公开(公告)号：US20220387628A1

公开(公告)日：2022-12-08

申请号：US17618779

申请日：2020-06-24

Applicant: ModernaTX, Inc.

Inventor： Ruchi JAIN ,  David REID ,  Vladimir PRESNYAK ,  Alicia BICKNELL ,  Caroline KÖHRER

IPC: A61K48/00

Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide desirable regulation of mRNA localization, stability, and/or translation to yield increased mRNA expression and activity of an encoded polypeptide.

公开(公告)号：US20220251577A1

公开(公告)日：2022-08-11

申请号：US17618776

申请日：2020-06-24

Applicant: ModernaTX, Inc.

Inventor： Alicia BICKNELL ,  Vladimir PRESNYAK ,  Caroline KÖHRER

IPC: C12N15/67 ,  A61K31/7105

Abstract: The present disclosure provides messenger RNAs (mRNAs) with alterations which provide increased endonuclease resistance to the mRNA and methods and uses thereof.