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1.发明申请Manufacture of Active Highly Phosphorylated Human Lysosomal Sulfatase Enzymes and Uses Thereof 有权活性高度磷酸化人溶酶体硫酸酯酶的制备及其用途公开(公告)号：US20090186011A1
公开(公告)日：2009-07-23
申请号：US12355453
申请日：2009-01-16
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
摘要翻译： 本发明提供活性高度磷酸化的溶酶体硫酸酯酶的组合物，其药物组合物，生产和纯化这些溶酶体硫酸酯酶的组合物及其组合物及其在诊断，预防或治疗疾病和病症中的用途，包括特别是溶酶体贮积病， 由溶酶体硫酸酯酶缺乏引起或与之相关。
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2.发明授权Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof 有权活性高度磷酸化人溶酶体硫酸酯酶的制备及其用途公开(公告)号：US08128925B2
公开(公告)日：2012-03-06
申请号：US12355453
申请日：2009-01-16
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
摘要翻译： 本发明提供活性高度磷酸化的溶酶体硫酸酯酶的组合物，其药物组合物，生产和纯化这些溶酶体硫酸酯酶的组合物及其组合物及其在诊断，预防或治疗疾病和病症中的用途，包括特别是溶酶体贮积病， 由溶酶体硫酸酯酶缺乏引起或与之相关。
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3.发明申请公开(公告)号：US20120208221A1
公开(公告)日：2012-08-16
申请号：US13371082
申请日：2012-02-10
IPC分类号： G01N21/64
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
摘要翻译： 本发明提供活性高度磷酸化的溶酶体硫酸酯酶的组合物，其药物组合物，生产和纯化这些溶酶体硫酸酯酶的组合物及其组合物及其在诊断，预防或治疗疾病和病症中的用途，包括特别是溶酶体贮积病， 由溶酶体硫酸酯酶缺乏引起或与之相关。
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4.发明授权公开(公告)号：US08420368B2
公开(公告)日：2013-04-16
申请号：US13371082
申请日：2012-02-10
申请人： Erno Pungor , Charles Hague , Zhi Chen
发明人： Erno Pungor , Charles Hague , Zhi Chen
IPC分类号： C12N9/14
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
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