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公开(公告)号：US06787135B2
公开(公告)日：2004-09-07
申请号：US10096568
申请日：2002-03-13
IPC分类号： A61K3848
CPC分类号： A61K38/484
摘要： Methods of modifying total MMP activity levels in the vitreous of an eye are provided. In a preferred embodiment, the method results in reduced MMP activity and comprises introducing plasmin into the vitreous of the eye. Enzyme assisted vitrectomy procedures are also provided, and comprise introducing plasmin into the vitreous in an amount sufficient to induce posterior detachment of the vitreous, mechanically detaching the vitreous from the eye, introducing a replacement fluid into the eye, and introducing plasmin into the eye in an amount sufficient to decrease the total MMP activity in vitreous. Considering the purported roles of MMPs in a variety of vitreal pathologies, the present invention provides methods of inhibiting the progression of various disease conditions, including prolifertaive diabetic retinopathy.
摘要翻译： 提供了改善眼睛玻璃体总MMP活性水平的方法。 在优选的实施方案中，该方法导致MMP活性降低，并且包括将纤溶酶导入眼睛的玻璃体。 还提供了酶辅助的玻璃体切除术，并且包括将纤维蛋白溶胶引入玻璃体中，其量足以引起玻璃体的后脱离，机械地将玻璃体从眼睛中分离出来，将更换的流体引入眼中，并将纤溶酶引入眼中 足以降低玻璃体中总MMP活性的量。 考虑到MMP在各种玻璃体病变中的作用，本发明提供了抑制各种疾病状况（包括增生性糖尿病性视网膜病变）进展的方法。
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公开(公告)号：US06207066B1
公开(公告)日：2001-03-27
申请号：US09178970
申请日：1998-10-26
IPC分类号： B01D1508
CPC分类号： C12N9/6435 , A61K38/00 , B01D15/34 , B01D15/361 , B01D15/3804 , B01J20/3204 , B01J20/3219 , B01J20/3274 , C12Y304/21007 , G01N30/6091 , Y10T436/25375 , Y10T436/255
摘要： A method for rapid purification of a blood component from blood is described in which the blood plasma is first separated from the cellular blood elements by any conventional means, such as centrifugation. An affinity cartridge is then activated with a molecule, such as an amino acid, which binds with a blood component such as plasminogen. The separated blood plasma is then passed through the affinity cartridge such that the blood component is retained by the affinity cartridge. Thereafter, the blood component is eluted from the affinity cartridge by passing a buffer solution containing a releasing agent through the affinity cartridge. This releasing agent disengages the blood component from the affinity cartridge. The releasing agent is then separated from the eluted solution by passing the eluted solution through a device, such as an ion exchange or size exclusion device. The separated blood component, e.g. plasminogen, is then converted to plasmin by adding a known amount of an enzyme to the solution from which the releasing agent has been removed.
摘要翻译： 描述了从血液中快速纯化血液成分的方法，其中血浆首先通过任何常规方法如离心分离于细胞血液元件。 然后用与诸如纤溶酶原的血液成分结合的分子（例如氨基酸）活化亲和柱。 然后将分离的血浆通过亲和柱，使得血液成分被亲和柱保持。 此后，通过使含有脱模剂的缓冲溶液通过亲和柱，从亲和柱洗脱血液成分。 该释放剂使血液成分从亲和药筒脱离。 然后通过使洗脱的溶液通过诸如离子交换或尺寸排阻装置的装置将脱模剂与洗脱的溶液分离。 分离的血液成分，例如 然后通过向去除了脱模剂的溶液中加入已知量的酶将其转化为纤溶酶。
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公开(公告)号：US06183692B2
公开(公告)日：2001-02-06
申请号：US09505272
申请日：2000-02-16
IPC分类号： A61K3514
CPC分类号： C12N9/6435 , A61K38/00 , B01D15/34 , B01D15/361 , B01D15/3804 , B01J20/3204 , B01J20/3219 , B01J20/3274 , C12Y304/21007 , G01N30/6091 , Y10T436/25375 , Y10T436/255
摘要： A method for rapid purification of a blood component from blood is described in which the blood plasma is first separated from the cellular blood elements by any conventional means, such as centrifugation. An affinity cartridge is then activated with a molecule, such as an amino acid, which binds with a blood component such as plasminogen. The separated blood plasma is then passed through the affinity cartridge such that the blood component is retained by the affinity cartridge. Thereafter, the blood component is eluted from the affinity cartridge by passing a buffer solution containing a releasing agent through the affinity cartridge. This releasing agent disengages the blood component from the affinity cartridge. The releasing agent is then separated from the eluted solution by passing the eluted solution through a device, such as an ion exchange or size exclusion device. The separated blood component, e.g. plasminogen, is then converted to plasmin by adding a known amount of an enzyme to the solution from which the releasing agent has been removed.
摘要翻译： 描述了从血液中快速纯化血液成分的方法，其中血浆首先通过任何常规方法如离心分离于细胞血液元件。 然后用与诸如纤溶酶原的血液成分结合的分子（例如氨基酸）活化亲和柱。 然后将分离的血浆通过亲和柱，使得血液成分被亲和柱保持。 此后，通过使含有脱模剂的缓冲溶液通过亲和柱，从亲和柱洗脱血液成分。 该释放剂使血液成分从亲和药筒脱离。 然后通过使洗脱的溶液通过诸如离子交换或尺寸排阻装置的装置将脱模剂与洗脱的溶液分离。 分离的血液成分，例如 然后通过向去除了脱模剂的溶液中加入已知量的酶将其转化为纤溶酶。
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公开(公告)号：US5304118A
公开(公告)日：1994-04-19
申请号：US991253
申请日：1992-12-16
CPC分类号： A61F9/00736
摘要： A method for performing a vitrectomy on an eye is disclosed for removing the vitreous humor from the eye. The method comprises the first step of introducing plasmin into the vitreous humor in order to induce a posterior vitreous detachment. Thereafter, the vitreous is removed by conventional methods and replaced with a sterile saline solution.
摘要翻译： 公开了一种用于在眼睛上进行玻璃体切割术的方法，用于从眼睛中去除玻璃体液。 该方法包括将纤溶酶引入玻璃体液中以诱导玻璃体后脱离的第一步骤。 此后，通过常规方法除去玻璃体，并用无菌盐水溶液代替。
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公开(公告)号：US07776026B2
公开(公告)日：2010-08-17
申请号：US10068314
申请日：2002-02-06
CPC分类号： A61K38/484
摘要： A process is disclosed for liquefying the vitreous humor of an eye. The process includes the steps of delivering plasmin into the vitreous of the eye and incubating the vitreous and plasmin together for a period of time. Plasmin may be introduced through injection or a sustained release device. Plasmin may be used to treat a pathological condition of the eye such as diabetic retinopathy, macular hole, macular pucker, intraocular infection, foreign intraocular material and retinal detachment.
摘要翻译： 公开了一种用于液化眼睛的玻璃体液的方法。 该方法包括以下步骤：将纤溶酶递送到眼玻璃体中并将玻璃体和纤溶酶一起孵育一段时间。 可以通过注射或持续释放装置引入纤溶酶。 纤溶酶可用于治疗眼睛的病理状况，例如糖尿病性视网膜病变，黄斑裂孔，黄斑褶皱，眼内感染，异物眼内物质和视网膜脱离。
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公开(公告)号：US06855263B2
公开(公告)日：2005-02-15
申请号：US10201125
申请日：2002-07-23
申请人： Michael T. Trese , George A. Williams , Michael K. Hartzer , Wendelin A. Dailey , Craig J. Bell
发明人： Michael T. Trese , George A. Williams , Michael K. Hartzer , Wendelin A. Dailey , Craig J. Bell
CPC分类号： C12N9/6435 , C12Y304/21007 , Y10T436/25375
摘要： A method for rapid purification of a blood component from blood is described in which the blood plasma is first separated from the cellular blood elements by any conventional means, such as centrifugation. An affinity cartridge is then activated with a molecule, such as an amino acid, which binds with a blood component such as plasminogen. The separated blood plasma is then passed through the affinity cartridge such that the blood component is retained by the affinity cartridge. Thereafter, the blood component is eluted from the affinity cartridge by passing a buffer solution containing a releasing agent through the affinity cartridge. This releasing agent disengages the blood component from the affinity cartridge. The releasing agent is then separated from the eluted solution by passing the eluted solution through a device, such as an ion exchange, gel filter, or size exclusion device. The isolated plasminogen solution is then concentrated by a factor of from 2 to 10. The separated blood component, e.g. plasminogen, is then converted to plasmin by adding a known amount of an enzyme to the solution from which the releasing agent has been removed.
摘要翻译： 描述了从血液中快速纯化血液成分的方法，其中血浆首先通过任何常规方法如离心分离于细胞血液元件。 然后用与诸如纤溶酶原的血液成分结合的分子（例如氨基酸）活化亲和柱。 然后将分离的血浆通过亲和柱，使得血液成分被亲和柱保持。 此后，通过使含有脱模剂的缓冲溶液通过亲和柱，从亲和柱洗脱血液成分。 该释放剂使血液成分从亲和药筒脱离。 然后通过使洗脱的溶液通过诸如离子交换，凝胶过滤器或尺寸排阻装置的装置将脱模剂与洗脱的溶液分离。 然后将分离的纤溶酶原溶液浓缩2至10倍。 然后通过向去除了脱模剂的溶液中加入已知量的酶将其转化为纤溶酶。
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公开(公告)号：US4638172A
公开(公告)日：1987-01-20
申请号：US675227
申请日：1984-11-27
申请人： George A. Williams
发明人： George A. Williams
CPC分类号： F02B75/34 , H02K7/1815 , F02B2075/025
摘要： The Engine-Generator combination comprises a small internal-combustion engine, such as is used to power model vehicles, such as model airplanes, and a direct-current generator operatively coupled to the engine. The generator produces from four volts and one hundred and fifty milliamperes of current to one hundred volts and a current in excess of two hundred and fifty milliamperes, upon the engine being run at speeds of from three thousand revolutions per minute to twenty thousand revolutions per minute, where the generator has from six hundred turns of #36 gauge magnetic wire on each of the three poles thereof, to one thousand turns of #40 gauge magnetic wire on each of the three poles. The generator, driven by the engine provides its direct-current power to charge nicade batteries carried by, and used by a model vehicle in which the engine-generator is installed.
摘要翻译： 发动机 - 发电机组合包括小型内燃机，例如用于对诸如模型飞机的模型车辆进行动力，以及可操作地联接到发动机的直流发电机。 当发动机以三千转/分钟的速度运行到每分钟二万转时，发电机产生四伏特和一百五十毫安电流到一百伏特的电流和超过二百五十毫安的电流 其中发电机在其三极中的每一个上具有六百匝的＃36规格的磁线，在三极中的每一个上都有一千匝的＃40规格的磁性线。 由发动机驱动的发电机提供其直流电力来对安装有发动机发电机的模型车辆携带并由其使用的小电池充电。
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公开(公告)号：USD409022S
公开(公告)日：1999-05-04
申请号：US79980
申请日：1997-11-25
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公开(公告)号：US4047014A
公开(公告)日：1977-09-06
申请号：US672893
申请日：1976-04-02
摘要： An electronically controlled coordinate converter for transforming vectors from a first coordinate system to a second coordinate system through an input angle is provided using a harmonic oscillator which is responsive to an oscillation angle control signal having a discontinuity or transition point wherein an incremental change in the input angle at a predetermined value causes a step function in the duration of said oscillation angle control signal. The discontinuity in the oscillation angle control signal is eliminated by control circuits within a selected range of input angles where the error effects due to transformations on either side of the discontinuity are avoided. Another feature of the invention is that the discontinuity in the oscillation angle control signal may be shifted away from or in response to a previous vector transformation having an input angle close to the discontinuity to avoid recurrent vector transformations on either side of the oscillation angle control signal discontinuity due to slight incremental fluctuations in the input angle.
摘要翻译： 使用谐波振荡器提供用于通过输入角将矢量从第一坐标系变换到第二坐标系的电子控制坐标转换器，其响应于具有不连续或转变点的振荡角控制信号，其中输入的增量变化 在预定值处的角度在所述振荡角度控制信号的持续时间内产生阶跃函数。 振荡角度控制信号中的不连续性由输入角度选定范围内的控制电路消除，其中避免了由于不连续性的任一侧上的变换导致的误差效应。 本发明的另一个特征是振荡角度控制信号的不连续性可以偏离或响应于具有接近于不连续性的输入角的先前矢量变换，以避免在振荡角度控制信号的任一侧上的反复向量变换 由于输入角度的轻微增量波动引起的不连续性。
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公开(公告)号：US11578294B2
公开(公告)日：2023-02-14
申请号：US13670584
申请日：2012-11-07
摘要： A method for preparing a neutral alcoholic malt base is disclosed. The method includes the steps of combining malt extract, which can be derived from malted grains containing gluten, or from those that are gluten-free, fermentable sugar in liquid or solid form, and water to form a fermentable medium having a density of greater than 20° Plato, wherein a ratio of the malt extract to the fermentable sugar in the fermentable medium is from 5:95 to 0.1:99.9; and fermenting the fermentable medium with a yeast that can tolerate an alcohol concentration of at least 10% by volume thereby preparing the neutral alcoholic malt base. A flavored malt beverage can include the neutral alcoholic malt base, water, at least one flavoring, a food grade acid, a sweetening agent, and carbon dioxide.
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