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公开(公告)号：US20210077634A1
公开(公告)日：2021-03-18
申请号：US16811648
申请日：2020-03-06
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Justin GUILD
IPC: A61K48/00 , C12N15/85 , C07K14/47 , C07K14/62 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , A61K38/17 , C07K14/435 , C12P21/00 , C07K14/485 , C07H21/02 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K47/54 , A61K9/14 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/515 , C07K16/00
Abstract: The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
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公开(公告)号：US20190314527A1
公开(公告)日：2019-10-17
申请号：US16442168
申请日：2019-06-14
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Jason P. SCHRUM , Justin GUILD
IPC: A61K48/00 , C12N15/85 , C07K14/62 , C07K14/47 , A61K38/19 , A61K38/18 , A61K9/51 , C12P21/00 , A61K47/54 , A61K9/14 , C07K16/00 , C07K14/515 , A61K38/48 , A61K38/21 , A61K38/17 , C12N9/64 , C07H21/02 , C07K14/435 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , C12P13/04 , C12N15/87 , A61K38/45 , C12N9/00 , A61K9/127 , C12N15/11 , C12N9/24 , C12N9/16 , C07K14/005 , C07K14/535 , C07K14/505 , C07K14/705 , C12N15/52 , C12N9/42 , C12N9/10 , C07K14/485 , C12N9/88 , A61K31/7115
Abstract: The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
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公开(公告)号：US20190248864A1
公开(公告)日：2019-08-15
申请号：US16398498
申请日：2019-04-30
Applicant: ModernaTX, Inc.
Inventor： Jeff Lynn ELLSWORTH , Joseph Beene BOLEN , Francine Marie GREGOIRE , Justin GUILD
IPC: C07K14/705
CPC classification number: C07K14/705 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
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4.发明申请公开(公告)号：US20210299278A1
公开(公告)日：2021-09-30
申请号：US17020522
申请日：2020-09-14
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , C12N15/85 , C07K14/47 , C07K14/62 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , A61K38/17 , C07K14/435 , C12P21/00 , C07K14/485 , C07H21/02 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K47/54 , A61K9/14 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/515 , C07K16/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20170368200A1
公开(公告)日：2017-12-28
申请号：US15425645
申请日：2017-02-06
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , A61K9/127 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/10 , C07K16/00 , C07K14/705 , C07K14/62 , C07K14/56 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , A61K47/54 , C07K14/47 , C07K14/435 , C07K14/005 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , C07K14/485 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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Patent Agency Ranking
公开(公告)号：US20240409597A1
公开(公告)日：2024-12-12
申请号：US18543930
申请日：2023-12-18
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Justin GUILD
IPC: C07K14/535 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/50 , A61K31/7088 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/36 , A61K38/44 , A61K38/48 , A61K39/395 , A61K47/10 , A61K47/54 , A61K48/00 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/28 , C07K16/32 , C07K19/00 , C12N9/02 , C12N9/64 , C12N15/85 , C12N15/88
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20210115101A1
公开(公告)日：2021-04-22
申请号：US16665985
申请日：2019-10-28
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: C07K14/535 , A61K48/00 , A61K47/54 , C12N15/88 , A61K9/127 , A61K9/50 , C07K14/47 , A61K31/7088 , C07K19/00 , C12N15/85 , A61K38/18 , A61K38/19 , A61K38/48 , A61K9/14 , A61K38/17 , A61K47/10 , A61K38/21 , A61K38/36 , A61K38/44 , A61K39/395 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/28 , C07K16/32 , C12N9/02 , C12N9/64
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20200247861A1
公开(公告)日：2020-08-06
申请号：US16707998
申请日：2019-12-09
Applicant: ModernaTX, Inc.
Inventor： Antonin DE FOUGEROLLES , Justin GUILD
IPC: C07K14/535 , A61K48/00 , A61K47/60 , C07K14/75 , C12N15/85 , A61K9/14 , C07K14/56 , C07K14/525 , A61K31/7088 , A61K9/00 , C07K14/505 , A61K38/44 , C07K16/28 , A61K38/18 , C07K19/00 , C12N9/02 , C07K14/565 , C07K16/32 , C07K14/47 , C12N15/88 , A61K38/19 , A61K38/48 , C12N9/64 , A61K38/36 , A61K31/7115 , A61K9/127 , C07K14/745 , C07K14/475 , A61K9/50 , A61K38/21 , A61K39/395 , A61K38/17 , A61K47/10
Abstract: The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
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9.发明申请公开(公告)号：US20180311381A1
公开(公告)日：2018-11-01
申请号：US15790246
申请日：2017-10-23
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Kristy M. WOOD , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD
IPC: A61K48/00 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/68 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/12 , C12N9/10 , C12N9/02 , C07K16/40 , C07K16/28 , C07K16/00 , C07K14/745 , C07K14/705 , C07K14/62 , C07K14/61 , C07K14/56 , C07K14/54 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , C07K14/495 , C07K14/485 , C07K14/475 , C07K14/47 , C07K14/435 , C07K14/005 , C07H21/02 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , A61K9/127 , A61K47/54 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20180170990A1
公开(公告)日：2018-06-21
申请号：US15662090
申请日：2017-07-27
Applicant: ModernaTX, Inc.
Inventor： Stephane BANCEL , Tirtha CHAKRABORTY , Antonin DE FOUGEROLLES , Sayda M. ELBASHIR , Matthias JOHN , Atanu ROY , Susan WHORISKEY , Paul HATALA , Jason P. SCHRUM , Kenechi EJEBE , Jeff Lynn ELLSWORTH , Justin GUILD , Ron WEISS , Kristy M. WOOD
IPC: C07K14/535 , A61K48/00 , C07K14/745 , C07K16/28 , C07K16/32 , C12N9/02 , C12N9/64 , A61K38/19 , A61K38/21 , A61K38/36 , A61K38/44 , A61K38/48 , A61K39/395 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/75 , A61K47/10 , A61K38/18 , A61K38/17 , A61K9/14 , C07K14/47 , C12N15/85 , A61K9/50 , A61K9/127
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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