公开(公告)号：US08563504B2

公开(公告)日：2013-10-22

申请号：US13122190

申请日：2009-10-09

申请人： Miguel Ângelo da Costa Garcia ,  Madalena Maria Vilela Pimentel ,  Carlos Jorge Sousa de São José

发明人： Miguel Ângelo da Costa Garcia ,  Madalena Maria Vilela Pimentel ,  Carlos Jorge Sousa de São José

IPC分类号： A01N37/18

CPC分类号： C12N9/503 ,  C07K2319/00 ,  C12N2795/10311 ,  C12N2795/10322

摘要： The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.

摘要翻译： 本发明涉及具有抗生素活性的噬菌体来源的分离和嵌合多肽及其在治疗和控制细菌感染中的用途。 具体而言，本发明涉及来自噬菌体F87s / 06及其嵌合构建体的新型抗菌多肽及其用于治疗和控制由革兰氏阳性菌（包括金黄色葡萄球菌）引起的感染的用途。

公开(公告)号：US20110230393A1

公开(公告)日：2011-09-22

申请号：US13122190

申请日：2009-10-09

申请人： Miguel Angelo Da Costa Garcia ,  Madalena Maria Vilela Pimentel ,  Carlos Jorge Sousa de São José

发明人： Miguel Angelo Da Costa Garcia ,  Madalena Maria Vilela Pimentel ,  Carlos Jorge Sousa de São José

IPC分类号： A61K38/16 ,  C07K14/195 ,  C07H21/04 ,  C12N15/63 ,  C12N1/00 ,  C12N5/10 ,  A61P31/04

CPC分类号： C12N9/503 ,  C07K2319/00 ,  C12N2795/10311 ,  C12N2795/10322

摘要： The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.

摘要翻译： 本发明涉及具有抗生素活性的噬菌体来源的分离和嵌合多肽及其在治疗和控制细菌感染中的用途。 具体而言，本发明涉及来自噬菌体F87s / 06及其嵌合构建体的新型抗菌多肽及其用于治疗和控制由革兰氏阳性菌（包括金黄色葡萄球菌）引起的感染的用途。