公开(公告)号：US20230285297A1

公开(公告)日：2023-09-14

申请号：US17792554

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Michael H. SMITH ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K47/24 ,  A61K47/28 ,  A61K31/7105 ,  A61K47/26 ,  A61K47/12

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/1278 ,  A61K31/7105 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and LNP formulations produced by using such methods. The present disclosure further provides therapeutic and diagnostic uses related to the produced LNP formulations.

公开(公告)号：US20220126244A1

公开(公告)日：2022-04-28

申请号：US17424799

申请日：2020-01-31

Applicant: ModernaTX, Inc.

Inventor： Stephanie KIRBY ,  Benjamin GELDHOF ,  Kaelyn VIK ,  Brie SKINNER

IPC: B01F25/10 ,  B01F33/81 ,  B01F33/30

Abstract: A vortex mixer may have a vortex mixing chamber having a first wall, a second wall, and a side wall connecting the first wall and the second wall. At least two inlet ports may be configured along the side wall, each inlet port having an inlet channel connected thereto. The at least two inlet ports may be approximately equally spaced around the vortex mixing chamber and configured tangentially to the vortex mixing chamber. An exit port may have an exit channel connected thereto. The exit port may be configured at a radial center of the second wall, and the exit channel may extend from the exit port and away from the vortex mixing chamber.

公开(公告)号：US20230277457A1

公开(公告)日：2023-09-07

申请号：US18040745

申请日：2021-08-06

Applicant: ModernaTX, Inc.

Inventor： Richard Paul SHEPARD ,  Michael H. SMITH ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K9/08

CPC classification number: A61K9/1277 ,  A61K9/1278 ,  A61K9/08 ,  A61K9/1271

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.

公开(公告)号：US20220062175A1

公开(公告)日：2022-03-03

申请号：US17424780

申请日：2020-01-31

Applicant: ModernaTX, Inc.

Inventor： Mike SMITH ,  Allen HORHOTA ,  Jason AUER ,  Brie SKINNER

IPC: A61K9/127 ,  A61K48/00 ,  A61K9/51

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.