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37 条记录 (耗时 0.021 秒)

    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application
    1.
    发明授权
    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application 失效
    3-苯基异喹啉-1（2H） - 酮衍生物的制备及其治疗应用

    公开(公告)号：US5665733A

    公开(公告)日：1997-09-09

    申请号：US579677

    申请日：1995-12-28

    申请人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    发明人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P25/04 ,  A61P25/28 ,  A61P27/16 ,  A61P43/00 ,  C07D217/24

    CPC分类号： C07D217/24

    摘要： A compound of formula (I) ##STR1## in which X represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group in which case two such alkoxy groups X can be present,Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group,R.sub.1 represents C.sub.1 -C.sub.4 alkyl group, andR represents a hydroxyl group, a methoxy group, an ethoxy group or a group of formula NR.sub.2 R.sub.3 in which R.sub.2 and R.sub.3 each independently represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, or a pharmaceutically acceptable addition salt thereof, processes for their preparation and their therapeutic application.

    摘要翻译： 式（I）化合物其中X表示氢原子，卤素原子，三氟甲基，C1-C3烷基或C1-C3烷氧基，其中两个这样的烷氧基X 可以存在，Y表示氢原子，卤素原子，C1-C3烷基或C1-C3烷氧基，R1表示C1-C4烷基，R表示羟基，甲氧基，乙氧基 或其中R 2和R 3各自独立地表示氢原子或C 1 -C 4烷基的式NR 2 R 3基团或其药学上可接受的加成盐的方法及其治疗应用。

    8-azabicyclo[3.2.1] octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors
    4.
    发明授权
    8-azabicyclo[3.2.1] octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors 失效
    8-氮杂双环[3.2.1]辛烷-3-甲胺衍生物作为D2和D3多巴胺和5HT1A和5HT2血清素受体的配体

    公开(公告)号：US06221879B1

    公开(公告)日：2001-04-24

    申请号：US09529077

    申请日：2000-07-14

    申请人： Benoit Marabout ,  Mireille Sevrin ,  Pascal George ,  Jean-Pierre Merly ,  Daniele De Peretti ,  Jocelyne Roy ,  David Machnik

    发明人： Benoit Marabout ,  Mireille Sevrin ,  Pascal George ,  Jean-Pierre Merly ,  Daniele De Peretti ,  Jocelyne Roy ,  David Machnik

    IPC分类号： A61K3146

    CPC分类号： C07D451/02 ,  A61K31/36 ,  A61K31/46

    摘要： Compounds of general formula (I) in which U represents a group of general formula (A) or (B) in which formulae V represents a hydrogen or halogen atom, a (C1-C3)alkyl group or one or two (C1-C3)alkoxy groups, W and X each represent, respectively, either two oxygen atoms, or an oxygen atom and a CH2 group, or a CH2 group and an oxygen atom, or an oxygen atom and a CO group, n represents the number 0 or 1, R represents either a propyl group when U represents a group of general formula (A), or a hydrogen atom or a (C1-C3)alkyl group when U represents a group of general formula (B), Y represents one or more atoms or groups chosen from the following: hydrogen, halogen, (C1-C3)alkyl and (C1-C3)alkoxy, Z represents two hydrogen atoms or an oxygen atom.

    摘要翻译： 其中U表示通式（A）或（B）的基团的通式（I）的化合物，其中式V表示氢或卤素原子，（C1-C3）烷基或一个或两个（C1-C3 ）烷氧基，W和X分别表示两个氧原子，或氧原子和CH2基团，或CH2基团和氧原子，或氧原子和CO基团，n表示数字0或 1，当U表示通式（A）的基团时，当U表示通式（A）的基团时，R表示丙基，或者当U表示通式（B）的基团时，R表示氢原子或（C1-C3）烷基），Y表示一个或多个 原子或基团：氢，卤素，（C1-C3）烷基和（C1-C3）烷氧基，Z表示两个氢原子或氧原子。

    N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy
    5.
    发明授权
    N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy 失效
    N- [苯基（哌啶-2-基）甲基]苯甲酰胺衍生物，其制备及其在治疗中的用途

    公开(公告)号：US07951821B2

    公开(公告)日：2011-05-31

    申请号：US11680782

    申请日：2007-03-01

    申请人： Gihad Dargazanli ,  Genevieve Estenne-Bouhtou ,  Benoit Marabout ,  Pierre Roger ,  Mireille Sevrin

    发明人： Gihad Dargazanli ,  Genevieve Estenne-Bouhtou ,  Benoit Marabout ,  Pierre Roger ,  Mireille Sevrin

    IPC分类号： A61K31/445

    CPC分类号： C07D211/26

    摘要： This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

    摘要翻译： 本发明公开了一种通式（I）的化合物，其中R 1表示氢原子或任选取代的烷基，或环烷基烷基，或任选取代的苯基烷基或烯基，X表示氢 原子或一个或多个选自卤素原子和三氟甲基，烷基和烷氧基的取代基，R 2表示一个或多个选自卤素原子，任选取代的烷氧基和任选取代的氨基的取代基。 本发明的化合物表现出治疗效用。