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17 条记录 (耗时 0.025 秒)

    Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same
    6.
    发明授权
    Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same 失效
    新的2'-脱氧-5-取代的尿苷衍生物，其制备方法和含有它们的抗肿瘤剂

    公开(公告)号：US4886877A

    公开(公告)日：1989-12-12

    申请号：US163237

    申请日：1988-02-26

    申请人： Setsuro Fujii ,  Jun-ichi Yamashita ,  Hiroshi Matsumoto ,  Setsuo Takeda ,  Tadafumi Terada ,  Mitsugi Yasumoto ,  Norio Unemi

    发明人： Setsuro Fujii ,  Jun-ichi Yamashita ,  Hiroshi Matsumoto ,  Setsuo Takeda ,  Tadafumi Terada ,  Mitsugi Yasumoto ,  Norio Unemi

    IPC分类号： C07D405/04 ,  C07H19/06

    CPC分类号： C07H19/06

    摘要： Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.

    摘要翻译： 由通式表示的新型2'-脱氧-5-取代的尿苷衍生物，其中R1是氢原子，苯甲酰基或四氢呋喃基; R2是氟原子或三氟甲基; R 3和R 4中的任一个为氢原子，另一个为碳原子数1〜10的烷基，碳原子数为2〜6的烯基，作为取代基的苄基，选自 卤原子，碳原子数为1〜4的烷基，碳原子数为1〜4的烷氧基，硝基，碳原子数为1〜3的烷基，具有一个或两个苯基作为取代基。 新型2'-脱氧-5-取代尿苷衍生物具有优异的抗肿瘤活性，毒性低，因此可用作抗肿瘤剂。

    2'-deoxy-5-substituted uridine derivatives
    8.
    发明授权
    2'-deoxy-5-substituted uridine derivatives 失效
    2'-脱氧-5-取代的尿苷衍生物

    公开(公告)号：US5250673A

    公开(公告)日：1993-10-05

    申请号：US422721

    申请日：1989-10-17

    申请人： Setsuro Fujii ,  Jun-ichi Yamashita ,  Hiroshi Matsumoto ,  Setsuo Takeda ,  Tadafumi Terada ,  Mitsugi Yasumoto ,  Norio Unemi

    发明人： Setsuro Fujii ,  Jun-ichi Yamashita ,  Hiroshi Matsumoto ,  Setsuo Takeda ,  Tadafumi Terada ,  Mitsugi Yasumoto ,  Norio Unemi

    IPC分类号： C07H19/06 ,  C07H19/073

    CPC分类号： C07H19/06

    摘要： Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.

    摘要翻译： 由通式表示的新型2'-脱氧-5-取代的尿苷衍生物，其中R1是氢原子，苯甲酰基或四氢呋喃基; R2是氟原子或三氟甲基; R 3和R 4中的任一个为氢原子，另一个为碳原子数1〜10的烷基，碳原子数为2〜6的烯基，作为取代基的苄基，选自 卤原子，碳原子数为1〜4的烷基，碳原子数为1〜4的烷氧基，硝基，碳原子数为1〜3的烷基，具有一个或两个苯基作为取代基。 新型2'-脱氧-5-取代尿苷衍生物具有优异的抗肿瘤活性，毒性低，因此可用作抗肿瘤剂。

    Anti-cancer composition for delivering 5-fluorouracil
    9.
    发明授权
    Anti-cancer composition for delivering 5-fluorouracil 失效
    用于递送5-氟尿嘧啶的抗癌组合物

    公开(公告)号：US4719213A

    公开(公告)日：1988-01-12

    申请号：US901202

    申请日：1986-08-28

    申请人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

    发明人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

    IPC分类号： A61K31/505 ,  C07D239/54 ,  C07D239/553

    CPC分类号： C07D239/553 ,  A61K31/505

    摘要： An anti-cancer composition for delivering a 5-fluorouracil to cancer tissues in a warm-blooded animal, wherein the cancer is a cancer sensitive to 5-fluorouracil. The composition comprises uracil or a pharmaceutically acceptable salt thereof, and a 5-fluorouracil pro drug selected from the group consisting of 1, 3-bis (2-tetrahydrofuryl)-5-fluorouracil and 3-(2-tetrahydrofuryl)-5-fluorouracil in a small amount of about 0.1 to less than 0.1 mole per mole of uracil or salt thereof.

    摘要翻译： 一种用于将5-氟尿嘧啶递送至温血动物的癌症组织的抗癌组合物，其中所述癌症是对5-氟尿嘧啶敏感的癌症。 该组合物包含尿嘧啶或其药学上可接受的盐，和5-氟尿嘧啶前药，其选自1,3-双（2-四氢呋喃基）-5-氟尿嘧啶和3-（2-四氢呋喃基）-5-氟尿嘧啶 其量为每摩尔尿嘧啶或其盐约0.1至小于0.1摩尔的少量。