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1.发明申请Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents 审中-公开用于阴道递送治疗有效和/或健康促进剂的涂层阴道装置公开(公告)号：US20050276836A1
公开(公告)日：2005-12-15
申请号：US11180076
申请日：2005-07-12
申请人： Michelle Wilson , Kishorkumar J. Desai , Giovanni M. Pauletti , Mitchell K. Antoon , Chris Clendening
发明人： Michelle Wilson , Kishorkumar J. Desai , Giovanni M. Pauletti , Mitchell K. Antoon , Chris Clendening
CPC分类号： A61F13/2051 , A61F13/8405 , A61F2013/8414 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/19 , A61K9/7007
摘要： A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.
摘要翻译： 用于递送治疗和/或健康促进剂的阴道装置。 阴道装置部分地或完全被涂层，覆盖或与包括膜，泡沫，条，帽，杯或颗粒的涂层或覆盖物组合。 该装置的涂层包括包含治疗和/或健康促进剂的粘膜粘附组合物。
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2.发明授权公开(公告)号：US08178123B2
公开(公告)日：2012-05-15
申请号：US11522126
申请日：2006-09-15
IPC分类号： A61F2/02
CPC分类号： A61K36/61 , A61K9/0034 , A61K9/006 , A61K9/02 , A61K9/122 , A61K36/16 , A61K36/185 , A61K36/235 , A61K36/24 , A61K36/254 , A61K36/258 , A61K36/28 , A61K36/324 , A61K36/38 , A61K36/48 , A61K36/537 , A61K36/54 , A61K36/67 , A61K36/71 , A61K36/734 , A61K36/752 , A61K36/77 , A61K36/82 , A61K36/84 , A61K36/87 , A61K36/889 , A61K36/8962 , A61K36/906 , A61K36/9066 , A61K36/9068 , B33Y80/00 , A61K2300/00
摘要： A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
摘要翻译： 对代谢细胞色素P-450酶和膜外排运输系统具有底物亲和力的治疗剂的阴道或口腔递送。 通过将所述药物通过阴道或颊粘膜递送至全身循环，增加对细胞色素P-450酶和膜外排转运体系具有底物亲和力的治疗剂的全身暴露的方法。
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公开(公告)号：US07341737B2
公开(公告)日：2008-03-11
申请号：US10335759
申请日：2002-12-31
申请人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
发明人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
CPC分类号： A61M31/00 , A61F13/202 , A61F13/2051 , A61F13/2074 , A61F13/28 , A61F13/8405 , A61F2013/8414 , A61F2013/8417 , A61K9/0036 , A61K9/025 , A61M2210/1475 , Y10S514/966 , Y10S514/967
摘要： A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
摘要翻译： 一种适于递送治疗剂的卫生棉条，所述棉塞包括具有远端的棉塞本体; 以及固定在卫生栓体的远端的剂型，其中所述剂型包括包含治疗剂的制剂，并且其中所述剂型包含多个层。 另外，一种适于输送治疗剂的药物棉塞的制造方法，其特征在于，包括制造具有前端的棉塞体; 制备具有多个层的剂型，其中所述剂型包括包含治疗剂的制剂; 并将剂型固定在棉塞体的远端。
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4.发明授权公开(公告)号：US07744916B2
公开(公告)日：2010-06-29
申请号：US11126863
申请日：2005-05-10
申请人： Giovanni M. Pauletti , Michelle Wilson , Richard Soderstrom , Desai J. Kishorkumar , Wolfgang A. Ritschel
发明人： Giovanni M. Pauletti , Michelle Wilson , Richard Soderstrom , Desai J. Kishorkumar , Wolfgang A. Ritschel
CPC分类号： A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
摘要： A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.
摘要翻译： 用于通过阴道粘膜递送抗偏头痛或抗恶心药物到子宫和/或一般循环的阴道装置。 该装置至少部分地涂覆有形成具有包含抗偏头痛或抗恶心药物的粘膜粘附组合物的帽，膜，泡沫，箔或条的一层或几层流体不可渗透材料。
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5.发明授权公开(公告)号：US07939098B2
公开(公告)日：2011-05-10
申请号：US10444634
申请日：2003-05-22
CPC分类号： A61K31/663 , A61K9/0034 , A61K9/0036 , A61K9/0043 , A61K9/0056 , A61K9/006 , A61K9/02 , A61K31/192 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/405 , A61K31/407 , A61K31/5415 , A61K31/616 , A61K38/00 , A61K45/06 , A61K47/10
摘要： Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a non-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long-term preservation of cell or embryos.
摘要翻译： 用于阴道，口腔或鼻粘膜递送药物和冷冻保护细胞和胚胎的组合物和方法。 对于冷冻保护，组合物基本上由不可离子化的二醇衍生物组成。 对于经粘膜递送，组合物基本上由与药物活性剂组合的不可离子化的二醇衍生物组成。 对于经粘膜递送，可将非离子化的二醇衍生物进一步与粘膜粘附剂和/或渗透增强剂和/或亲脂性或亲水性载体组合，以粘附和输送通过粘膜。 组合物特别适用于通过鼻，口腔和阴道粘膜施用药物或用于长期保存细胞或胚胎。
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公开(公告)号：US06905701B2
公开(公告)日：2005-06-14
申请号：US10349029
申请日：2003-01-22
IPC分类号： A61F20060101 , A61F6/06 , A61F6/08 , A61F13/00 , A61F13/02 , A61K9/00 , A61K9/02 , A61K31/66 , A61M20060101 , A61P19/00
CPC分类号： A61K31/66 , A61F6/08 , A61F6/12 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/06 , A61K9/2018 , A61K9/2054 , A61K31/663
摘要： Devices, methods, and improved formulation for transmucosal vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the systemic circulation using a vaginal device comprising an improved bisphosphonate formulation for transmucosal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transmucosal delivery of bisphosphonates to the general circulation.
摘要翻译： 双膦酸盐的经粘膜阴道分泌物的装置，方法和改进的制剂。 使用包含用于经粘膜递送的改进的双膦酸盐制剂的阴道装置将双膦酸盐靶向位点递送至全身循环。 一种治疗骨质疏松症及相关骨骼和骨骼疾病的方法，用于通过阴道内施用双膦酸盐对阴道和双膦酸盐向一般循环的经粘膜递送来预防骨分解和骨量丧失和强度。
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公开(公告)号：US06982091B2
公开(公告)日：2006-01-03
申请号：US10226667
申请日：2002-08-21
CPC分类号： A61K9/0034 , A61K9/0036
摘要： Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
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公开(公告)号：US06572874B1
公开(公告)日：2003-06-03
申请号：US09626025
申请日：2000-07-27
IPC分类号： A61F606
CPC分类号： A61K9/0036 , A61F6/08 , A61K9/0034 , A61K9/02
摘要： Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.
摘要翻译： 双膦酸盐阴道分泌物的装置，方法和组合物。 使用包含配制用于经阴道递送的二膦酸盐组合物的药物阴道装置将双膦酸盐靶向位点递送至阴道。 一种治疗骨质疏松症和相关骨骼和骨骼疾病的方法，用于通过阴道内给予双膦酸盐至阴道和经阴道分泌双膦酸盐至一般循环来预防骨质破坏和骨量丧失和强度。
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公开(公告)号：US20090297585A1
公开(公告)日：2009-12-03
申请号：US12130279
申请日：2008-05-30
IPC分类号： A61F13/20 , A61K47/40 , A61K47/38 , A61K47/34 , A61K47/46 , B05C11/00 , A61K9/00 , A61F13/02
CPC分类号： A61K9/7007
摘要： pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.
摘要翻译： pH调制膜及其制备方法。 膜组合物包含至少一种与水结合时具有非中性pH的组分; 以及当与非水性介质组合时与非中性组分组合时选择的pH调节聚合物体系来减少或防止协同作用。 这些电影表现出非自我聚集均匀的异质性。 理想地，膜在水中分解并且可以通过受控的干燥过程，挤出工艺或维持膜所需的均匀性的其它方法形成。
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