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公开(公告)号：US20140112915A1
公开(公告)日：2014-04-24
申请号：US14017561
申请日：2013-09-04
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号：US09376489B2
公开(公告)日：2016-06-28
申请号：US14017561
申请日：2013-09-04
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： 白介素18（IL-18）参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号：US20160376361A1
公开(公告)日：2016-12-29
申请号：US15164508
申请日：2016-05-25
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号： C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要： IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译： IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白（IL18BP）（天然存在和高度特异性抑制剂）的负调控。 该可溶性蛋白质与游离IL-18形成复合物，防止其与IL-18受体的相互作用，从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP（IL-18 / IL-18BP复合物）的IL-18的结合分子，特别是抗体或其片段。 除了其生理作用外，IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子，或作为用于表征，检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号：US10081677B2
公开(公告)日：2018-09-25
申请号：US15164508
申请日：2016-05-25
申请人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人： Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silverster Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
摘要： Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
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5.发明授权公开(公告)号：US08883158B2
公开(公告)日：2014-11-11
申请号：US13557562
申请日：2012-07-25
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
IPC分类号： A61K39/395 , C07K16/18 , C07K16/46
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译： 本发明涉及靶向补体蛋白C5的抗体及其使用方法。
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6.发明授权公开(公告)号：US08241628B2
公开(公告)日：2012-08-14
申请号：US12535205
申请日：2009-08-04
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/16
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译： 本发明涉及靶向补体蛋白C5的抗体及其使用方法。
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7.发明申请公开(公告)号：US20100034809A1
公开(公告)日：2010-02-11
申请号：US12535205
申请日：2009-08-04
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译： 本发明涉及靶向补体蛋白C5的抗体及其使用方法。
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公开(公告)号：US20090130113A1
公开(公告)日：2009-05-21
申请号：US12249050
申请日：2008-10-10
申请人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
发明人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/63 , C12N5/00 , C12P21/00 , G01N33/53 , A61K31/675 , A61K31/663 , A61P19/08
CPC分类号： G01N33/6854 , A61K31/663 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N2333/51 , G01N2800/108 , A61K2300/00
摘要： The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.
摘要翻译： 本发明涉及抗硬化蛋白的抗体及其用于治疗与骨异常如骨质疏松有关的疾病的所述抗体的组合物和方法。 本发明的一个实施方案提供了一种抗体或功能性蛋白质，其包含所述抗体在硬化蛋白多肽中的靶标的抗原结合部分，其特征在于所述抗体或功能性蛋白质特异性结合硬化蛋白多肽，并可增加至少一种骨 形成，骨矿物质密度，骨矿物质含量，骨质量，骨质量和骨强度。
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公开(公告)号：US20110052592A1
公开(公告)日：2011-03-03
申请号：US12944019
申请日：2010-11-11
申请人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
发明人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
CPC分类号： G01N33/6854 , A61K31/663 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N2333/51 , G01N2800/108 , A61K2300/00
摘要： The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease related to bone abnormalities such as osteoporosis.
摘要翻译： 本发明涉及抗硬化蛋白的抗体以及用于所述抗体治疗由硬化症介入的病理学疾病或与骨质异常如骨质疏松有关的疾病的组合物和方法。
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公开(公告)号：US07879322B2
公开(公告)日：2011-02-01
申请号：US12249050
申请日：2008-10-10
申请人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
发明人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/26 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/6854 , A61K31/663 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N2333/51 , G01N2800/108 , A61K2300/00
摘要： The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.
摘要翻译： 本发明涉及抗硬化蛋白的抗体及其用于治疗与骨异常如骨质疏松有关的疾病的所述抗体的组合物和方法。 本发明的一个实施方案提供了一种抗体或功能性蛋白质，其包含所述抗体在硬化蛋白多肽中的靶标的抗原结合部分，其特征在于所述抗体或功能性蛋白质特异性结合硬化蛋白多肽，并可增加至少一种骨 形成，骨矿物质密度，骨矿物质含量，骨质量，骨质量和骨强度。
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