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1.发明授权Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds 有权蒽环类衍生物缀合物，其制备方法及其作为抗肿瘤化合物的用途公开(公告)号：US08900589B2
公开(公告)日：2014-12-02
申请号：US12502433
申请日：2009-07-14
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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公开(公告)号：US08470984B2
公开(公告)日：2013-06-25
申请号：US13308799
申请日：2011-12-01
申请人： Michele Caruso , Vittoria Lupi , Matteo Salsa
发明人： Michele Caruso , Vittoria Lupi , Matteo Salsa
IPC分类号： C07H15/24
CPC分类号： C07H15/244 , C07H1/00 , C07H19/24
摘要： The present invention provides a process for the preparation of a morpholinyl anthracycline derivative in good yields and purity, including 3′-deamino-3″-4′-anhydro-[2″(S)-methoxy-3″(R)-hydroxy-4″-morpholinyl]doxorubicin (1).
摘要翻译： 本发明提供了一种以良好的产率和纯度制备吗啉基蒽环类衍生物的方法，包括3'-脱氨基-3“-4'-脱水 - [2”（S） - 甲氧基-3“（R ） - 羟基-4“ - 吗啉基]多柔比星（1）。
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3.发明申请ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 有权蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途公开(公告)号：US20100034837A1
公开(公告)日：2010-02-11
申请号：US12502433
申请日：2009-07-14
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： A61K31/704 , C07H15/24 , C07K16/46 , C07K14/00 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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4.发明授权Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds 有权蒽环类衍生物缀合物，其制备方法及其作为抗肿瘤化合物的用途公开(公告)号：US08389697B2
公开(公告)日：2013-03-05
申请号：US13360212
申请日：2012-01-27
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： C07H15/24
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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公开(公告)号：US20120142906A1
公开(公告)日：2012-06-07
申请号：US13308799
申请日：2011-12-01
申请人： Michele Caruso , Vittoria Lupi , Matteo Salsa
发明人： Michele Caruso , Vittoria Lupi , Matteo Salsa
CPC分类号： C07H15/244 , C07H1/00 , C07H19/24
摘要： The present invention provides a process for the preparation of a morpholinyl anthracycline derivative in good yields and purity, including 3′-deamino-3″-4′-anhydro-[2″(S)-methoxy-3″(R)-hydroxy-4″-morpholinyl]doxorubicin (1).
摘要翻译： 本发明提供以良好的产率和纯度制备吗啉基蒽环类衍生物的方法，包括3'-脱氨基-3“-4'-脱水 - [2”（S） - 甲氧基-3“（R） - 羟基 -4“ - 吗啉基]多柔比星（1）。
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6.发明申请ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 有权蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途公开(公告)号：US20120130059A1
公开(公告)日：2012-05-24
申请号：US13360212
申请日：2012-01-27
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： C07H15/26 , C07H15/252
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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