公开(公告)号：US20230285297A1

公开(公告)日：2023-09-14

申请号：US17792554

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Michael H. SMITH ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K47/24 ,  A61K47/28 ,  A61K31/7105 ,  A61K47/26 ,  A61K47/12

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/1278 ,  A61K31/7105 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and LNP formulations produced by using such methods. The present disclosure further provides therapeutic and diagnostic uses related to the produced LNP formulations.

公开(公告)号：US20250049728A1

公开(公告)日：2025-02-13

申请号：US18720092

申请日：2022-12-15

Applicant: ModernaTX, Inc.

Inventor： Chang TIAN ,  Michael H. SMITH ,  Benjamin GELDHOF

IPC: A61K9/51

Abstract: The present disclosure provides processes for controlled high-throughput preparation of lipid nanoparticle with defined parameters, e.g., processes for preparing lipid nanoparticles (LNPs), using a T-Mixer (e.g., a T-Mixer as described herein). The present disclosure also provides lipid nanoparticle solutions (LNP solutions) and lipid nanoparticles (LNPs) being prepared by the processes.

公开(公告)号：US20230277457A1

公开(公告)日：2023-09-07

申请号：US18040745

申请日：2021-08-06

Applicant: ModernaTX, Inc.

Inventor： Richard Paul SHEPARD ,  Michael H. SMITH ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K9/08

CPC classification number: A61K9/1277 ,  A61K9/1278 ,  A61K9/08 ,  A61K9/1271

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.