018-10-11
申请号:US15904571
申请日:2018-02-26
IPC分类号: A61N5/10 , H01J37/244 , H01J37/24
CPC分类号: A61N5/1064 , A61N5/1071 , A61N2005/1087 , H01J37/243 , H01J37/244 , H01J2237/24564 , H01J2237/2485
摘要: An assembly for preventing an overdose of a charged particle beam during therapy to a patient includes a pixelated detector apparatus and a controller. The controller includes, for each pixel: a current integrator circuit that converts the local measured current into a total local detected charge integrated from a start time, the integrator circuit outputting an integrator voltage that corresponds to the total local detected charge; and a discriminator circuit that compares the integrator voltage with a reference voltage, the reference voltage corresponding to a maximum acceptable dose for the patient. A logic circuit generates an overdose fault signal if, at any of the pixels, the integrator voltage is higher than the reference voltage.
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公开(公告)号:US20180235554A1
公开(公告)日:2018-08-23
申请号:US15958595
申请日:2018-04-20
申请人: Eric A Burgett
发明人: Eric A Burgett
CPC分类号: A61B6/08 , A61B6/032 , A61B6/488 , A61N5/1031 , A61N5/1049 , A61N5/1067 , A61N5/1071 , A61N2005/1094 , A61N2005/1097 , B33Y50/02 , B33Y80/00
摘要: A patient-specific, restraining device is fabricated directly from the patient's diagnostic images, (e.g. Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Ultrasound) fabricated by additive manufacturing techniques, also known as 3D printing, using an algorithm that directly translates the medical images into instructions for the 3D printer. The patient-specific restraining device incorporates dosimetry devices to allow for real-time, near real-time or after-the-fact measurement of delivered radiation at the entry and exit points on the body. Using a patient's medical images and dose planning software, patient-specific dose calculations allows for the calculation of the predicted dose for each location of entry and exit of the beam on the restraining device. This restraining device and method may be used to measure irradiation dosages in real time, adjust dosage levels based on such measurements, and then deliver more accurate and precise treatments during advanced treatment techniques.
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公开(公告)号:US10016618B2
公开(公告)日:2018-07-10
申请号:US15142000
申请日:2016-04-29
申请人: BAYER HEALTHCARE LLC
发明人: Alan D. Hirschman , Arthur E. Uber, III , David M. Reilly , John F. Kalafut , Frederick W. Trombley, III , Steven J. Remis , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths , Marc A. Mabie , Mark Trocki
IPC分类号: A61B6/00 , A61M36/06 , A61M36/08 , A61N5/10 , A61B6/03 , A61B6/04 , A61M5/172 , G06F19/00 , G21G4/08 , A61B6/10 , A61B5/055 , G21F5/015 , A61B5/0205 , A61B5/00 , A61M5/00 , A61M5/145 , A61M5/168 , A61M5/178
CPC分类号: A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
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公开(公告)号:US09990731B2
公开(公告)日:2018-06-05
申请号:US14994766
申请日:2016-01-13
CPC分类号: A61N5/1037 , A61B6/06 , A61N5/1047 , A61N5/1049 , A61N5/1071 , A61N5/1075 , A61N2005/1054 , A61N2005/1072 , A61N2005/1076 , G06K9/6267 , G06T7/0012 , G06T7/0016 , G06T7/20 , G06T2207/10016 , G06T2207/10116
摘要: An apparatus includes: a processor configured for obtaining a first image that corresponds with a first multi-leaf collimator (MLC) configuration, wherein the first image is generated when the MLC is stationary, obtaining a second image that corresponds with a second MLC configuration, wherein the second image is generated when the MLC and/or another component of a radiation machine is being operated to track a motion, and performing an analysis based at least in part on the first image and the second image to obtain a result; and a non-transitory medium for storing the result.
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8.
公开(公告)号:US20180133511A1
公开(公告)日:2018-05-17
申请号:US15851543
申请日:2017-12-21
发明人: James F. Dempsey
CPC分类号: A61N5/1064 , A61B5/055 , A61B5/4836 , A61B5/4848 , A61B5/4878 , A61N5/1048 , A61N5/1071 , A61N2005/1055 , G01R33/50
摘要: Edema in tissue of a patient undergoing a course of radiation therapy or treatment can be estimated based on one or more MRI measurements used to measure changes in fluid content of various tissues. A correlation between observed changes in edema and one or more delivered fractions of radiation can be used to drive one or more clinical actions. Methods, systems, articles of manufacture, and the like are described.
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9.
公开(公告)号:US20180104513A1
公开(公告)日:2018-04-19
申请号:US15293648
申请日:2016-10-14
申请人: Alan Sliski
发明人: Alan Sliski
IPC分类号: A61N5/10
CPC分类号: A61N5/1081 , A61N5/103 , A61N5/1043 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1071 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087
摘要: An integrated system for radiation therapy that includes a synchrotron ion accelerator beam delivery system, and imaging system on the same compact rotating gantry is disclosed. An ion accelerator, accelerating charged particles, is mounted on an annular gantry that rotates about the patient to be treated. The charged particles may be protons or other heavier ions such as helium or carbon. The beam delivery system, which includes bending, focusing, and scanning magnets and other equipment for accurately delivering the ion beam to the patient, is integrated on the same rotating structure. An imaging system which in one embodiment is, but not limited to, a cone beam CT system. The accelerator and imaging system may be configured in a coplanar or non-coplanar arrangement with the rotation plane of the gantry and with the beam delivery system to allow for optimization of the size or functionality of the system.
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公开(公告)号:US09878180B2
公开(公告)日:2018-01-30
申请号:US14802879
申请日:2015-07-17
CPC分类号: A61N5/1071 , A61B6/54 , A61N5/103 , A61N5/1048 , A61N2005/1087 , G01N23/02
摘要: Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy.
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