公开(公告)号：US07135307B2

公开(公告)日：2006-11-14

申请号：US10486265

申请日：2002-08-08

申请人： Ming-Chih Crouthamel ,  Stephen J. Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

发明人： Ming-Chih Crouthamel ,  Stephen J. Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

IPC分类号： C12Q1/37 ,  C12N9/50 ,  A23J1/00

CPC分类号： C12N9/6478 ,  A61K38/00 ,  C07K14/4711 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2333/96472 ,  G01N2500/04

摘要： Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to Aβ peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimers disease, are disclosed.

摘要翻译： 提供Gamma三蛋白酶，一种能够参与淀粉样蛋白前体蛋白（APP）加工成Abeta肽的新型天冬氨酰基类蛋白酶。 伽玛三蛋白酶可能参与阿尔茨海默病的发展和/或发展。 公开了可用于预防或治疗阿尔茨海默病的γ三蛋白酶抑制剂的方法。

公开(公告)号：US20050065076A1

公开(公告)日：2005-03-24

申请号：US10486265

申请日：2002-08-08

申请人： Ming-Chih Crouthamel ,  Stephen Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

发明人： Ming-Chih Crouthamel ,  Stephen Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/37 ,  G01N33/68 ,  C12N1/00

CPC分类号： C12N9/6478 ,  A61K38/00 ,  C07K14/4711 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2333/96472 ,  G01N2500/04

摘要： Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to Aβ peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimers disease, are disclosed.

摘要翻译： 提供Gamma三蛋白酶，一种能够参与淀粉样蛋白前体蛋白（APP）加工成Abeta肽的新型天冬氨酰基类蛋白酶。 伽玛三蛋白酶可能参与阿尔茨海默病的发展和/或发展。 公开了可用于预防或治疗阿尔茨海默病的γ三蛋白酶抑制剂的方法。

公开(公告)号：US20060036077A1

公开(公告)日：2006-02-16

申请号：US11243578

申请日：2005-10-05

申请人： Yueming Li ,  Min Xu ,  Qian Huang ,  Stephen Gardell

发明人： Yueming Li ,  Min Xu ,  Qian Huang ,  Stephen Gardell

IPC分类号： C07K14/47 ,  C12Q1/37

CPC分类号： C07H21/04 ,  C12Q1/37 ,  G01N2500/04 ,  G01N2800/2821

摘要： The present invention features γ-secretase substrates and in vitro assays for measuring γ-secretase activity employing such substrates. The γ-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a β-CTF domain. A “β-CTF domain” is a polypeptide that can be cleaved by γ-secretase and which approximates the C-terminal fragment (amino acids 596-695) of APP produced after cleavage of APP by a β-secretase, or is a functional derivative thereof.

公开(公告)号：US09554128B2

公开(公告)日：2017-01-24

申请号：US14342334

申请日：2012-08-09

申请人： Chih-Wei Hsu ,  Qian Huang ,  Jicheng An ,  Xun Guo ,  Yu-Wen Huang ,  Shaw-Min Lei

发明人： Chih-Wei Hsu ,  Qian Huang ,  Jicheng An ,  Xun Guo ,  Yu-Wen Huang ,  Shaw-Min Lei

IPC分类号： H04N19/117 ,  H04N19/50 ,  H04N19/176 ,  H04N19/14 ,  H04N19/186 ,  H04N19/82 ,  H04N19/86

CPC分类号： H04N19/117 ,  H04N19/14 ,  H04N19/176 ,  H04N19/186 ,  H04N19/50 ,  H04N19/82 ,  H04N19/86

摘要： A method and apparatus for deblocking of reconstructed video are disclosed. In one embodiment, the method divides a block boundary into two sub-boundaries and separates lines or column across the sub-boundaries into two groups. The deblocking filter decision for each group is determined based on the lines or columns in the respective group. In another embodiment, the method divides block edges of blocks in the LCUs into two edge groups, where the first edge group corresponds to horizontal block edges between two LCUs and the second edge group corresponds to remaining block edges not included in the first edge group. The number of lines processed by a vertical filter in the first edge group is less than the number of lines processed by a vertical filter in the second edge group. Accordingly, a system embodying the present invention has reduced storage requirement.

摘要翻译： 公开了一种重构视频解块的方法和装置。 在一个实施例中，该方法将块边界划分为两个子边界，并将跨越子边界的线或列分成两组。 基于相应组中的线或列确定每组的去块滤波器决定。 在另一个实施例中，该方法将LCU中的块的块边缘划分为两个边缘组，其中第一边缘组对应于两个LCU之间的水平块边缘，并且第二边缘组对应于未包括在第一边缘组中的剩余块边缘。 由第一边缘组中的垂直滤波器处理的线数小于由第二边缘组中的垂直滤波器处理的线数。 因此，体现本发明的系统减少了存储要求。

公开(公告)号：US20130145243A1

公开(公告)日：2013-06-06

申请号：US13433740

申请日：2012-03-29

申请人： Qian Huang ,  Li-Juan Xu

发明人： Qian Huang ,  Li-Juan Xu

IPC分类号： G06F17/00

CPC分类号： G06Q10/109 ,  G06Q10/06311

摘要： A task management system including a monitor and a processing unit is provided. The monitor is for displaying a task schedule, which sequentially tabulates multiple time spots and multiple corresponding tasks. The processing unit is for operating an object at a to-be-executed time spot when the object is dragged to the to-be-executed time spot of the task schedule.

摘要翻译： 提供了包括监视器和处理单元的任务管理系统。 显示器用于显示任务计划，其顺序列出多个时间点和多个相应的任务。 处理单元用于在将对象拖动到任务调度的待执行时间点时在待执行的时间点上操作对象。

公开(公告)号：US08370869B2

公开(公告)日：2013-02-05

申请号：US11448114

申请日：2006-06-06

申请人： Seungyup Paek ,  Ana Benitez ,  Shih-Fu Chang ,  Atul Puri ,  Qian Huang ,  Chung-Sheng Li ,  John R. Smith ,  Lawrence Bergman

发明人： Seungyup Paek ,  Ana Benitez ,  Shih-Fu Chang ,  Atul Puri ,  Qian Huang ,  Chung-Sheng Li ,  John R. Smith ,  Lawrence Bergman

IPC分类号： H04H60/32 ,  G06K9/00

CPC分类号： G06K9/00711 ,  G06F17/30858 ,  G06K9/468

摘要： Systems and methods for describing video content establish video description records which include an object set (24), an object hierarchy (26) and entity relation graphs (28). Video objects can include global objects, segment objects and local objects. The video objects are further defined by a number of features organized in classes, which in turn are further defined by a number of feature descriptors (36, 38, and 40). The relationships (44) between and among the objects in the object set (24) are defined by the object hierarchy (26) and entity relation graphs (28). The video description records provide a standard vehicle for describing the content and context of video information for subsequent access and processing by computer applications such as search engines, filters and archive systems.

摘要翻译： 用于描述视频内容的系统和方法建立包括对象集（24），对象层次（26）和实体关系图（28）的视频描述记录。 视频对象可以包括全局对象，段对象和本地对象。 视频对象由类别中组织的多个特征进一步限定，这些特征又由多个特征描述符（36,38和40）进一步限定。 对象集合（24）中的对象之间和之间的关系（44）由对象层次结构（26）和实体关系图（28）定义。 视频描述记录提供用于描述视频信息的内容和上下文的标准车辆，以便随后通过计算机应用（例如搜索引擎，过滤器和归档系统）进行访问和处理。

公开(公告)号：US07970822B2

公开(公告)日：2011-06-28

申请号：US12372052

申请日：2009-02-17

申请人： Ana Belen Benitez ,  Shih-Fu Chang ,  Qian Huang ,  Seungyup Paek ,  Atul Puri

发明人： Ana Belen Benitez ,  Shih-Fu Chang ,  Qian Huang ,  Seungyup Paek ,  Atul Puri

IPC分类号： G06F15/16 ,  G06F12/00

CPC分类号： G06F17/30044 ,  G06F17/3002 ,  G06F17/30038 ,  G06F17/30858 ,  G06F17/30914 ,  G06F17/30958 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and categorize the multimedia content. In this manner, a user who may be interested in locating a specific piece of multimedia content from a database, Internet, or broadcast media, for example, may search for and find the multimedia content. In this regard, the invention provides a system and method that receives multimedia content and separates the multimedia content into separate components which are assigned to multimedia categories, such as image, video, audio, synthetic and text. Within each of the multimedia categories, the multimedia content is classified and descriptions of the multimedia content are generated. The descriptions are then formatted, integrated, using a multimedia integration description scheme, and the multimedia integration description is generated for the multimedia content. The multimedia description is then stored into a database. As a result, a user may query a search engine which then retrieves the multimedia content from the database whose integration description matches the query criteria specified by the user. The search engine can then provide the user a useful search result based on the multimedia integration description.

摘要翻译： 本发明提供一种用于以允许人，软件组件或设备容易地识别，表示，管理，检索和分类多媒体内容的方式来集成多媒体描述的系统和方法。 以这种方式，例如，可能有兴趣从数据库，因特网或广播媒体定位特定的多媒体内容的用户可以搜索和查找多媒体内容。 在这方面，本发明提供了一种接收多媒体内容并将多媒体内容分离成分配给多媒体类别（诸如图像，视频，音频，合成和文本）的组件的系统和方法。 在多媒体类别的每一个内，对多媒体内容进行分类，并且生成多媒体内容的描述。 然后使用多媒体集成描述方案对所述描述进行格式化，集成化，并且为多媒体内容生成多媒体集成描述。 然后将多媒体描述存储到数据库中。 结果，用户可以查询搜索引擎，该搜索引擎然后从整合描述与用户指定的查询标准匹配的数据库中检索多媒体内容。 然后，搜索引擎可以基于多媒体整合描述向用户提供有用的搜索结果。

公开(公告)号：US07843193B2

公开(公告)日：2010-11-30

申请号：US11859020

申请日：2007-09-21

申请人： Qian Huang

发明人： Qian Huang

IPC分类号： G01R33/06

CPC分类号： G01R33/07

摘要： A system and method for determining the magnetic sensitivity of a Hall-effect switch through the use of a variable powered DC electromagnet having a permanent magnet attached to it. In use the electromagnet is placed in contact with a Hall-effect switch component and the DC voltage varied until a detector determines the Hall-effect switch has been triggered. The electromagnet is then moved to be in contact with a probe connected to a Gauss meter to determine the magnetic sensitivity of the Hall-effect switch.

摘要翻译： 一种用于通过使用具有附接到其上的永磁体的可变动力DC电磁铁来确定霍尔效应开关的磁敏感度的系统和方法。 在使用中，电磁体与霍尔效应开关组件接触，直流电压变化，直到检测器确定霍尔效应开关已被触发。 然后将电磁铁移动与与高斯计连接的探头接触，以确定霍尔效应开关的磁敏感度。

公开(公告)号：US20100106722A1

公开(公告)日：2010-04-29

申请号：US12648988

申请日：2009-12-29

申请人： Qian Huang ,  Joern Ostermann ,  Atul Puri ,  Raj Kumar Rajendran

发明人： Qian Huang ,  Joern Ostermann ,  Atul Puri ,  Raj Kumar Rajendran

IPC分类号： G06F17/00 ,  G06F17/30

CPC分类号： G06F17/30017 ,  G06F17/30858 ,  G06F17/30864 ,  H04N1/00209

摘要： A method and system for description of synthetic audiovisual content makes it easier for humans, software components or devices to identify, manage, categorize, search, browse and retrieve such content. For instance, a user may wish to search for specific synthetic audiovisual objects in digital libraries, Internet web sites or broadcast media; such a search is enabled by the invention. Key characteristics of synthetic audiovisual content itself such as the underlying 2d or 3d models and parameters for animation of these models are used to describe it. More precisely, to represent features of synthetic audiovisual content, depending on the description scheme to be used, a number of descriptors are selected and assigned values. The description scheme instantiated with descriptor values is used to generate the description, which is then stored for actual use during query/search. Typically, a user, to search for a needed synthetic audiovisual content initiates a query that is passed on to a search engine that then retrieves the candidate content from one or more databases whose description closely matches the query criteria specified by the user.

摘要翻译： 用于描述合成视听内容的方法和系统使人，软件组件或设备更容易识别，管理，分类，搜索，浏览和检索这些内容。 例如，用户可能希望在数字图书馆，互联网网站或广播媒体中搜索特定的合成音像对象; 通过本发明实现了这种搜索。 合成视听内容本身的关键特征，例如基本的2d或3d模型和这些模型的动画参数用于描述。 更精确地，为了表示合成视听内容的特征，根据要使用的描述方案，选择多个描述符并分配值。 用描述符值实例化的描述方案用于生成描述，然后在查询/搜索期间将其描述为实际使用。 通常，用户搜索所需的合成视听内容启动传递到搜索引擎的查询，该搜索引擎然后从其描述与用户指定的查询标准紧密匹配的一个或多个数据库中检索候选内容。

公开(公告)号：US20070135373A1

公开(公告)日：2007-06-14

申请号：US11602476

申请日：2006-11-20

申请人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

发明人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

IPC分类号： A61K48/00 ,  A61N1/39

CPC分类号： A61K38/191 ,  A61K38/208 ,  A61K48/00 ,  A61K48/0058 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2830/85 ,  C12N2840/203

摘要： A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.

摘要翻译： 用于控制体内热诱导基因表达以提供治疗性多肽的方法。 该方法包括以下步骤：（a）提供包含编码治疗性多肽的多核苷酸的构建体，其中所述多核苷酸可操作地连接于热诱导型启动子; （b）将该构建体施用于在肿瘤处或其附近的部位的温血脊椎动物; 和（c）向肿瘤处或附近的部位施加热量以表达治疗性多肽，由此观察到抗肿瘤活性。