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公开(公告)号：US20110104362A1
公开(公告)日：2011-05-05
申请号：US13001630
申请日：2009-06-22
IPC分类号： A61K9/14
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.
摘要翻译： 制备具有沉积在颗粒表面上的表面改性纳米颗粒的活性药物成分颗粒的方法，所述方法包括：提供多个介质颗粒，所述介质颗粒具有沉积在表面上的表面改性纳米颗粒的表面; 将多个介质颗粒与活性成分颗粒混合，两者均为干燥形式，以提供活性成分颗粒，其表面具有沉积在表面上的表面改性纳米颗粒; 并且公开了将多个介质颗粒与具有表面改性的纳米颗粒沉积在表面上的具有表面的活性成分颗粒分离。
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2.发明申请公开(公告)号：US20110076336A1
公开(公告)日：2011-03-31
申请号：US12995319
申请日：2009-06-22
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/58
摘要： A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.
摘要翻译： 一种制备干粉药物组合物的方法，包括：提供无活性成分颗粒; 提供微粉化活性成分; 将非活性成分颗粒与表面改性的纳米颗粒混合以提供由表面与表面改性的纳米颗粒沉积在表面上的颗粒组成的非活性成分; 和/或将微粉化的活性成分与表面改性的纳米颗粒混合以提供微粉化的活性成分，其中包含具有沉积在表面上的表面改性纳米颗粒的表面的颗粒; 然后将微粉化活性成分与无活性成分混合; 通过该方法制备的干粉组合物; 所述组合物用于制备通过施用治疗量的干粉药物组合物而被递送至哺乳动物的肺的药物的用途，以及干粉吸入装置，其包括口部件，粉末容纳系统和 公开了干粉药物组合物。
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公开(公告)号：US09956170B2
公开(公告)日：2018-05-01
申请号：US12995319
申请日：2009-06-22
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/58
摘要： A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.
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公开(公告)号：US09861580B2
公开(公告)日：2018-01-09
申请号：US13001630
申请日：2009-06-22
IPC分类号： B05D1/28 , A61K9/14 , A61K9/00 , A61K31/137
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.
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公开(公告)号：US07659725B2
公开(公告)日：2010-02-09
申请号：US12293195
申请日：2007-03-22
CPC分类号： A61M15/009 , A61M2209/02
摘要： A method of assessing the suitability of a metered dose inhaler actuator A test canister equipped with a valve and containing a pressurized propellant is provided. One or more actuators manufactured for use in a metered dose inhaler is provided and tested, wherein each actuator is tested by coupling the canister to the actuator, positioning the actuator with respect to an electrostatic measurement device and firing the canister such that electrostatic charge from an aerosol emitted by the canister is measured by the electrostatic measurement device. The measured electrostatic charge is compared to a predetermined specification range to make a determination whether the measured electrostatic charge is within or outside the predetermined specification range and accordingly whether the actuator is or is not acceptable.
摘要翻译： 评估计量剂量吸入器致动器的适用性的方法提供了配备有阀并包含加压推进剂的测试罐。 提供并测试了用于定量吸入器中制造的一个或多个致动器，其中通过将所述罐连接到致动器来测试每个致动器，使致动器相对于静电测量装置定位并且对罐进行点火，使得来自 通过静电测量装置测量由罐发出的气溶胶。 将测量的静电电荷与预定的规格范围进行比较，以确定测量的静电电荷是否在预定规格范围内或之外，并且因此致动器是否是不可接受的。
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公开(公告)号：US09072664B2
公开(公告)日：2015-07-07
申请号：US12992633
申请日：2009-04-17
CPC分类号： A61K9/0075
摘要： Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added.
摘要翻译： 表现出改善的流动特性的粉末药物组合物是通过将平均粒度直径小于100nm的表面改性纳米颗粒的悬浮液在可干燥的液体载体中喷洒到药物组合物粉末成分的颗粒上而制成的。 液体载体被快速干燥，以使纳米颗粒留在粉末上。 还可以加入粉末药物组合物的其他成分。
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公开(公告)号：US20110064867A1
公开(公告)日：2011-03-17
申请号：US12992633
申请日：2009-04-17
IPC分类号： B05D3/00
CPC分类号： A61K9/0075
摘要： Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added.
摘要翻译： 表现出改善的流动特性的粉末药物组合物是通过将平均粒度直径小于100nm的表面改性纳米颗粒的悬浮液在可干燥的液体载体中喷射到药物组合物的粉末成分的颗粒上而制成的。 液体载体被快速干燥，以使纳米颗粒留在粉末上。 还可以加入粉末药物组合物的其他成分。
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公开(公告)号：US20090121722A1
公开(公告)日：2009-05-14
申请号：US12293195
申请日：2007-03-22
IPC分类号： G01R29/12
CPC分类号： A61M15/009 , A61M2209/02
摘要： A method of assessing the suitability of a metered dose inhaler actuator A test canister equipped with a valve and containing a pressurized propellant is provided. One or more actuators manufactured for use in a metered dose inhaler is provided and tested, wherein each actuator is tested by coupling the canister to the actuator, positioning the actuator with respect to an electrostatic measurement device and firing the canister such that electrostatic charge from an aerosol emitted by the canister is measured by the electrostatic measurement device. The measured electrostatic charge is compared to a predetermined specification range to make a determination whether the measured electrostatic charge is within or outside the predetermined specification range and accordingly whether the actuator is or is not acceptable.
摘要翻译： 评估计量剂量吸入器致动器的适用性的方法提供了配备有阀并包含加压推进剂的测试罐。 提供并测试了用于定量吸入器中制造的一个或多个致动器，其中通过将所述罐连接到致动器来测试每个致动器，使致动器相对于静电测量装置定位并且对罐进行点火，使得来自 通过静电测量装置测量由罐发出的气溶胶。 将测量的静电电荷与预定的规格范围进行比较，以确定测量的静电电荷是否在预定规格范围内或之外，并且因此致动器是否是不可接受的。
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