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1.发明申请公开(公告)号：US20110076336A1
公开(公告)日：2011-03-31
申请号：US12995319
申请日：2009-06-22
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/58
摘要： A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.
摘要翻译： 一种制备干粉药物组合物的方法，包括：提供无活性成分颗粒; 提供微粉化活性成分; 将非活性成分颗粒与表面改性的纳米颗粒混合以提供由表面与表面改性的纳米颗粒沉积在表面上的颗粒组成的非活性成分; 和/或将微粉化的活性成分与表面改性的纳米颗粒混合以提供微粉化的活性成分，其中包含具有沉积在表面上的表面改性纳米颗粒的表面的颗粒; 然后将微粉化活性成分与无活性成分混合; 通过该方法制备的干粉组合物; 所述组合物用于制备通过施用治疗量的干粉药物组合物而被递送至哺乳动物的肺的药物的用途，以及干粉吸入装置，其包括口部件，粉末容纳系统和 公开了干粉药物组合物。
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公开(公告)号：US20080114298A1
公开(公告)日：2008-05-15
申请号：US11718465
申请日：2005-11-18
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，包括具有附接到微针装置的凸起中心区域（115）的柔性片（110）和位于柔性片 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US08758298B2
公开(公告)日：2014-06-24
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列施用于哺乳动物的施用器。 特别是，一种用于将微针装置施加到皮肤表面上的应用装置，包括具有附接到微针装置的凸起中心区域的柔性片材和位于柔性片材的周边处或附近的支撑构件，其中柔性片材被配置为 它将在与片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US20110038918A1
公开(公告)日：2011-02-17
申请号：US12851808
申请日：2010-08-06
IPC分类号： A61K9/70 , A61K31/4468 , A61P29/00
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/7084 , A61K31/44 , A61K31/4468
摘要： A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.
摘要翻译： 透皮药物递送组合物包含丙烯酸酯共聚物和约8％至约30％重量的芬太尼。 还提供了包含月桂酸甲酯或四甘醇作为渗透促进剂的透皮芬太尼递送组合物。 透皮药物递送组合物可用于制备用于递送芬太尼的透皮药物递送装置。
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公开(公告)号：US20150246187A1
公开(公告)日：2015-09-03
申请号：US14430710
申请日：2013-09-24
发明人： Adam J Stuart , Adam S. Cantor
CPC分类号： A61M15/0001 , A61M15/0026 , A61M15/0065 , A61M2207/00 , C09J7/20 , C09J7/38 , C09J2201/28 , C09J2201/622 , C09J2400/24 , C09J2433/00
摘要： A dispensing assembly for a container filled with a medicinal substance or formulation, the container being suitable for administering the medicinal substance or formulation via inhalation, buccal or sublingual delivery. The dispensing assembly includes a housing (1) defining a patient port through which, in use, the medicinal substance or formulation is dispensed. The dispensing assembly further includes a cap (3) that can be engaged with and disengaged from the patient port to close and open the patient port and an adhesive tape (10) having one portion (12) affixed to the housing and a second portion (11) affixed to the cap, such that when the cap is disengaged from the patient port, the cap is still connected to the housing.
摘要翻译： 用于容纳药物或制剂的容器的分配组件，所述容器适于通过吸入，颊或舌下递送施用药物或制剂。 分配组件包括限定患者端口的壳体（1），在使用中，分配药物或制剂。 分配组件还包括能够与患者端口接合和脱离以关闭和打开患者口的帽（3），以及具有固定到壳体的一个部分（12）的粘合带（10）和第二部分 11）固定到盖上，使得当帽与患者端口脱离时，帽仍然连接到壳体。
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公开(公告)号：US20120034292A1
公开(公告)日：2012-02-09
申请号：US13275498
申请日：2011-10-18
IPC分类号： A61K31/4468 , A61P29/00 , A61K9/70
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/7084 , A61K31/44 , A61K31/4468
摘要： A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.
摘要翻译： 透皮药物递送组合物包含丙烯酸酯共聚物和约8重量％至约30重量％的芬太尼。 还提供了包含月桂酸甲酯或四甘醇作为渗透促进剂的透皮芬太尼递送组合物。 透皮药物递送组合物可用于制备用于递送芬太尼的透皮药物递送装置。
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公开(公告)号：US20100255073A1
公开(公告)日：2010-10-07
申请号：US12820280
申请日：2010-06-22
IPC分类号： A61K31/4468 , A61K9/70 , A61P25/04
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/7084 , A61K31/44 , A61K31/4468
摘要： A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.
摘要翻译： 透皮药物递送组合物包含丙烯酸酯共聚物和约8％至约30％重量的芬太尼。 还提供了包含月桂酸甲酯或四甘醇作为渗透促进剂的透皮芬太尼递送组合物。 透皮药物递送组合物可用于制备用于递送芬太尼的透皮药物递送装置。
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公开(公告)号：US06312715B1
公开(公告)日：2001-11-06
申请号：US09071667
申请日：1998-05-01
申请人： Adam S. Cantor , Hye-ok Choi , Joaquin Delgado , Chan U. Ko , Thu-Van Tran
发明人： Adam S. Cantor , Hye-ok Choi , Joaquin Delgado , Chan U. Ko , Thu-Van Tran
IPC分类号： A61F1302
CPC分类号： A61K9/7061 , A61K9/1617 , A61K9/1635 , A61K9/7092 , C08L2205/18 , C08L2666/28 , C09J133/06
摘要： Transdermal drug delivery compositions comprising pressure sensitive adhesive microspheres that contain a softening agent and/or a drug. Typically the microspheres contain at least 10 wt-% of a softening agent. The drug and/or softening agent can be incorporated into the microspheres during or after their formation.
摘要翻译： 透皮药物递送组合物包含含有软化剂和/或药物的压敏粘合剂微球。 通常，微球含有至少10重量％的软化剂。 药物和/或软化剂可在其形成期间或之后并入微球中。
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公开(公告)号：US09956170B2
公开(公告)日：2018-05-01
申请号：US12995319
申请日：2009-06-22
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/58
摘要： A method of making a dry powder pharmaceutical composition comprising: providing inactive ingredient particles; providing a micronized active ingredient; mixing the inactive ingredient particles with surface-modified nanoparticles to provide an inactive ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and/or mixing the micronized active ingredient with surface-modified nanoparticles to provide a micronized active ingredient comprised of particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and then mixing the micronized active ingredient with the inactive ingredient; the dry powder compositions made by the method; a use of said composition for the manufacture of a medicament for being delivered to the lungs of a mammal by administering a therapeutic amount of the dry powder pharmaceutical composition, and a dry powder inhalation device comprising a mouth piece, a powder containment system, and the dry powder pharmaceutical composition are disclosed.
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公开(公告)号：US20130006219A1
公开(公告)日：2013-01-03
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 一种用于将微针阵列施加到哺乳动物的施加器特别地，用于将微针装置施加到皮肤表面的施加装置包括具有附接到微针装置的凸起中心区域的柔性片和位于 柔性片，其中柔性片被构造成使得其将在与片的主平面正交的方向上进行逐步运动。
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