利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.035 秒)

    3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments
    4.
    发明授权
    3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments 有权
    3-杂芳基-3,5-二氢-4-氧代-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺衍生物，其药物的制备和用途

    公开(公告)号：US07235554B2

    公开(公告)日：2007-06-26

    申请号：US10509695

    申请日：2003-04-02

    申请人： Jacques Froissant ,  Benoît Marabout ,  Frank Marguet ,  Frédéric Puech

    发明人： Jacques Froissant ,  Benoît Marabout ,  Frank Marguet ,  Frédéric Puech

    IPC分类号： C07D487/04 ,  A61K31/5025

    CPC分类号： C07D209/42 ,  C07D487/04

    摘要： The invention provides compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each independently of one another represent a hydrogen atom or a (C1-C4)alkyl group, or else R2 and R3, together with the nitrogen atom bearing them, form a pyrrolidinyl, piperidinyl, morpholinyl or 4-(C1-C4)alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type which may carry one or more halogen atoms and/or one or more (C1-C4)alkyl and/or (C1-C4)alkoxy groups; in the form of bases, addition salts with acids, solvates or hydrates; the pharmaceutical compositions comprising them, processes for preparing them, and synthesis intermediates.

    摘要翻译： 本发明提供通式（I）的化合物，其中X表示氢或卤素原子; R 1表示氢原子或（C 1 -C 4 -C 4）烷基; R 2和R 3各自独立地表示氢原子或（C 1 -C 4）烷基， ）烷基，或者R 2和R 3 3与带有它们的氮原子一起形成吡咯烷基，哌啶基，吗啉基或4-（C 1 C 4 -C 4烷基哌嗪基; 并且Het表示可携带一个或多个卤素原子和/或一个或多个（C 1 -C 4）烷基的吡啶基，喹啉基，异喹啉基，嘧啶基，吡嗪基或哒嗪基的杂芳族基团， （C 1 -C 4）烷基和/或（C 1 -C 4 -C 4）烷氧基; 碱的形式，与酸，溶剂合物或水合物的加成盐; 包含它们的药物组合物，其制备方法和合成中间体。

    3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use
    5.
    发明授权
    3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use 有权
    3-杂芳基-3,5-二氢-4-氧代-4H-哒嗪并[4,5-b]吲哚-1-甲酰胺衍生物的制备和治疗用途

    公开(公告)号：US07109194B2

    公开(公告)日：2006-09-19

    申请号：US10499725

    申请日：2002-11-20

    申请人： Philippe Burnier ,  Jacques Froissant ,  Benoît Marabout ,  Frank Marguet ,  Frédéric Puech

    发明人： Philippe Burnier ,  Jacques Froissant ,  Benoît Marabout ,  Frank Marguet ,  Frédéric Puech

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D209/04 ,  A61P25/22 ,  A61P25/02

    CPC分类号： C07D487/04 ,  C07D209/42

    摘要： The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1–C4)alkyl group; R2 and R3, represent each, independently of each other, a hydrogen atom or a (C1–C4)alkyl group, or R2 and R3 form, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C1–C4)alkyl, (C1–C4)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates

    摘要翻译： 本发明涉及通式（I）的化合物，其中：X表示氢或卤素原子; R 1表示氢原子或（C 1 -C 4 -C 4）烷基; R 2和R 3各自独立地表示氢原子或（C 1 -C 4）烷基， 或者R 2和R 3形式，其中带有它们的原子，吡咯烷基，哌啶基，吗啉基或4-烷基哌嗪基; 并且Het表示吡啶基，1-氧化吡啶基，喹啉基，异喹啉基，嘧啶基，吡嗪基，哒嗪基类的杂芳族基团，杂芳基可以表示一个或多个卤素原子和/或一个或多个（C 1 H 3） -C 1-4烷基，（C 1 -C 4 -C 4）烷氧基; 以碱的形式，与酸，溶剂化物或水合物的加成盐。 本发明还涉及含有其的药物组合物，其制备方法和合成中间体

    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application
    6.
    发明授权
    3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application 失效
    3-苯基异喹啉-1（2H） - 酮衍生物的制备及其治疗应用

    公开(公告)号：US5665733A

    公开(公告)日：1997-09-09

    申请号：US579677

    申请日：1995-12-28

    申请人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    发明人： Mireille Sevrin ,  Benoit Marabout ,  Jacques Froissant ,  Catherine Guinot

    IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P25/04 ,  A61P25/28 ,  A61P27/16 ,  A61P43/00 ,  C07D217/24

    CPC分类号： C07D217/24

    摘要： A compound of formula (I) ##STR1## in which X represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group in which case two such alkoxy groups X can be present,Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group,R.sub.1 represents C.sub.1 -C.sub.4 alkyl group, andR represents a hydroxyl group, a methoxy group, an ethoxy group or a group of formula NR.sub.2 R.sub.3 in which R.sub.2 and R.sub.3 each independently represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, or a pharmaceutically acceptable addition salt thereof, processes for their preparation and their therapeutic application.

    摘要翻译： 式（I）化合物其中X表示氢原子，卤素原子，三氟甲基，C1-C3烷基或C1-C3烷氧基，其中两个这样的烷氧基X 可以存在，Y表示氢原子，卤素原子，C1-C3烷基或C1-C3烷氧基，R1表示C1-C4烷基，R表示羟基，甲氧基，乙氧基 或其中R 2和R 3各自独立地表示氢原子或C 1 -C 4烷基的式NR 2 R 3基团或其药学上可接受的加成盐的方法及其治疗应用。