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公开(公告)号：US20160376361A1
公开(公告)日：2016-12-29
申请号：US15164508
申请日：2016-05-25
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号：US10081677B2
公开(公告)日：2018-09-25
申请号：US15164508
申请日：2016-05-25
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
摘要： Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
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公开(公告)号：US20140112915A1
公开(公告)日：2014-04-24
申请号：US14017561
申请日：2013-09-04
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号：US09376489B2
公开(公告)日：2016-06-28
申请号：US14017561
申请日：2013-09-04
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： 白介素18（IL-18）参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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