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公开(公告)号:US09376489B2
公开(公告)日:2016-06-28
申请号:US14017561
申请日:2013-09-04
申请人: Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人: Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号: C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要: Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译: 白介素18(IL-18)参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白(IL18BP)(天然存在和高度特异性抑制剂)的负调控。 该可溶性蛋白质与游离IL-18形成复合物,防止其与IL-18受体的相互作用,从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP(IL-18 / IL-18BP复合物)的IL-18的结合分子,特别是抗体或其片段。 除了其生理作用外,IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子,或作为用于表征,检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号:US20150158936A1
公开(公告)日:2015-06-11
申请号:US14309330
申请日:2014-06-19
申请人: Leslie Ngozi Anuna Johnson , Ute Jaeger , Yong-In Kim , Christian Carsten Silvester KUNZ , Igor Splawski , Michael Roguska , Joy Ghosh , Barbara Brannetti , Michael Stefanidakis , Sha-Mei Liao
发明人: Leslie Ngozi Anuna Johnson , Ute Jaeger , Yong-In Kim , Christian Carsten Silvester KUNZ , Igor Splawski , Michael Roguska , Joy Ghosh , Barbara Brannetti , Michael Stefanidakis , Sha-Mei Liao
IPC分类号: C07K16/18
CPC分类号: C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6863
摘要: The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
摘要翻译: 本发明涉及结合补体因子P并用于其的抗体或其抗原结合片段,以及抗因子P抗体与结合补体成分5(C5)的抗体或其抗原结合片段的组合。
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公开(公告)号:US20140112915A1
公开(公告)日:2014-04-24
申请号:US14017561
申请日:2013-09-04
申请人: Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
发明人: Michael Otto Bardroff , Barbara Brannetti , Emma Michelle Campbell , Beate Diefenbach-Streiber , Adina Eberth , Christian Carsten Silvester Kunz , Sylwia Marshall , Jean-Michel Rene Rondeau , Jean-Marc Alfred Schlaeppi , Gino Anselmus Van Heeke
CPC分类号: C07K16/244 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/6854 , G01N2333/54
摘要: IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
摘要翻译: IL-18参与了先天免疫和获得性免疫。 IL-18的生物活性受到IL-18结合蛋白(IL18BP)(天然存在和高度特异性抑制剂)的负调控。 该可溶性蛋白质与游离IL-18形成复合物,防止其与IL-18受体的相互作用,从而中和并抑制其生物学活性。 本发明公开了结合IL-18并且不结合IL-18BP(IL-18 / IL-18BP复合物)的IL-18的结合分子,特别是抗体或其片段。 除了其生理作用外,IL-18已被证明可以介导各种自身免疫性疾病和炎性疾病。 本发明的结合分子可用作治疗IL-18相关的自身免疫性和炎症性疾病的治疗分子,或作为用于表征,检测和/或测定IL-18BP不结合IL-18BP作为总IL的组分的诊断工具 -18游泳池。
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公开(公告)号:US20120107306A1
公开(公告)日:2012-05-03
申请号:US13214413
申请日:2011-08-22
申请人: Winfried ELIS , Seth ETTENGERG , Andrew Paul GARNER , Nicole HAUBST , Christian Carsten Silvester KUNZ , Elizabeth Anne Reisinger SPRAGUE
发明人: Winfried ELIS , Seth ETTENGERG , Andrew Paul GARNER , Nicole HAUBST , Christian Carsten Silvester KUNZ , Elizabeth Anne Reisinger SPRAGUE
IPC分类号: A61K39/395 , A61P35/00 , A61P35/02 , C07K16/40
CPC分类号: C07K16/32 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.
摘要翻译: 本发明涉及靶向HER受体的构象表位的抗体或其片段。 特别地,本发明涉及靶向HER3受体的构象表位的抗体或其片段,以及组合物及其使用方法。
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