公开(公告)号：US20190248864A1

公开(公告)日：2019-08-15

申请号：US16398498

申请日：2019-04-30

Applicant: ModernaTX, Inc.

Inventor： Jeff Lynn ELLSWORTH ,  Joseph Beene BOLEN ,  Francine Marie GREGOIRE ,  Justin GUILD

IPC: C07K14/705

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).

公开(公告)号：US20180214579A1

公开(公告)日：2018-08-02

申请号：US15936032

申请日：2018-03-26

Applicant: ModernaTX, Inc.

Inventor： Örn ALMARSSON ,  Noubar B. AFEYAN ,  Joseph Beene BOLEN ,  Staci SABNIS

IPC: A61K48/00 ,  A61K9/00 ,  A61K31/4172 ,  A61K31/405 ,  A61K31/401 ,  A61K31/198 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K38/00

Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.

公开(公告)号：US20210269506A1

公开(公告)日：2021-09-02

申请号：US17026583

申请日：2020-09-21

Applicant: ModernaTX, Inc.

Inventor： Joseph Beene BOLEN ,  Joshua P. FREDERICK

IPC: C07K14/705 ,  A61K48/00 ,  A61K31/7115

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.