Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3,
17-dione amid 14.alpha.-hydroxy-4-androstene-3,6,17-trione from
4-androstene-3, 17-dione using myrothecium sp. ferm bp-4432
    3.
    发明授权
    Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3, 17-dione amid 14.alpha.-hydroxy-4-androstene-3,6,17-trione from 4-androstene-3, 17-dione using myrothecium sp. ferm bp-4432 失效
    使用来自4-雄甾烯-3,17-二酮的14α-羟基-4-雄甾烯-3,17,17-二酮中的6β,14α-二羟基-4-雄甾烯-3,17-二酮的制备方法,使用脯氨酸 。 ferm bp-4432

    公开(公告)号:US5378611A

    公开(公告)日:1995-01-03

    申请号:US154857

    申请日:1993-11-19

    摘要: The invention provides a novel process for the production of 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione which comprises culturing a microorganism belonging to the genus Myrothecium and capable of hydrolyzing 4-androstene-3,17-dione to produce 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione in a medium supplemented with 4-androstene-3,17-dione, and isolating 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione from the cultured medium. According to the process of the present invention, 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione and 14.alpha.-hydroxy-4-androstene-3,6,17-trione can be produced with a high yield in a simple manner.

    摘要翻译: 本发明提供了生产6β,14α-二羟基-4-雄甾烯-3,17-二酮的新方法,该方法包括培养属于黑腹菌属的微生物并能够水解4-雄甾烯-3,17-二酮 在补充有4-雄甾烯-3,17-二酮的培养基中产生6β,14α-二羟基-4-雄甾烯-3,17-二酮,并分离6β,14α-二羟基-4-雄甾烯-3, 17二酮从培养基中。 根据本发明的方法,可以高产率制备6β,14α-二羟基-4-雄甾烯-3,17-二酮和14α-羟基-4-雄甾烯-3,6,17-三酮 以简单的方式。