公开(公告)号：US20220126244A1

公开(公告)日：2022-04-28

申请号：US17424799

申请日：2020-01-31

Applicant: ModernaTX, Inc.

Inventor： Stephanie KIRBY ,  Benjamin GELDHOF ,  Kaelyn VIK ,  Brie SKINNER

IPC: B01F25/10 ,  B01F33/81 ,  B01F33/30

Abstract: A vortex mixer may have a vortex mixing chamber having a first wall, a second wall, and a side wall connecting the first wall and the second wall. At least two inlet ports may be configured along the side wall, each inlet port having an inlet channel connected thereto. The at least two inlet ports may be approximately equally spaced around the vortex mixing chamber and configured tangentially to the vortex mixing chamber. An exit port may have an exit channel connected thereto. The exit port may be configured at a radial center of the second wall, and the exit channel may extend from the exit port and away from the vortex mixing chamber.

公开(公告)号：US20250049728A1

公开(公告)日：2025-02-13

申请号：US18720092

申请日：2022-12-15

Applicant: ModernaTX, Inc.

Inventor： Chang TIAN ,  Michael H. SMITH ,  Benjamin GELDHOF

IPC: A61K9/51

Abstract: The present disclosure provides processes for controlled high-throughput preparation of lipid nanoparticle with defined parameters, e.g., processes for preparing lipid nanoparticles (LNPs), using a T-Mixer (e.g., a T-Mixer as described herein). The present disclosure also provides lipid nanoparticle solutions (LNP solutions) and lipid nanoparticles (LNPs) being prepared by the processes.