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1.发明授权Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions 失效软骨中间层蛋白2 C1及其用于分化骨关节炎与类风湿性关节炎和非疾病状况的用途公开(公告)号：US08663944B2
公开(公告)日：2014-03-04
申请号：US12806590
申请日：2010-08-17
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , C07K14/78 , C07K16/18 , G01N2800/102 , G01N2800/105
摘要： A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2 (CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments thereof.
摘要翻译： 一种在样品中分化类风湿关节炎和非疾病状况的骨关节炎的方法，包括在样品中测量体液中人软骨中间层蛋白2（CILP-2）的浓度，更具体地，在样品中测量浓度 的CILP-2（2C1）的N-末端部分或其片段。
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2.发明申请Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions 有权软骨中间层蛋白2 C1及其用于分化骨关节炎与类风湿性关节炎和非疾病状况的用途公开(公告)号：US20080241851A1
公开(公告)日：2008-10-02
申请号：US11728857
申请日：2007-03-27
申请人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
发明人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/00 , G01N33/566 , C07K16/18
CPC分类号： G01N33/6893 , C07K14/78 , C07K16/18 , G01N2800/102 , G01N2800/105
摘要： A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2(CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments thereof.
摘要翻译： 一种在样品中分化类风湿关节炎和非疾病状况的骨关节炎的方法，包括在样品中测量体液中人软骨中间层蛋白2（CILP-2）的浓度，更具体地，在样品中测量浓度 的CILP-2（2C1）的N-末端部分或其片段。
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3.发明申请Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions 失效软骨中间层蛋白2 C1及其用于分化骨关节炎与类风湿性关节炎和非疾病状况的用途公开(公告)号：US20110076708A1
公开(公告)日：2011-03-31
申请号：US12806590
申请日：2010-08-17
申请人： Pilar Lorenzo , Tore Saxne , Dick Heinegård
发明人： Pilar Lorenzo , Tore Saxne , Dick Heinegård
IPC分类号： C12Q1/42 , G01N33/573 , C07K16/40 , C12N9/16
CPC分类号： G01N33/6893 , C07K14/78 , C07K16/18 , G01N2800/102 , G01N2800/105
摘要： A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2 (CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments thereof.
摘要翻译： 一种在样品中分化类风湿关节炎和非疾病状况的骨关节炎的方法，包括在样品中测量体液中人软骨中间层蛋白2（CILP-2）的浓度，更具体地，在样品中测量浓度 的CILP-2（2C1）的N-末端部分或其片段。
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4.发明授权Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions 有权软骨中间层蛋白2 C1及其用于分化骨关节炎与类风湿性关节炎和非疾病状况的用途公开(公告)号：US07812125B2
公开(公告)日：2010-10-12
申请号：US11728857
申请日：2007-03-27
申请人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
发明人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
CPC分类号： G01N33/6893 , C07K14/78 , C07K16/18 , G01N2800/102 , G01N2800/105
摘要： A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2(CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments thereof.
摘要翻译： 一种在样品中分化类风湿关节炎和非疾病状况的骨关节炎的方法，包括在样品中测量体液中人软骨中间层蛋白2（CILP-2）的浓度，更具体地，在样品中测量浓度 的CILP-2（2C1）的N-末端部分或其片段。
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5.发明申请Peptide for differentiating osteoarthritis from rheumatoid arthritis and non-disease conditions 审中-公开用于分化骨关节炎与类风湿性关节炎和非疾病状况的肽公开(公告)号：US20080241945A1
公开(公告)日：2008-10-02
申请号：US11728856
申请日：2007-03-27
申请人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
发明人： Pilar Lorenzo , Tore Saxne , Dick Heinegard
CPC分类号： C07K16/18 , C07K14/78 , G01N33/564 , G01N33/6887 , G01N2333/78 , G01N2800/102 , G01N2800/105
摘要： A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of a peptide comprising the 15 amino acid sequence (SEQ ID NO: 1) of the human cartilage intermediate layer protein 2.
摘要翻译： 一种用于在样品中分化骨关节炎与类风湿性关节炎和非疾病状况的方法，包括在样品中测量包含人软骨中间层蛋白2的15个氨基酸序列（SEQ ID NO：1）的肽的浓度。
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公开(公告)号：US07211649B1
公开(公告)日：2007-05-01
申请号：US10349188
申请日：2003-01-23
申请人： Dick Heinegard , Pilar Lorenzo
发明人： Dick Heinegard , Pilar Lorenzo
摘要： A novel, N-oligosaccharide-substituted-specific protein of approximately 91.5 kDa was purified from extracts of human articular cartilage and designated Cartilage Intermediate Layer Protein (CILP). The protein is a chondrocyte product which is deposited in the interterritorial matrix. The gene encoding CILP, as well as its mRNA, were isolated and characterized. A single 4.2 kb mRNA detected in human articular cartilage encodes a polypeptide of 1184 amino acids with a calculated molecular weight of 132.5 kDa. The protein has a putative signal peptide of 21 amino acids, and is a proform of two polypeptides. The amino-terminal half corresponds to CILP (molecular weight of 78.5 kDa, not including post-translational modifications) and the carboxy-terminal half corresponds to a protein homologous to a porcine nucleotide pyrophosphohydrolase, NTPPHase (molecular weight of 51.8 kDa, not including post-translational modifications).
摘要翻译： 从人关节软骨和指定软骨中间层蛋白（CILP）的提取物中纯化约91.5kDa的新型N-寡糖取代特异性蛋白质。 该蛋白质是一种软骨细胞产品，其沉积在间质基质中。 分离和表征编码CILP的基因及其mRNA。 在人关节软骨中检测到的单个4.2kb mRNA编码1184个氨基酸的多肽，计算分子量为132.5kDa。 该蛋白具有21个氨基酸的推定信号肽，并且是两个多肽的形式。 氨基末端一半对应于CILP（分子量为78.5kDa，不包括翻译后修饰），羧基末端一半对应于与猪核苷酸焦磷酸水解酶NTPPHase（分子量为51.8kDa，不包括柱 翻译修饰）。
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