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1.发明申请Composition and/or method for preventing onset and/or recurrence of cardiovascular events 有权用于预防心血管事件发作和/或复发的组合物和/或方法公开(公告)号：US20070021504A1
公开(公告)日：2007-01-25
申请号：US11481956
申请日：2006-07-07
申请人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Yuichi Ishikawa , Shinichi Oikawa , Jun Sasaki , Hitoshi Hishida , Hiroshige Itakura , Toru Kita , Akira Kitabatake , Noriaki Nakaya , Toshiie Sakata , Kazuyuki Shimada , Kunio Shirato
发明人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Yuichi Ishikawa , Shinichi Oikawa , Jun Sasaki , Hitoshi Hishida , Hiroshige Itakura , Toru Kita , Akira Kitabatake , Noriaki Nakaya , Toshiie Sakata , Kazuyuki Shimada , Kunio Shirato
IPC分类号： A61K31/23
CPC分类号： A61K31/202 , A61K9/0053 , A61K9/48 , A61K31/232
摘要： Provided are composition and/or methods useful in preventing onset and/or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.
摘要翻译： 提供用于预防心血管事件的发作和/或复发的组合物和/或方法，特别是在已经在心血管血管成形术后不稳定时期或在用HMG-CoA RI治疗的高脂血症患者中的患者中。
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2.发明授权公开(公告)号：US08367725B2
公开(公告)日：2013-02-05
申请号：US11481956
申请日：2006-07-07
申请人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Yuichi Ishikawa , Shinichi Oikawa , Jun Sasaki , Hitoshi Hishida , Hiroshige Itakura , Toru Kita , Akira Kitabatake , Noriaki Nakaya , Toshiie Sakata , Kazuyuki Shimada , Kunio Shirato
发明人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Yuichi Ishikawa , Shinichi Oikawa , Jun Sasaki , Hitoshi Hishida , Hiroshige Itakura , Toru Kita , Akira Kitabatake , Noriaki Nakaya , Toshiie Sakata , Kazuyuki Shimada , Kunio Shirato
IPC分类号： A61K31/232 , A61P9/10
CPC分类号： A61K31/202 , A61K9/0053 , A61K9/48 , A61K31/232
摘要： Provided are composition and/or methods useful in preventing onset and/or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.
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3.发明申请公开(公告)号：US20110118350A1
公开(公告)日：2011-05-19
申请号：US12993715
申请日：2009-05-20
申请人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Hiroshige Itakura
发明人： Mitsuhiro Yokoyama , Hideki Origasa , Masunori Matsuzaki , Yuji Matsuzawa , Yasushi Saito , Hiroshige Itakura
IPC分类号： A61K31/232 , C07C69/587 , G01N33/92 , A61P9/00 , A61P3/00 , A61P3/06
CPC分类号： A61K31/232 , A61K45/06 , A61K2300/00
摘要： Provided is a pharmaceutical composition for reducing the risk in a patient at high risk for occurrence and/or recurrence of a cardiovascular event by administering the composition to the patient with a high ratio of oleic acid to stearic acid in plasma. The pharmaceutical composition contains ethyl icosapentate as its effective component. The composition is expected to reduce the risk in the patient at high risk for occurrence and/or recurrence of a cardiovascular event, and particularly to have a preventive effect on occurrence and/or recurrence of a cardiovascular event in the patient with a high ratio of oleic acid to stearic acid in plasma.
摘要翻译： 本发明提供一种药物组合物，其用于通过将血浆中具有高比例的油酸与硬脂酸的组合物给予患者来降低心血管事件发生和/或复发的高风险患者的风险。 药物组合物含有二十碳五烯酸乙酯作为其有效成分。 预期该组合物将降低患有心血管事件发生和/或复发的高风险的患者的风险，特别是对具有高比例的患者的心血管事件的发生和/或复发具有预防作用 油酸对血浆中的硬脂酸。
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公开(公告)号：US20090105340A1
公开(公告)日：2009-04-23
申请号：US12343974
申请日：2008-12-24
CPC分类号： A61K31/232
摘要： By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.
摘要翻译： 通过使用用于预防脑卒中发作和/或复发的组合物，该组合物含有二十碳五烯酸乙酯作为其有效成分，可预防中风的发作和/或复发，特别是高脂血症患者中风的发作和/或复发 已经用HMG-CoA RI治疗，特别是中风发作6个月以上患者的中风再次发作。
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公开(公告)号：US07498359B2
公开(公告)日：2009-03-03
申请号：US11486091
申请日：2006-07-14
IPC分类号： A61K31/215 , A61K31/33 , A61K31/335
CPC分类号： A61K31/232
摘要： By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.
摘要翻译： 通过使用用于预防脑卒中发作和/或复发的组合物，该组合物含有二十碳五烯酸乙酯作为其有效成分，可预防中风的发作和/或复发，特别是高脂血症患者中风的发作和/或复发 已经用HMG-CoA RI治疗，特别是中风发作6个月以上患者的中风再次发作。
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公开(公告)号：US20070185198A1
公开(公告)日：2007-08-09
申请号：US11486091
申请日：2006-07-14
IPC分类号： A61K31/22
CPC分类号： A61K31/232
摘要： By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.
摘要翻译： 通过使用用于预防脑卒中发作和/或复发的组合物，该组合物含有二十碳五烯酸乙酯作为其有效成分，可预防中风的发作和/或复发，特别是高脂血症患者中风的发作和/或复发 已经用HMG-CoA RI治疗，特别是中风发作6个月以上患者的中风再次发作。
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公开(公告)号：US09233093B2
公开(公告)日：2016-01-12
申请号：US13558590
申请日：2012-07-26
IPC分类号： A61K31/22 , A61K31/232
CPC分类号： A61K31/232
摘要： By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.
摘要翻译： 通过使用用于预防脑卒中发作和/或复发的组合物，该组合物含有二十碳五烯酸乙酯作为其有效成分，可预防中风的发作和/或复发，特别是高脂血症患者中风的发作和/或复发 已经用HMG-CoA RI治疗，特别是中风发作6个月以上患者的中风再次发作。
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公开(公告)号：US08258183B2
公开(公告)日：2012-09-04
申请号：US12852558
申请日：2010-08-09
CPC分类号： A61K31/232
摘要： By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.
摘要翻译： 通过使用用于预防脑卒中发作和/或复发的组合物，该组合物含有二十碳五烯酸乙酯作为其有效成分，可预防中风的发作和/或复发，特别是高脂血症患者中风的发作和/或复发 已经用HMG-CoA RI治疗，特别是中风发作6个月以上患者的中风再次发作。
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9.发明申请COMPOSITION FOR PREVENTING THE OCCURRENCE OF CARDIOVASCULAR EVENT IN MULTIPLE RISK PATIENT 有权用于预防多发性风险患者心血管事件发生的组合物公开(公告)号：US20090156675A1
公开(公告)日：2009-06-18
申请号：US12302790
申请日：2007-05-31
IPC分类号： A61K31/202 , A61P9/00
CPC分类号： A61K31/22 , A61K31/202 , A61K31/225 , A61K31/232 , A61K31/351 , A61K31/366 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
摘要翻译： 公开了一种组合物，其可用于预防心血管事件的发生，特别是预期对高胆固醇血症患者发生的心血管事件显示预防效果的组合物，尽管为患者提供了HMG-CoA RI或 心血管事件发生在多重危险患者身上。
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10.发明授权公开(公告)号：US08802718B2
公开(公告)日：2014-08-12
申请号：US13603911
申请日：2012-09-05
IPC分类号： A61K31/232 , A61K31/40 , A61K31/366 , A61K31/225 , A61K31/202
CPC分类号： A61K31/22 , A61K31/202 , A61K31/225 , A61K31/232 , A61K31/351 , A61K31/366 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
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