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公开(公告)号：US20060063758A1
公开(公告)日：2006-03-23
申请号：US11272207
申请日：2005-11-10
申请人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： A61K31/55 , A61K31/4709 , C07D401/02
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译： 式I化合物
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公开(公告)号：US20060148794A1
公开(公告)日：2006-07-06
申请号：US11376976
申请日：2006-03-16
申请人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4709
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译： 式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1， 具有权利要求1给出的意义的化合物可以以用于治疗或预防关节炎，心血管疾病，糖尿病，肾功能衰竭，饮食失调的药物制剂的形式使用， 肥胖。
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公开(公告)号：US06787558B2
公开(公告)日：2004-09-07
申请号：US10247009
申请日：2002-09-19
申请人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： C07D40104
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译： 式I的化合物以及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1和A 2具有权利要求1中给出的含义，可用于 用于治疗或预防关节炎，心血管疾病，糖尿病，肾衰竭，进食障碍和肥胖症的药物制剂的形式。
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公开(公告)号：US07012073B2
公开(公告)日：2006-03-14
申请号：US10896445
申请日：2004-07-22
申请人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： C07D401/04 , C07D401/14 , A61K31/55 , A61K31/4709 , A61P3/04
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译： 式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1， 具有权利要求1给出的意义的化合物可以以用于治疗或预防关节炎，心血管疾病，糖尿病，肾功能衰竭，饮食失调的药物制剂的形式使用， 肥胖。
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公开(公告)号：US07166589B2
公开(公告)日：2007-01-23
申请号：US11376976
申请日：2006-03-16
申请人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： C07D403/04 , C07D403/14 , A61K31/551 , A61P3/04
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译： 式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1， 具有权利要求1给出的意义的化合物可以以用于治疗或预防关节炎，心血管疾病，糖尿病，肾功能衰竭，饮食失调的药物制剂的形式使用， 肥胖。
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公开(公告)号：US07064134B2
公开(公告)日：2006-06-20
申请号：US11272207
申请日：2005-11-10
申请人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael G. Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4709 , A61P3/04
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
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公开(公告)号：US20050049413A1
公开(公告)日：2005-03-03
申请号：US10852509
申请日：2004-05-24
IPC分类号： A61K31/365 , A61K31/4706 , A61K31/4709 , A61K31/5377 , A61K31/55 , A61P3/00 , A61P3/04 , A61P3/10 , A61P19/02 , C07B61/00 , C07D215/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D491/10 , C07D491/113 , C07D41/02 , C07D43/02
CPC分类号： C07D401/12 , C07D215/42 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12
摘要： Quinoline derivatives are useful as neuropeptide Y (NPY) receptor ligands and are particularly effective as neuropeptide Y (NPY) antagonists. These compounds are useful in pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders, or obesity.
摘要翻译： 喹啉衍生物可用作神经肽Y（NPY）受体配体，并且作为神经肽Y（NPY）拮抗剂是特别有效的。 这些化合物可用于治疗或预防关节炎，心血管疾病，糖尿病，肾衰竭，进食障碍或肥胖症的药物制剂。
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公开(公告)号：US06818767B2
公开(公告)日：2004-11-16
申请号：US10151505
申请日：2002-05-20
IPC分类号： C07D21542
CPC分类号： C07D401/12 , C07D215/42 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12
摘要： Quinoline derivatives are useful as neuropeptide Y (NPY) receptor ligands and are particularly effective as neuropeptide Y (NPY) antagonists. These compounds are useful in pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders, or obesity.
摘要翻译： 喹啉衍生物可用作神经肽Y（NPY）受体配体，并且作为神经肽Y（NPY）拮抗剂是特别有效的。 这些化合物可用于治疗或预防关节炎，心血管疾病，糖尿病，肾衰竭，进食障碍或肥胖症的药物制剂。
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公开(公告)号：US06696467B2
公开(公告)日：2004-02-24
申请号：US10358006
申请日：2003-02-04
申请人： Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger
发明人： Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger
IPC分类号： A61K3146
CPC分类号： C07D401/04 , C07D215/42 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12
摘要： Compounds of general formula I as well as pharmaceutically acceptable salts and esters thereof, are potent inhibitors of neuropeptide Y and can be used in the form of pharmaceutical preparations for the treatment or prevention of various disease states and related morbidities including obesity.
摘要翻译： 通式I的化合物以及其药学上可接受的盐和酯是神经肽Y的有效抑制剂，并且可以药物制剂的形式用于治疗或预防各种疾病状态和相关疾病，包括肥胖症。
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公开(公告)号：US07205309B2
公开(公告)日：2007-04-17
申请号：US10613782
申请日：2003-07-03
申请人： Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger
发明人： Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Heinrich Nettekoven , Philippe Pflieger
IPC分类号： A61K31/55 , A61K31/54 , A61K31/517 , C07D239/72 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/12 , C07D239/94 , C07D239/95 , C07D401/14 , C07D403/04 , C07D405/12
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The compounds can be used for the treatment or prevention of obesity.
摘要翻译： 式I化合物
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