公开(公告)号：US07358094B2

公开(公告)日：2008-04-15

申请号：US10427404

申请日：2003-05-01

申请人： Michael L. Bell ,  Tony D. James ,  Susumu Arimori

发明人： Michael L. Bell ,  Tony D. James ,  Susumu Arimori

IPC分类号： G01N21/76 ,  C12Q1/68 ,  G01N33/00

CPC分类号： G01N33/54346 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/66 ,  Y10T436/143333

摘要： An analytical system for detecting a saccharide is provided. The analytical system includes a saccharide sensor attached to a solid substrate and having the formula: Where Z is selected from the group consisting of hydrogen, alkyl groups, an aryl; N is a nitrogen atom; Bd1 and Bd2 are independently selected binding groups, wherein the binding groups are capable of binding an saccharide; Sp is a spacer; An is an anchor group for attaching the sensor to solid substrate, including a bead; and n=1 or 2, m=1 or 2, y=1 or 2, and p is an integer. In one embodiment the saccharide sensor preferentially detects glucose. The invention further provides beads having the saccharide sensor attached thereto and methods of detecting glucose using the system.

摘要翻译： 提供了一种用于检测糖的分析系统。 分析系统包括连接到固体基质上的具有下式的糖传感器：其中Z选自氢，烷基，芳基; N是氮原子; B d1和B d2独立地选择结合基团，其中结合基团能够结合糖; Sp是间隔物 An是用于将传感器附接到固体基底的锚固组，包括珠; n = 1或2，m = 1或2，y = 1或2，p为整数。 在一个实施方案中，糖传感器优先检测葡萄糖。 本发明还提供了附着有糖传感器的珠粒和使用该系统检测葡萄糖的方法。

公开(公告)号：US06664407B2

公开(公告)日：2003-12-16

申请号：US10060790

申请日：2002-01-30

申请人： Tony D. James ,  Susumu Arimori

发明人： Tony D. James ,  Susumu Arimori

IPC分类号： C07F1702

CPC分类号： C12Q1/54 ,  C07F17/02

摘要： The invention provides compounds for detecting sacchharides by electrochemistry. The compounds have a structure that includes a first boronic acid group attached by a first linker group to a first tertiary amine. The first tertiary amine is attached to a reporter group that includes an organometalic reporter moiety. A spacer group attaches the first tertiary amine to a second tertiary amine. The second tertiary amine is attached to an R group and a second linker group. The second linker group is attached to a second boronic acid group. In preferred embodiments, the compound selectively detects glucose and has a higher relative stability constant for glucose than for other saccharides.

公开(公告)号：US06740257B2

公开(公告)日：2004-05-25

申请号：US10053274

申请日：2002-01-17

申请人： Susumu Arimori ,  Tony D. James

发明人： Susumu Arimori ,  Tony D. James

IPC分类号： C09K1106

CPC分类号： G01N33/533 ,  Y10T436/143333

摘要： Disclosed is a modular fluorescence sensor having the following general formula: Where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.

摘要翻译： 公开了具有以下通式的模块化荧光传感器：其中，F1是荧光团，N是氮原子，Bd1和Bd2是独立选择的结合基团，Sp是脂肪族间隔基，An是用于将传感器附着到 固体基材。 n = 1或2，m = 1或2，x为整数，y = 1或2.结合基团能够结合分析物分子以形成稳定的1:1复合物。 在优选的实施方式中，Bd1为R1-B（OH）2，Bd2为R2-B（OH）2。 R1和R2是彼此独立地选择的脂族或芳族官能团，B是硼原子。 本发明还提供了合成模块荧光传感器的方法及其在固体基质标记中的应用。

公开(公告)号：US06387672B1

公开(公告)日：2002-05-14

申请号：US09729332

申请日：2000-12-04

申请人： Susumu Arimori ,  Tony D. James

发明人： Susumu Arimori ,  Tony D. James

IPC分类号： C12N900

CPC分类号： G01N33/533 ,  Y10T436/143333

摘要： Disclosed is a modular fluorescence sensor having the following general formula: where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.

摘要翻译： 公开了具有以下通式的模块化荧光传感器：其中F1是荧光团，N是氮原子，Bd1和Bd2是独立选择的结合基团，Sp是脂肪族间隔基，An是用于将传感器附着到 固体基材。 n = 1或2，m = 1或2，x为整数，y = 1或2.结合基团能够结合分析物分子以形成稳定的1:1复合物。 在优选的实施方式中，Bd1为R1-B（OH）2，Bd2为R2-B（OH）2。 R1和R2是彼此独立地选择的脂族或芳族官能团，B是硼原子。 本发明还提供了合成模块荧光传感器的方法及其在固体基质标记中的应用。

公开(公告)号：US5783570A

公开(公告)日：1998-07-21

申请号：US774288

申请日：1996-12-23

申请人： Hideyuki Yokota ,  Masakazu Tanaka ,  Masahiro Seko ,  Noriko Monden ,  Susumu Arimori ,  Shigeji Konagaya

发明人： Hideyuki Yokota ,  Masakazu Tanaka ,  Masahiro Seko ,  Noriko Monden ,  Susumu Arimori ,  Shigeji Konagaya

IPC分类号： A61L31/16 ,  A61L33/00 ,  A61L33/08 ,  C08B37/00 ,  C08L101/00 ,  A61K31/70 ,  C08B37/10

CPC分类号： C08B37/0063 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  C08L101/00 ,  A61L2300/104 ,  A61L2300/236 ,  A61L2300/404 ,  A61L2300/42 ,  A61L2300/45 ,  C08L2203/02

摘要： The present invention relates to an organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide (preferably heparin or heparin derivative) and a quaternary phosphonium, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an organic polymer material, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an antibacterial agent (preferably inorganic antibacterial agent such as silver zeolite), and to a medical material comprising said organic solvent-soluble mucopolysaccharide. The organic solvent-soluble mucopolysaccharide, and the antibacterial antithrombogenic composition and medical material containing the same, of the present invention, can easily impart antithrombogenicity and antibacterial property to a polymer to be a base material, which properties being maintained not only immediately after preparation of the material but also after long-term elution. Thus, the organic solvent-soluble mucopolysaccharide and antibacterial antithrombogenic material of the present invention show superior applicability as a material to impart antithrombogenicity and antibacterial ability to medical materials.

摘要翻译： 本发明涉及由至少一种粘多糖（优选肝素或肝素衍生物）和季鏻的离子络合物，包含所述有机溶剂可溶性粘多糖和有机聚合物材料的抗菌抗血栓形成组合物组成的有机溶剂可溶性粘多糖， 包含所述有机溶剂可溶性粘多糖和抗菌剂（优选无机抗菌剂如银沸石）的抗菌抗血栓形成组合物和包含所述有机溶剂可溶性粘多糖的医疗材料。 本发明的有机溶剂可溶性粘多糖，抗菌抗血栓形成组合物和含有该抗菌素的药物组合物及其医疗材料能够容易地将聚合物的抗凝血性和抗菌性赋予基材，这些性质不仅在制备 该物质也经过长时间洗脱。 因此，本发明的有机溶剂可溶性粘多糖和抗菌抗血栓形成材料作为赋予医疗材料抗凝血性和抗菌能力的材料具有优异的适用性。

公开(公告)号：US6040415A

公开(公告)日：2000-03-21

申请号：US147392

申请日：1998-12-15

申请人： Susumu Arimori ,  Masahiro Seko ,  Masakazu Tanaka ,  Noriko Monden ,  Hideyuki Yokota

发明人： Susumu Arimori ,  Masahiro Seko ,  Masakazu Tanaka ,  Noriko Monden ,  Hideyuki Yokota

IPC分类号： A61L33/06 ,  C08G18/38 ,  C08G18/32 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80

CPC分类号： C08G18/3889 ,  A61L33/068

摘要： Tpresent invention provide a biocompatible polyurethane or oplyurethane urea containing, in the side chain, phosphorylcholine structure represented by the formula (1) ##STR1## wherein R.sup.1 is C.sub.1-20 alkyl, C.sub.6-12 aryl, C.sub.7-20 aralkyl or a group of the formula:R.sup.4 -(A).sub.n -(wherein A is C.sub.2-10 oxyalkylene, and (A).sub.n may be constituted of one kind of oxyalkylene groups or of two or more kinds of oxyalkylene groups linked together in blocks or at random; n is an integer of 1 to 30; and R.sup.4 is C.sub.1-20 alkyl, C.sub.6-12 aryl or C.sub.7-20 aralkyl); and R.sup.2 and R.sup.3 each represent C.sub.1-20 alkyl, C.sub.6-12 aryl or C.sub.7-20 aralkyl and may be the same or different; and an antithrombogenic medical product prepared using the polyurethane or polyurethane urea.

摘要翻译： PCT No.PCT / JP98 / 01702 Sec。 371 1998年12月15日第 102（e）1998年12月15日日期PCT提交1998年4月13日PCT公布。 公开号WO98 / 46659 日本特开1998年10月22日本发明提供一种生物相容性聚氨酯或聚氨酯脲，其在侧链中含有式（1）所示的磷酸胆碱结构，其中R1为C1-20烷基，C6-12芳基，C7-20芳烷基或基团 （A）n-（其中A是C2-10氧化烯，和（A）n可以由一种氧化烯基团或两种或多种氧化烯基团在块中或随机连接而构成 ; n为1〜30的整数，R4为C1-20烷基，C6-12芳基或C7-20芳烷基）; 并且R 2和R 3各自表示C 1-20烷基，C 6-12芳基或C 7-20芳烷基，并且可以相同或不同; 和使用聚氨酯或聚氨酯脲制备的抗血栓形成的医药产品。

公开(公告)号：US06191192B1

公开(公告)日：2001-02-20

申请号：US09100250

申请日：1998-06-19

申请人： Noriko Monden ,  Masahiro Seko ,  Hideyuki Yokota ,  Masakazu Tanaka ,  Susumu Arimori

发明人： Noriko Monden ,  Masahiro Seko ,  Hideyuki Yokota ,  Masakazu Tanaka ,  Susumu Arimori

IPC分类号： A61M2500

CPC分类号： C08K5/0058 ,  A01N25/34 ,  A01N59/16 ,  A61B42/00 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/208 ,  A61L2300/216 ,  A61L2300/404 ,  C08J5/02 ,  C08J7/065 ,  A01N2300/00

摘要： The invention provides an antibacterial polymeric molded product containing an anionic compound capable of combining, by ionic bond, with a cationic component of a water-soluble antibacterial agent, wherein the cationic component is combined with the anionic compound by ionic bond at least at the surface of the molded product.

摘要翻译： 本发明提供了一种抗菌聚合物模制产品，其含有能够通过离子键与水溶性抗菌剂的阳离子组分结合的阴离子化合物，其中阳离子组分至少在表面上通过离子键与阴离子化合物结合 的成型产品。