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公开(公告)号：US08663910B2
公开(公告)日：2014-03-04
申请号：US12562885
申请日：2009-09-18
IPC分类号： C12Q1/00
CPC分类号： G01N33/54366
摘要： A plurality of kinds of liquids, which are of at least three kinds, containing (a) a test body solution containing at least one kind of an analyte, and (b) at least two kinds of liquids selected from the group consisting of a reagent solution, an amplifying solution, and a detecting solution, are fed to a detection site containing a specific binding substance with respect to the analyte. A qualitative analysis or a quantitative analysis of the analyte contained in the test body solution is thereby performed. Directions of liquid feeding of all of the plurality of the kinds of the liquids vary from one another, and the plurality of the kinds of the liquids are caused to intersect with one another at the detection site.
摘要翻译： 至少三种的多种液体，其含有（a）含有至少一种分析物的测试体溶液，和（b）至少两种选自试剂 溶液，放大溶液和检测溶液相对于分析物进料到含有特异性结合物质的检测部位。 因此，进行了测试体溶液中包含的分析物的定性分析或定量分析。 所有多种液体的液体供给方向彼此不同，并且使多种液体在检测部位彼此相交。
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公开(公告)号：US20100075440A1
公开(公告)日：2010-03-25
申请号：US12562885
申请日：2009-09-18
IPC分类号： G01N33/543
CPC分类号： G01N33/54366
摘要： A plurality of kinds of liquids, which are of at least three kinds, containing (a) a test body solution containing at least one kind of an analyte, and (b) at least two kinds of liquids selected from the group consisting of a reagent solution, an amplifying solution, and a detecting solution, are fed to a detection site containing a specific binding substance with respect to the analyte. A qualitative analysis or a quantitative analysis of the analyte contained in the test body solution is thereby performed. Directions of liquid feeding of all of the plurality of the kinds of the liquids vary from one another, and the plurality of the kinds of the liquids are caused to intersect with one another at the detection site.
摘要翻译： 至少三种的多种液体，其含有（a）含有至少一种分析物的测试体溶液，和（b）至少两种选自试剂 溶液，放大溶液和检测溶液相对于分析物进料到含有特异性结合物质的检测部位。 因此，进行了测试体溶液中包含的分析物的定性分析或定量分析。 所有多种液体的液体供给方向彼此不同，并且使多种液体在检测部位彼此相交。
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公开(公告)号：US08765457B2
公开(公告)日：2014-07-01
申请号：US13262526
申请日：2010-03-30
申请人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
发明人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
IPC分类号： B01L3/00 , G01N33/543
摘要： A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.
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公开(公告)号：US08802426B2
公开(公告)日：2014-08-12
申请号：US13262526
申请日：2010-03-30
申请人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
发明人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： G01N33/54386
摘要： A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.
摘要翻译： 用于测定的装置可以均匀地开发溶液，并进行高度精确和灵敏的测量。 第一装置部分（10）以这样的方式保持第二不溶性载体（12）和第三不溶性载体（13），使得它们在第一不溶性载体（11）的检测部分（14）处彼此重叠。 这三个载体（11），（12）和（13）彼此不接触地容纳。 在与检测部（14）相对的第二装置部（20）的内表面上设置有具有与检测部（14）平行的按压面（18a）的按压部（18）。 按压面（18a）通过朝向检测部（14）被按压而移位，从第一不溶性载体（11）的上侧按压第二不溶性载体（12）和第三不溶性载体（13） 到第一不溶性载体（11）上。 第一装置部件（10）和第二装置部件（20）连接在一起。
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公开(公告)号：US20120058465A1
公开(公告)日：2012-03-08
申请号：US13262526
申请日：2010-03-30
申请人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
发明人： Mikinaga Mori , Junichi Katada , Takayoshi Oyamada , Hideyuki Karaki , Masayasu Konishi , Hiroki Terada
CPC分类号： G01N33/54386
摘要： A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.
摘要翻译： 用于测定的装置可以均匀地开发溶液，并进行高度精确和灵敏的测量。 第一装置部分（10）以这样的方式保持第二不溶性载体（12）和第三不溶性载体（13），使得它们在第一不溶性载体（11）的检测部分（14）处彼此重叠。 这三个载体（11），（12）和（13）彼此不接触地容纳。 在与检测部（14）相对的第二装置部（20）的内表面上设置有具有与检测部（14）平行的按压面（18a）的按压部（18）。 按压面（18a）通过朝向检测部（14）被按压而移位，从第一不溶性载体（11）的上侧按压第二不溶性载体（12）和第三不溶性载体（13） 到第一不溶性载体（11）上。 第一装置部件（10）和第二装置部件（20）连接在一起。
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公开(公告)号：US20080160549A1
公开(公告)日：2008-07-03
申请号：US11979849
申请日：2007-11-08
申请人： Takayoshi Oyamada , Junichi Katada
发明人： Takayoshi Oyamada , Junichi Katada
IPC分类号： G01N33/00
CPC分类号： G01N33/558
摘要： An immunochromatography kit including an inorganic silver salt or a silver complex, a reducing agent for silver ions, and a metal colloid label or a metal chalcogenide label. The immunochromatography kit uses an immune reaction of an analyte and an antibody or antigen that can specifically bind to the analyte, and analyzes a signal from a label derived from the immobilized immune complex.
摘要翻译： 包括无机银盐或银络合物，银离子还原剂和金属胶体标记或金属硫族化物标签的免疫色谱试剂盒。 免疫色谱试剂盒使用分析物和可以特异性结合分析物的抗体或抗原的免疫反应，并分析来自固定的免疫复合物的标记的信号。
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公开(公告)号：US08043866B2
公开(公告)日：2011-10-25
申请号：US12285119
申请日：2008-09-29
申请人： Takayoshi Oyamada , Junichi Katada
发明人： Takayoshi Oyamada , Junichi Katada
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S435/81 , Y10S436/808
摘要： A object of the present invention is to provide an immunochromatography method that makes it possible to rapidly detect an ultratrace amount of an analyte that has been impossible to analyze by conventional immunochromatography methods. The present invention provides an immunochromatography method, which comprises developing an analyte and a labeling substance which is modified with a first binding substance against the analyte in a mixed state on a porous carrier and capturing the analyte and the label at a reaction site on the porous carrier having a second binding substance against the analyte or a substance capable of binding to the first binding substance against the analyte, so as to detect the analyte, wherein the labeling substance having an average particle size of 1 μm or more and 20 μm or less is detected.
摘要翻译： 本发明的目的是提供一种免疫色谱法，其可以通过常规的免疫色谱法快速检测不可分析的超分子量的分析物。 本发明提供一种免疫层析方法，其包括在多孔载体上以混合状态将第一结合物质与第一结合物质进行修饰的分析物和标记物质开发，并在多孔载体上的反应位点捕获分析物和标记物 载体，其具有针对分析物的第二结合物质或能够结合到分析物上的第一结合物质的物质，以便检测分析物，其中平均粒径为1μm以上且20μm以下的标记物质 被检测到。
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公开(公告)号：US20080166821A1
公开(公告)日：2008-07-10
申请号：US11979847
申请日：2007-11-08
申请人： Takayoshi Oyamada , Junichi Katada
发明人： Takayoshi Oyamada , Junichi Katada
IPC分类号： G01N33/536
CPC分类号： G01N33/542 , G01N33/558
摘要： An immunochromatography kit including organic silver salt particles, a reducing agent for silver ions, and a metal colloid label or a metal sulfide label. The immunochromatography kit uses an immunoreaction of an analyte and an antibody or antigen that can bind specifically thereto, and analyzes a signal from a label derived from an immune complex.
摘要翻译： 一种免疫色谱试剂盒，包括有机银盐颗粒，银离子还原剂和金属胶体标签或金属硫化物标签。 免疫色谱试剂盒使用分析物和可以特异结合的抗体或抗原的免疫反应，并分析来自免疫复合物的标记的信号。
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公开(公告)号：US08383422B2
公开(公告)日：2013-02-26
申请号：US12471805
申请日：2009-05-26
IPC分类号： G01N33/558
CPC分类号： G01N33/543 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
摘要翻译： 本发明提供一种免疫色谱装置，其包含以下（a）和（b）：（a）第一装置部分，其保持用于显影由分析物形成的复合物的第一不溶性载体和包含标记有 可以结合分析物并捕获分析物和标记物质的第一结合物质，所述反应部分含有可结合分析物的第二结合物质，和（b）保持用于显影的第二不溶性载体的第二装置部分 用于吸收液体的液体和第三不溶性载体，使得第一不溶性载体不与第二不溶性载体和第三不溶性载体接触。
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公开(公告)号：US08999730B2
公开(公告)日：2015-04-07
申请号：US12961140
申请日：2010-12-06
申请人： Takayoshi Oyamada , Junichi Katada , Kenji Narahara , Daisuke Ogata , Tomonori Takeshige , Akihiko Onodera
发明人： Takayoshi Oyamada , Junichi Katada , Kenji Narahara , Daisuke Ogata , Tomonori Takeshige , Akihiko Onodera
IPC分类号： G01N33/58 , G01N33/543 , G01N33/558
CPC分类号： G01N33/54393 , G01N33/558 , G01N33/585
摘要： It is an object of the present invention to provide an immunochromatography method capable of measuring a sample in a low concentration range and a high concentration range by setting the measurable range of the sample much wider than the conventional measurable range. The present invention provides an immunochromatography method, which comprises: spreading a test substance, a first labeling substance modified with a first binding substance that binds to the test substance, and a second labeling substance modified with the first binding substance that binds to the test substance, which are in a mixed state, on an insoluble carrier; and capturing the test substance, the first labeling substance, and/or the second labeling substance at a reaction site on the insoluble carrier having a substance having ability to bind to the first binding substance that binds to the test substance, so as to detect the test substance, wherein the first labeling substance is a labeling substance that causes an amplification reaction, and the second labeling substance is a labeling substance that does not substantially influence on the amplification reaction.
摘要翻译： 本发明的目的是提供一种免疫色谱法，其能够通过将样品的可测量范围设定为比现有的可测量范围宽得多的范围来测量低浓度范围和高浓度范围的样品。 本发明提供了一种免疫色谱法，其包括：扩散测试物质，用与测试物质结合的第一结合物质改性的第一标记物质和与第一结合物质相结合的第二标记物质， 在不溶性载体上处于混合状态; 以及在具有结合到与测试物质结合的第一结合物质的能力的物质的不溶性载体上的反应部位捕获测试物质，第一标记物质和/或第二标记物质，以便检测 测试物质，其中所述第一标记物质是引起扩增反应的标记物质，所述第二标记物质是对扩增反应没有实质影响的标记物质。
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