公开(公告)号：US20210163928A1

公开(公告)日：2021-06-03

申请号：US17041332

申请日：2019-04-11

Applicant: ModernaTX, Inc.

Inventor： David REID ,  Caroline KÖHRER ,  Ruchi JAIN ,  Melissa J. MOORE ,  Scott DONOVAN ,  Aaron LARSEN ,  Vladimir PRESNYAK

IPC: C12N15/11 ,  A61K48/00 ,  C12Q1/6897

Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, in particular C-rich or CG-rich elements, which provide a desired translational regulatory activity to the mRNA.

公开(公告)号：US20220387628A1

公开(公告)日：2022-12-08

申请号：US17618779

申请日：2020-06-24

Applicant: ModernaTX, Inc.

Inventor： Ruchi JAIN ,  David REID ,  Vladimir PRESNYAK ,  Alicia BICKNELL ,  Caroline KÖHRER

IPC: A61K48/00

Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide desirable regulation of mRNA localization, stability, and/or translation to yield increased mRNA expression and activity of an encoded polypeptide.