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公开(公告)号：US20110039878A1
公开(公告)日：2011-02-17
申请号：US12734444
申请日：2008-11-03
IPC分类号： A61K31/437 , A61K31/47 , A61P9/12
CPC分类号： C07D471/04 , A61K31/437 , A61K31/472 , C07D217/26
摘要： The present invention provides methods and medicaments for reducing blood pressure. Methods and medicaments for treating or preventing hypertension are also provided.
摘要翻译： 本发明提供用于降低血压的方法和药物。 还提供了治疗或预防高血压的方法和药物。
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公开(公告)号：US20060258702A1
公开(公告)日：2006-11-16
申请号：US11495118
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/47
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：US20050020487A1
公开(公告)日：2005-01-27
申请号：US10861590
申请日：2004-06-03
申请人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
发明人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
IPC分类号： A61K31/00 , A61K31/165 , A61K31/395 , A61P7/06 , A61K38/16
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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4.发明申请METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE 审中-公开使用HYPOXIA诱导因子（HIF）羟化酶抑制剂治疗KIDNEY失败的受试者中的ANEMIA的方法公开(公告)号：US20150080425A1
公开(公告)日：2015-03-19
申请号：US14332814
申请日：2014-07-16
申请人： STEPHEN J. KLAUS , Al Y. Lin , Thomas B. Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Lee A. Flippin , Michael P. Arend , Alex Melekhov
发明人： STEPHEN J. KLAUS , Al Y. Lin , Thomas B. Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Lee A. Flippin , Michael P. Arend , Alex Melekhov
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase.
摘要翻译： 本发明提供了通过施用抑制缺氧诱导因子（HIF）脯氨酰羟化酶的化合物来治疗患有肾衰竭的受试者的贫血的方法。
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公开(公告)号：US08604013B2
公开(公告)日：2013-12-10
申请号：US12804042
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods for treating anemia in a subject having a low percent transferrin saturation by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
摘要翻译： 本发明涉及通过向受试者施用有效量的抑制缺氧诱导因子脯氨酰羟化酶活性的化合物来治疗具有低转铁蛋白饱和度的受试者的贫血的方法。
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公开(公告)号：US20130245037A1
公开(公告)日：2013-09-19
申请号：US13897207
申请日：2013-05-17
申请人： Volkmar Guenzler-Pukall , Thomas B. Neff , Qingjian Wang , Michael P. Arend , Lee A. Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas B. Neff , Qingjian Wang , Michael P. Arend , Lee A. Flippin , Alex Melekhov
IPC分类号： A61K31/496 , A61K31/472 , A61K31/4418 , A61K31/47 , A61K31/44 , A61K31/4375 , A61K31/17
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
摘要翻译： 本发明涉及稳定缺氧诱导因子（HIF）的α亚基的方法。 本发明还涉及预防，预处理或治疗与HIF相关的病症（包括缺血和缺氧病症）的方法。 还提供了用于这些方法的化合物。
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公开(公告)号：US08278325B2
公开(公告)日：2012-10-02
申请号：US13186351
申请日：2011-07-19
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/26 , A61K31/472
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US20110038950A1
公开(公告)日：2011-02-17
申请号：US12804042
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC分类号： A61K31/33 , A61K33/26 , A61K31/51 , A61K31/525 , A61K31/714 , A61K31/4415 , A61P7/06
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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公开(公告)号：US20100280044A1
公开(公告)日：2010-11-04
申请号：US12804029
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC分类号： A61K31/496 , A61K31/44 , A61K31/472 , A61P7/06 , A61P7/00
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
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10.发明申请公开(公告)号：US20080293763A1
公开(公告)日：2008-11-27
申请号：US12015275
申请日：2008-01-16
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： A61K31/472 , C12N9/99
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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