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公开(公告)号：US08278325B2
公开(公告)日：2012-10-02
申请号：US13186351
申请日：2011-07-19
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/26 , A61K31/472
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US07323475B2
公开(公告)日：2008-01-29
申请号：US10861082
申请日：2004-06-04
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/12 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US07863292B2
公开(公告)日：2011-01-04
申请号：US11624949
申请日：2007-01-19
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D403/02 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US08916585B2
公开(公告)日：2014-12-23
申请号：US13599161
申请日：2012-08-30
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： C07D217/24 , A61K31/472 , A61K38/18 , C07D217/26 , C07D401/04 , C07D401/06 , C07D221/08 , C07D401/12 , C07D403/12
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
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公开(公告)号：US20130310565A1
公开(公告)日：2013-11-21
申请号：US13912483
申请日：2013-06-07
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： C07D217/26
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
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6.发明申请公开(公告)号：US20120029011A1
公开(公告)日：2012-02-02
申请号：US13186351
申请日：2011-07-19
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： A61K31/472 , C07D401/04 , A61P7/00 , A61K31/4725 , A61P7/06 , A61P9/10 , C07D217/26 , C07D401/12
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US08017625B2
公开(公告)日：2011-09-13
申请号：US12015275
申请日：2008-01-16
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/12 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
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公开(公告)号：US07629357B2
公开(公告)日：2009-12-08
申请号：US11442727
申请日：2006-05-26
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/02 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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9.发明申请公开(公告)号：US20080293763A1
公开(公告)日：2008-11-27
申请号：US12015275
申请日：2008-01-16
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： A61K31/472 , C12N9/99
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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10.发明申请公开(公告)号：US20070185159A1
公开(公告)日：2007-08-09
申请号：US11624949
申请日：2007-01-19
申请人： Michael AREND , Lee Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael AREND , Lee Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： A61K31/4709 , C07D403/02
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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