Method and an apparatus for performing routine analyses such as
polarographic or spectrophotometric analysis

    公开(公告)号:US4673295A

    公开(公告)日:1987-06-16

    申请号:US850431

    申请日:1986-04-08

    摘要: In a method and an apparatus for performing routine analyses such as polarographic or spectrophotometric analysis on a large set of sample solutions filled into separate sample cups being arranged on or shaped in a sample cup holder (101) along a moving path, wherein the samples are in consecutive cycles sucked out of the sample cup (102) by a suction tube (103) and transferred into a common vessel, wherein the analysis will be performed. The vessel (105) has a lower outlet (107) communicating with an analyzer cell (112) or the ambient space over a channel (116) which is only effective if the sample level in the vessel (105) exceeds a certain threshold level, and an aspirating mouth (108) in the upper part of the vessel (105) communicating over a valve (109) with the ambient space. The suction tube (103) has a fixed end coupled to the inlet (106) of the vessel (105) and a free end can be moved into two different working positions. A continuous suction effect is exerted on the fixed end of the suction tube during the whole series of cycles whereas the free end of the suction tube is in the first phase of each cycle moved into its first working position wherein the free end is dipping into the next sample cup and being thus positioned opposite to the suction tube and in the second phase turned into its second working position wherein the free end is protruding into the ambient space. The analysis is performed when the level of the sample in the vessel has already exceeded a prescribed threshold level and at the end of the analysis operation an overpressure is established in the vessel. Then the suction tube, as the phase of the next following cycle, is moved again into its first working position and this series of operations is cyclically repeated.

    Recombinant human interferon-beta-1b polypeptides
    8.
    发明申请
    Recombinant human interferon-beta-1b polypeptides 审中-公开
    重组人干扰素-β-1b多肽

    公开(公告)号:US20050008616A1

    公开(公告)日:2005-01-13

    申请号:US10886414

    申请日:2004-07-06

    CPC分类号: C07K14/565 A61K38/00

    摘要: The present invention relates to recombinant human interferon-β-1b (“IFN-β-1b”) polypeptides, or fragments, analogs, derivatives, or variants thereof, having an improved specific activity. The present invention also relates to pharmaceutical compositions comprising such IFN-β-1b polypeptides, or fragments, analogs, derivatives, or variants thereof, useful for treating multiple sclerosis. The present invention further relates to methods of producing such IFN-β-1b compositions.

    摘要翻译: 本发明涉及具有改善的比活性的重组人干扰素-β-1b(“IFN-β-1b”)多肽或其片段,类似物,衍生物或变体。 本发明还涉及包含可用于治疗多发性硬化症的IFN-β-1b多肽或其片段,类似物,衍生物或变体的药物组合物。 本发明还涉及产生这种IFN-β-1b组合物的方法。

    Process and apparatus for the voltammetric measurement of the quantity
or mass of separated sample components
    9.
    发明授权
    Process and apparatus for the voltammetric measurement of the quantity or mass of separated sample components 失效
    用于分离样品成分的质量或质量的伏安测量的方法和装置

    公开(公告)号:US4066406A

    公开(公告)日:1978-01-03

    申请号:US677389

    申请日:1976-04-15

    CPC分类号: G01N27/42 G01N30/64

    摘要: A process and apparatus for the voltammetric measurement of sample component quantities is disclosed wherein the material to be measured is passed by means of a pulsating-delivery pump into a voltammetric cell by way of a flow cross-section restriction to the surface of the voltammetric electrode, the liquid jet being adjusted such that its cross-section in the vicinity of the measuring surface of the electrode should be greater than the measurement area of the latter. The obtained voltammetric current curve is integrated at the area below the peak value, the current changing as a function of the pulsating flow rate of the liquid and the material quantities are determined from the integrated data. Preferably, the integration is effected from a value corresponding to 50% of the maximum flow rate to the maximum value and from there again down to 50% of the flow rate maximum.