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公开(公告)号：US07928120B2
公开(公告)日：2011-04-19
申请号：US11627906
申请日：2007-01-26
申请人： Michael Arend , Lee A. Flippin , Min Wu , Eric D. Turtle , Wen-Bin Ho , Shaojiang Deng
发明人： Michael Arend , Lee A. Flippin , Min Wu , Eric D. Turtle , Wen-Bin Ho , Shaojiang Deng
IPC分类号： A01N43/42 , A01N43/40 , A61K31/47 , A61K31/435 , A61K31/44
CPC分类号： C07D217/26 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:
摘要翻译： 本发明涉及适合用于治疗缺氧诱导因子介导和/或促红细胞生成素相关病症的氰基异喹啉化合物。 本发明的氰基异喹啉化合物具有以下结构：
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公开(公告)号：US20060199836A1
公开(公告)日：2006-09-07
申请号：US11367969
申请日：2006-03-02
申请人： Eric Turtle , Lee Flippin , Michael Arend , Heng Cheng
发明人： Eric Turtle , Lee Flippin , Michael Arend , Heng Cheng
IPC分类号： A61K31/4743 , C07D498/02
CPC分类号： C07D495/04 , C07D498/02
摘要： The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
摘要翻译： 本发明涉及能够调节缺氧诱导因子（HIF）的稳定性和/或活性的新型化合物。
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3.发明申请公开(公告)号：US20080004309A1
公开(公告)日：2008-01-03
申请号：US11696549
申请日：2007-04-04
申请人： Shaojiang DENG , Min Wu , Eric Turtle , Wen-Bin Ho , Michael Arend , Heng Cheng , Lee Flippin
发明人： Shaojiang DENG , Min Wu , Eric Turtle , Wen-Bin Ho , Michael Arend , Heng Cheng , Lee Flippin
IPC分类号： A61K31/435 , A61P9/00 , C07D471/02
CPC分类号： C07D471/04 , C07D513/04
摘要： The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
摘要翻译： 本发明涉及能够调节缺氧诱导因子（HIF）的稳定性和/或活性的新型化合物。
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公开(公告)号：US20060270699A1
公开(公告)日：2006-11-30
申请号：US11494978
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：US20060178316A1
公开(公告)日：2006-08-10
申请号：US11406023
申请日：2006-04-17
申请人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
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公开(公告)号：US20060258660A1
公开(公告)日：2006-11-16
申请号：US11495036
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/502
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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7.发明申请公开(公告)号：US20060217416A1
公开(公告)日：2006-09-28
申请号：US11442727
申请日：2006-05-26
申请人： Michael Arend , Lee Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael Arend , Lee Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/02 , A61K31/4709 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译： 本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。
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公开(公告)号：US20060178317A1
公开(公告)日：2006-08-10
申请号：US11406484
申请日：2006-04-17
申请人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K38/04 , A61K31/4745
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
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公开(公告)号：US20070298104A1
公开(公告)日：2007-12-27
申请号：US11627906
申请日：2007-01-26
申请人： Michael Arend , Lee Flippin , Min Wu , Eric Turtle , Wen-Bin Ho , Shaojiang Deng
发明人： Michael Arend , Lee Flippin , Min Wu , Eric Turtle , Wen-Bin Ho , Shaojiang Deng
IPC分类号： A61K31/47 , A61K31/714 , A61K33/26 , A61K38/16 , A61K38/22 , A61P1/00 , A61P43/00 , A61P9/00 , C07D217/00 , C12N9/99
CPC分类号： C07D217/26 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure:
摘要翻译： 本发明涉及适合用于治疗缺氧诱导因子介导和/或促红细胞生成素相关病症的氰基异喹啉化合物。 本发明的氰基异喹啉化合物具有以下结构：
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公开(公告)号：US20060258702A1
公开(公告)日：2006-11-16
申请号：US11495118
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/47
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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