Peptide therapy for increasing platelet levels
    2.
    发明授权
    Peptide therapy for increasing platelet levels 有权
    肽治疗增加血小板水平

    公开(公告)号:US09427456B2

    公开(公告)日:2016-08-30

    申请号:US13378061

    申请日:2010-06-13

    IPC分类号: A61K38/19 A61P7/04 A61K38/10

    摘要: The present invention is directed to novel therapeutic uses of T-140 analog peptides and compositions comprising same. Specifically, the invention relates to compositions and methods for providing improved platelet levels, useful in the treatment and prevention of thrombocytopenia, for controlling bleeding and for inducing or modulating haemostasis.

    摘要翻译: 本发明涉及T-140类似物的新颖治疗用途及其组合物。 具体地,本发明涉及提供改善的血小板水平的组合物和方法,其用于治疗和预防血小板减少症,用于控制出血和诱导或调节止血。

    Peptides for inhibiting chemokine binding to chemokine receptors
    4.
    发明授权
    Peptides for inhibiting chemokine binding to chemokine receptors 有权
    用于抑制趋化因子结合趋化因子受体的肽

    公开(公告)号:US08383769B2

    公开(公告)日:2013-02-26

    申请号:US13274478

    申请日:2011-10-17

    IPC分类号: A61K38/00 A61K38/04 A61K45/00

    摘要: Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.

    摘要翻译: 用于调节趋化因子生物学作用的新型肽或拟肽剂或小分子。 根据本发明,治疗剂优选具有结合某些趋化因子的能力,以调节靶配体,趋化因子和各自的靶受体趋化因子受体之间的生物相互作用。 这些肽可以描述为激动剂配体或拮抗剂。 接下来,优选某些肽共享共有序列描述了这些调节肽的家族或类别的特征。

    PEPTIDES FOR INHIBITING CHEMOKINE BINDING TO CHEMOKINE RECEPTORS
    6.
    发明申请
    PEPTIDES FOR INHIBITING CHEMOKINE BINDING TO CHEMOKINE RECEPTORS 有权
    用于抑制化合物结合到化疗受体的肽

    公开(公告)号:US20120028913A1

    公开(公告)日:2012-02-02

    申请号:US13274478

    申请日:2011-10-17

    摘要: Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.

    摘要翻译: 用于调节趋化因子生物学作用的新型肽或拟肽剂或小分子。 根据本发明,治疗剂优选具有结合某些趋化因子的能力,以调节靶配体,趋化因子和各自的靶受体趋化因子受体之间的生物相互作用。 这些肽可以描述为激动剂配体或拮抗剂。 接下来,优选某些肽共享共有序列描述了这些调节肽的家族或类别的特征。

    Peptides for inhibiting chemokine binding to chemokine receptors
    7.
    发明授权
    Peptides for inhibiting chemokine binding to chemokine receptors 有权
    用于抑制趋化因子结合趋化因子受体的肽

    公开(公告)号:US08039440B2

    公开(公告)日:2011-10-18

    申请号:US12320281

    申请日:2009-01-22

    IPC分类号: A61K38/10 A61K39/00

    摘要: Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.

    摘要翻译: 用于调节趋化因子生物学作用的新型肽或拟肽剂或小分子。 根据本发明,治疗剂优选具有结合某些趋化因子的能力,以调节靶配体,趋化因子和各自的靶受体趋化因子受体之间的生物相互作用。 这些肽可以描述为激动剂配体或拮抗剂。 接下来,优选某些肽共享共有序列描述了这些调节肽的家族或类别的特征。

    Methods of inhibiting chemokine binding to chemokine receptors
    8.
    发明授权
    Methods of inhibiting chemokine binding to chemokine receptors 失效
    抑制趋化因子结合趋化因子受体的方法

    公开(公告)号:US07488717B2

    公开(公告)日:2009-02-10

    申请号:US10649873

    申请日:2003-08-28

    IPC分类号: A61K38/00 A61K39/00

    摘要: Novel peptides or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.

    摘要翻译: 用于调节趋化因子生物学效应的新型肽或拟肽剂或小分子。 根据本发明,治疗剂优选具有结合某些趋化因子的能力,以调节靶配体,趋化因子和各自的靶受体趋化因子受体之间的生物相互作用。 这些肽可以描述为激动剂配体或拮抗剂。 接下来,优选某些肽共享共有序列描述了这些调节肽的家族或类别的特征。