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1.发明申请SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 失效取代的二氢蝶啶-6-酮衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20110053944A1
公开(公告)日：2011-03-03
申请号：US12744770
申请日：2008-11-26
IPC分类号： A61K31/4985 , C07D475/04 , A61P35/00 , A61P37/02
CPC分类号： C07D475/00
摘要： Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（I）的二氢蝶啶-6-酮衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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2.发明授权Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors 失效取代的二氢蝶啶-6-酮衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08598172B2
公开(公告)日：2013-12-03
申请号：US12744770
申请日：2008-11-26
IPC分类号： A61K31/495 , C07D475/00
CPC分类号： C07D475/00
摘要： Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（I）的二氢蝶啶-6-酮衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US08227472B2
公开(公告)日：2012-07-24
申请号：US12444792
申请日：2007-10-09
IPC分类号： A61K31/497 , A61K31/445 , A61K31/415 , A01N43/40 , A01N43/56 , C07D403/00 , C07D211/32 , C07D231/54 , C07D487/02
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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公开(公告)号：US20100010008A1
公开(公告)日：2010-01-14
申请号：US12444792
申请日：2007-10-09
IPC分类号： A61K31/4162 , C07D487/04 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , C07D401/14 , A61K31/454 , A61K31/496 , C07D403/14
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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5.发明申请Substituted Pyrrolo-Pyrimidine Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors 有权取代的吡咯并嘧啶衍生物，其制备方法及其作为激酶抑制剂公开(公告)号：US20120122882A1
公开(公告)日：2012-05-17
申请号：US12679716
申请日：2008-09-25
申请人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Helena Posteri , Marina Caldarelli , Walter Ceccarelli , Barbara Valsasina
发明人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Helena Posteri , Marina Caldarelli , Walter Ceccarelli , Barbara Valsasina
IPC分类号： A61K31/506 , C07D471/04 , C07D403/14 , C12N9/99 , A61P31/12 , A61P25/28 , A61P37/06 , A61P31/18 , C07D403/04 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： Substituted pyrrolo-pyrimidine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的取代的吡咯并 - 嘧啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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公开(公告)号：US08623876B2
公开(公告)日：2014-01-07
申请号：US13495688
申请日：2012-06-13
IPC分类号： A61K31/497 , A01N43/40 , A61K31/445 , A01N43/56 , A61K31/415 , C07D211/32 , C07D231/54 , C07D487/02
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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7.发明授权Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权取代的吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08614220B2
公开(公告)日：2013-12-24
申请号：US12520842
申请日：2007-12-17
申请人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Ron Ferguson , Helena Posteri , Barbara Valsasina
发明人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Ron Ferguson , Helena Posteri , Barbara Valsasina
IPC分类号： A61K31/519 , C07D239/70
CPC分类号： C07D487/04 , C07D295/135 , C07D295/155 , C40B40/04 , C40B50/14
摘要： Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（I）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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8.发明授权Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors 有权取代的吡咯并嘧啶衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08426417B2
公开(公告)日：2013-04-23
申请号：US12679716
申请日：2008-09-25
申请人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Helena Posteri , Marina Caldarelli , Walter Ceccarelli , Barbara Valsasina
发明人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Helena Posteri , Marina Caldarelli , Walter Ceccarelli , Barbara Valsasina
IPC分类号： C07D403/04 , C07D471/04 , A61K31/506
CPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： Substituted pyrrolo-pyrimidine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的取代的吡咯并 - 嘧啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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9.发明申请SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代的吡唑并喹啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20100216808A1
公开(公告)日：2010-08-26
申请号：US12520842
申请日：2007-12-17
申请人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Ronald Ferguson , Helena Posteri , Barbara Valsasina
发明人： Michele Caruso , Italo Beria , Maria Gabriella Brasca , Ronald Ferguson , Helena Posteri , Barbara Valsasina
IPC分类号： A61K31/519 , C07D487/04 , C07D295/155 , A61P31/18 , A61P37/06 , A61P35/00 , A61P31/12 , A61P25/28 , A61P19/02 , A61P9/10 , A61P17/06 , C40B40/04
CPC分类号： C07D487/04 , C07D295/135 , C07D295/155 , C40B40/04 , C40B50/14
摘要： Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（I）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与抑制性蛋白激酶活性相关的疾病，如癌症。
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10.发明授权Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds 有权蒽环类衍生物缀合物，其制备方法及其作为抗肿瘤化合物的用途公开(公告)号：US08389697B2
公开(公告)日：2013-03-05
申请号：US13360212
申请日：2012-01-27
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： C07H15/24
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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