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    Diagnosis of collagen IX destruction
    1.
    发明授权
    Diagnosis of collagen IX destruction 失效
    诊断胶原IX破坏

    公开(公告)号：US08580529B2

    公开(公告)日：2013-11-12

    申请号：US12928884

    申请日：2010-12-22

    申请人： Mikael Danfelter ,  Patrik Önnerfjord ,  Dick Heinegård

    发明人： Mikael Danfelter ,  Patrik Önnerfjord ,  Dick Heinegård

    IPC分类号： G01N31/00 ,  G01N33/53

    CPC分类号： G01N33/6887 ,  C07K14/78 ,  G01N2333/78 ,  G01N2800/10

    摘要： A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the neoepitopes were created by the cleavages and an epitope in the cleaved N-terminal part of the NC4 domain unique to collagen IX. A diagnostic kit and antibodies useful in carrying out such methods are also presented.

    摘要翻译： 用于检测或监测蛋白质片段的存在的方法，其在胶原IXα1链的N末端附近的接近NC4结构域的C末端部分附近的切割位点和接近于 NC3域。 通过切割和在胶原IX独特的NC4结构域的切割的N-末端部分中的表位产生针对新表皮的Neoepitope抗体。 还提供了诊断试剂盒和用于实施这些方法的抗体。

    METHOD TO DETECT TISSUE DEGRADATION LEADING TO INFLAMMATION
    3.
    发明申请
    METHOD TO DETECT TISSUE DEGRADATION LEADING TO INFLAMMATION 审中-公开
    检测导致炎症的组织降解的方法

    公开(公告)号：US20130084584A1

    公开(公告)日：2013-04-04

    申请号：US13636145

    申请日：2011-03-30

    申请人： Anna Blom ,  Kaisa Happonen ,  Dick Heinegård ,  Tore Saxne

    发明人： Anna Blom ,  Kaisa Happonen ,  Dick Heinegård ,  Tore Saxne

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2800/102

    摘要： This invention relates generally to a method, an assay and a kit for determining a tissue degradation process that leads to inflammatory responses opening up for a vicious circle of increased tissue destruction. More specifically the invention relates to kits and methods for an assay that can analyzee human samples, for the presence of a COMP fragment complex that have activated complement exemplified by the complex between COMP and complement factor C3b or natural breakdown fragments of C3b.

    摘要翻译： 本发明一般涉及一种用于确定组织降解过程的方法，测定和试剂盒，其导致炎症反应对于增加组织破坏的恶性循环而开放。 更具体地，本发明涉及用于可以分析人样品的测定的试剂盒和方法，其中存在具有活化补体的COMP片段复合物，例如由COMP和补体因子C3b之间的复合物或C3b的天然分解片段组成。

    Monoclonal antibodies for cartillage oligomeric matrix protein
    5.
    发明授权
    Monoclonal antibodies for cartillage oligomeric matrix protein 有权
    用于软骨寡聚基质蛋白的单克隆抗体

    公开(公告)号：US08110663B2

    公开(公告)日：2012-02-07

    申请号：US12768614

    申请日：2010-04-27

    申请人： Dick Heinegård

    发明人： Dick Heinegård

    IPC分类号： G01N33/533

    CPC分类号： G01N33/6887

    摘要： The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also relates to three particularly advantageous monoclonal antibodies per se that are directed against human COMP. Cell cultures manufacturing these antibodies have been deposited according to the Budapest Treaty at Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH, and have been assigned accesion numbers DSM ACC2406, DSM ACC2408 and DSM ACC2418, respectively. A diagnostic kit comprising at least two of these monoclonal antibodies also constitute a part of the present invention.

    摘要翻译： 本发明提供用于确定临床样品中COMP的存在的新的敏感直接夹心测定法。 在测定中使用针对COMP分子的分离的抗原决定簇的两种单克隆抗体。 本发明还涉及针对人COMP的三种特别有利的单克隆抗体本身。 制造这些抗体的细胞培养物已经根据布达佩斯条约在Deutsche Sammlung von Mikroorganismen和Zellkulturen GmbH进行保藏，并分别被分配到DSM ACC2406，DSM ACC2408和DSM ACC2418。 包含这些单克隆抗体中的至少两种的诊断试剂盒也构成本发明的一部分。