公开(公告)号：US07660626B2

公开(公告)日：2010-02-09

申请号：US11195364

申请日：2005-08-02

申请人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

公开(公告)号：US20100030128A1

公开(公告)日：2010-02-04

申请号：US12065851

申请日：2006-09-01

申请人： Kazuma Mitsuguchi ,  Mitsugu Yamauchi ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Kazuma Mitsuguchi ,  Mitsugu Yamauchi ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/303

摘要： The transport efficiency of a drug using an iontophoresis device is increased using a negative pressure device.The iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering drug by iontophoresis. Each of the working electrode assembly and the non-working electrode assembly includes an adhesive surface configured to adhere to a biological interface. A DC electric power source is connected to the working electrode assembly and the non-working electrode assembly. The iontophoresis device further includes a negative pressure device integral with at least one of the working electrode assembly and the non-working electrode assembly and configured to maintain a negative pressure between the at least one of the working electrode assembly and the non-working electrode assembly and the biological interface.

摘要翻译： 使用离子渗透装置的药物的输送效率使用负压装置增加。 离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件。 工作电极组件和非工作电极组件中的每一个包括被配置为粘附到生物界面的粘合表面。 直流电源连接到工作电极组件和非工作电极组件。 离子电渗装置还包括与至少一个工作电极组件和非工作电极组件成一体的负压装置，并且构造成在工作电极组件和非工作电极组件中的至少一个之间保持负压 和生物界面。

公开(公告)号：US20100016781A1

公开(公告)日：2010-01-21

申请号：US11991234

申请日：2006-08-29

申请人： Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/303 ,  A61N1/0444 ,  A61N1/08

摘要： An iontophoresis device including an electric power source. A first electrode assembly is electrically coupled to the electric power source to transdermally administer an ionic drug to an organism via iontophoresis while a second electrode assembly is electrically coupled to the electric power source as a counter electrode to the first electrode assembly. A sensor may be positioned proximate an internal or external portion of the organism and operable to determine information used to select and deliver the ionic drug to the organism.

摘要翻译： 一种离子电渗疗法装置，包括电源。 第一电极组件电耦合到电源，以通过离子电渗将离子药物透皮施用于生物体，而第二电极组件作为与第一电极组件的对电极电耦合到电源。 传感器可以定位在生物体的内部或外部附近，并且可操作以确定用于选择并将离子药物递送到生物体的信息。

公开(公告)号：US20090299264A1

公开(公告)日：2009-12-03

申请号：US11992671

申请日：2006-09-28

申请人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/0444

摘要： An iontophoresis device capable of stably holding a drug for a long time period and of transdermally administering the drug at a high transport number during use. The iontophoresis device includes a drug holding portion to store the ionic drug in a dry state and at least an aqueous medium holding portion to store an aqueous medium. The drug holding portion exhibiting ion conductivity in response to a needle inserted into the aqueous medium holding portion from outside the electrode assembly such that the drug holding portion is supplied with the aqueous medium during use and the ionic drug dissolves in the aqueous medium.

摘要翻译： 一种能够长时间稳定地保持药物并且在使用期间以高转运数量经皮给药的离子电渗疗装置。 离子电渗装置包括药物保持部分，用于将离子药物储存在干燥状态，并且至少含有水性介质保持部分以存储水性介质。 药物保持部分响应于从电极组件外部插入到水性介质保持部分中的针而显示离子传导性，使得在使用期间向药物保持部分供给水性介质，并且离子药物溶解在水性介质中。

公开(公告)号：US20070135754A1

公开(公告)日：2007-06-14

申请号：US11537459

申请日：2006-09-29

申请人： Hidero Akiyama ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Akihiko Matsumura

发明人： Hidero Akiyama ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/044 ,  A61N1/0444

摘要： An electrode assembly for iontophoresis may enable the administration of a non-ionic active agent ionized, or an active agent that is substantially insoluble in water, by iontophoresis. An electrode assembly used for iontophoresis may hold an active agent enclosed in an ionic nanoparticle.

摘要翻译： 用于离子电渗疗法的电极组件可以通过离子电渗法施用电离的非离子活性剂或基本上不溶于水的活性剂。 用于离子电渗疗法的电极组件可以包含封闭在离子纳米颗粒中的活性剂。

公开(公告)号：US20060173401A1

公开(公告)日：2006-08-03

申请号：US11195364

申请日：2005-08-02

申请人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

公开(公告)号：US20090299265A1

公开(公告)日：2009-12-03

申请号：US11992672

申请日：2006-10-02

申请人： Akihiko Tanioka ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Akihiko Tanioka ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.

摘要翻译： 一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分， 保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子， 第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换 膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够 在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。

公开(公告)号：US20090221951A1

公开(公告)日：2009-09-03

申请号：US12066362

申请日：2006-09-13

申请人： Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/30

摘要： A drug may be administered in accordance with a daily living pattern of a patient and/or a circadian rhythm of the drug.An iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering a drug by iontophoresis and an electric power source connected to the working electrode assembly and the non-working electrode assembly. Current control circuitry programmably controls a current that flows to each of the electrode assemblies according to a set pattern, and the drug is released based at least in part on the current.

摘要翻译： 可以根据患者的日常生活方式和/或药物的昼夜节律来施用药物。 离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件和连接到工作电极组件和非工作电极组件的电源。 电流控制电路可编程地控制根据设定模式流向每个电极组件的电流，并且至少部分地基于电流释放药物。

公开(公告)号：US20070071807A1

公开(公告)日：2007-03-29

申请号：US11536194

申请日：2006-09-28

申请人： Hidero Akiyama ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Akihiko Matsumura

发明人： Hidero Akiyama ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Akihiko Matsumura

IPC分类号： A61N1/00 ,  A61K9/48

CPC分类号： A61K9/0009 ,  A61K9/0097 ,  A61K9/48

摘要： A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.

摘要翻译： 胶囊型药物释放装置能够自由地控制药物的释放和停止，并且不会引起胃，肠等的内容物的反流，也不会堵塞内容物。 胶囊型药物释放装置可以包括：胶囊型壳体; 设置在所述壳体的表面上的阳离子交换膜; 药液保持部，其配置在所述壳体内部和所述阳离子交换膜的内侧; 阴离子交换膜，其设置在药液保持部的内侧; 设置在阴离子交换膜的内侧的电解液保持部， 设置在所述电解液保持部的内侧的电极; 连接到电极的电源; 控制部，其能够控制从所述电源向所述电极的通电; 以及使得所述控制部分从生物体的外部接收信号的收发器部分。

公开(公告)号：US20070066930A1

公开(公告)日：2007-03-22

申请号：US11471973

申请日：2006-06-20

申请人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

IPC分类号： A61N1/30 ,  A61L33/00 ,  B32B18/00

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.

摘要翻译： 离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。 离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。