公开(公告)号：US20060159707A1

公开(公告)日：2006-07-20

申请号：US11386138

申请日：2006-03-21

申请人： Michael Panaccio ,  Everett Rosey ,  Meri Sinistaj ,  Detlef Hasse ,  Jim Parsons ,  Robert Ankenbauer

发明人： Michael Panaccio ,  Everett Rosey ,  Meri Sinistaj ,  Detlef Hasse ,  Jim Parsons ,  Robert Ankenbauer

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12P21/06 ,  C07K14/195 ,  C12N1/21 ,  C12N15/74

CPC分类号： C07K14/195 ,  A61K39/00 ,  C07K14/205 ,  C12Q1/689

摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic FlgE peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

摘要翻译： 本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。 特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性FlgE肽，多肽或蛋白质，其特别可用作疫苗制剂中的抗原，以赋予动物宿主中针对胞内劳森氏菌和相关病原体的体液免疫。 本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。

公开(公告)号：US07052697B1

公开(公告)日：2006-05-30

申请号：US10018290

申请日：2000-05-11

申请人： Detlef Hasse ,  Michael Panaccio ,  Meri Sinistaj

发明人： Detlef Hasse ,  Michael Panaccio ,  Meri Sinistaj

IPC分类号： A61K39/02 ,  A61K39/00 ,  C07K14/195

CPC分类号： C07K14/205

摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic OmpH peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

公开(公告)号：US20060018920A1

公开(公告)日：2006-01-26

申请号：US11215658

申请日：2005-08-30

申请人： Detlef Hasse ,  Michael Panaccio ,  Meri Sinistaj

发明人： Detlef Hasse ,  Michael Panaccio ,  Meri Sinistaj

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C07K14/195

CPC分类号： C07K14/205 ,  A61K39/00 ,  A61K2039/53

摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic OmpH peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

摘要翻译： 本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。 特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性OmpH肽，多肽或蛋白质，其特别可用作疫苗制剂中的抗原，用于赋予动物宿主中针对胞内劳森氏菌和相关病原体的体液免疫。 本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。