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1.发明申请公开(公告)号：US20090275546A1
公开(公告)日：2009-11-05
申请号：US12386002
申请日：2009-04-10
IPC分类号： A61K31/395 , C40B30/06 , C12N5/02
CPC分类号： G01N33/57419 , A61K31/00 , A61K31/395 , G01N33/57496 , G01N2333/485 , G01N2333/71 , G01N2800/52
摘要： Provided are methods of identifying a metabolic target in a cancer stem cell that include using a microarray to identify intracellular signaling networks within a population of cancer stem cells that respond to a growth factor for the stem cell. Also provided are methods of determining a personalized therapeutic regime that include receiving metabolic information relating to a cancer stem cell in a patient, determining the patient's personal criteria relevant to the therapeutic regime, and combining the metabolic and personal criteria. Also provided are a diagnostic test for establishing a personalized therapeutic regime for a colon cancer patient and methods of reducing colon cancer stem cells/treating colon cancer.
摘要翻译： 提供了确定癌症干细胞中的代谢靶标的方法，其包括使用微阵列来鉴定响应干细胞生长因子的癌干细胞群体内的细胞内信号传导网络。 还提供了确定个体化治疗方案的方法，其包括接收与患者中的癌干细胞相关的代谢信息，确定患者与治疗方案相关的个人标准，以及组合代谢和个人标准。 还提供了建立结肠癌患者的个性化治疗方案的诊断测试和减少结肠癌干细胞/治疗结肠癌的方法。
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公开(公告)号：US20110137627A1
公开(公告)日：2011-06-09
申请号：US12959096
申请日：2010-12-02
CPC分类号： G16B5/00
摘要： A system and method for creating at least one new network, comprising: selecting at least one node and at least one set of reactions where reagents in each reaction of the at least one set of reactions are known in at least one reference network; and creating at least one new network by causing the at least one new network to behave in a similar way with respect to the at least one node and the at least one set of reactions as the at least one reference network reacts with the at least one node and the at least one set of reactions.
摘要翻译： 一种用于创建至少一个新网络的系统和方法，包括：选择至少一个节点和至少一组反应，其中所述至少一组反应的每个反应中的试剂在至少一个参考网络中是已知的; 以及通过使所述至少一个新网络相对于所述至少一个节点以及所述至少一个反馈集合以类似的方式行为来创建至少一个新网络，因为所述至少一个参考网络与所述至少一个参考网络反应 节点和至少一组反应。
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