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公开(公告)号：US20220273766A1
公开(公告)日：2022-09-01
申请号：US17528588
申请日：2021-11-17
申请人： ModernaTX, Inc.
IPC分类号： A61K38/19 , A61K31/395 , A61K31/7088 , A61K31/7115 , A61K38/13 , A61K38/28 , C07K14/62 , C07K14/685 , A61K31/495 , A61K39/395 , A61K48/00
摘要： Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
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公开(公告)号：US20180214579A1
公开(公告)日：2018-08-02
申请号：US15936032
申请日：2018-03-26
申请人： ModernaTX, Inc.
IPC分类号： A61K48/00 , A61K9/00 , A61K31/4172 , A61K31/405 , A61K31/401 , A61K31/198 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/0019 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K38/00
摘要： The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
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公开(公告)号：US20180000910A1
公开(公告)日：2018-01-04
申请号：US15429532
申请日：2017-02-10
申请人： ModernaTX, Inc.
发明人： Tirtha CHAKRABORTY , Stephane BANCEL , Stephen G. HOGE , Atanu ROY , Antonin de FOUGEROLLES , Noubar B. AFEYAN
摘要： The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
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公开(公告)号：US20220395562A1
公开(公告)日：2022-12-15
申请号：US17127435
申请日：2020-12-18
申请人： ModernaTX, Inc.
发明人： Tirtha CHAKRABORTY , Stephane BANCEL , Stephen G. HOGE , Atanu ROY , Antonin DE FOUGEROLLES , Noubar B. AFEYAN
摘要： The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
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公开(公告)号：US20190030129A1
公开(公告)日：2019-01-31
申请号：US15914615
申请日：2018-03-07
申请人： ModernaTX, Inc.
IPC分类号： A61K38/19 , C07K14/685 , A61K31/395 , A61K48/00 , C07K14/62 , A61K31/495 , A61K39/395 , A61K38/28 , A61K38/13 , A61K31/7115 , A61K31/7088 , A61K38/00
摘要： Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
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公开(公告)号：US20200164038A1
公开(公告)日：2020-05-28
申请号：US16525145
申请日：2019-07-29
申请人： ModernaTX, Inc.
发明人： Antonin DE FOUGEROLLES , Kristy M. WOOD , Sayda M. ELBASHIR , Noubar B. AFEYAN , Pedro VALENCIA , Jason P. SCHRUM
IPC分类号： A61K38/19 , C07K14/535 , A61K31/7105 , C12N15/117 , A61K48/00 , C12P21/00 , A61K31/7088 , C07K2/00 , C12N15/88 , A61K9/16 , A61K9/127 , A61K9/00 , C12N15/00 , A61K38/48 , A61K9/14
摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
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公开(公告)号：US20190290742A1
公开(公告)日：2019-09-26
申请号：US16152945
申请日：2018-10-05
申请人： ModernaTX, Inc.
发明人： Tirtha CHAKRABORTY , Stephane BANCEL , Stephen G. HOGE , Atanu ROY , Antonin DE FOUGEROLLES , Noubar B. AFEYAN
摘要： The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
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公开(公告)号：US20180125937A1
公开(公告)日：2018-05-10
申请号：US15621693
申请日：2017-06-13
申请人： ModernaTX, Inc.
发明人： Antonin DE FOUGEROLLES , Kristy M. WOOD , Sayda M. ELBASHIR , Noubar B. AFEYAN , Pedro VALENCIA , Jason P. SCHRUM
IPC分类号： A61K38/19 , C12N15/00 , C12P21/00 , A61K9/14 , A61K9/127 , A61K38/48 , A61K48/00 , C07K14/535 , A61K31/7105 , A61K9/16 , A61K9/00 , A61K31/7088 , C07K2/00 , C12N15/117 , C12N15/88
CPC分类号： A61K38/193 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/1271 , A61K9/1272 , A61K9/14 , A61K9/16 , A61K9/1647 , A61K31/7088 , A61K31/7105 , A61K38/4833 , A61K48/00 , A61K48/0033 , A61K48/0041 , A61K48/005 , A61K48/0066 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
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