公开(公告)号：US20240009131A1

公开(公告)日：2024-01-11

申请号：US18338485

申请日：2023-06-21

Applicant: ModernaTX, Inc.

Inventor： Joseph Schariter ,  Kimberly Hassett ,  Michael H. Smith ,  Orn Almarsson ,  Luis Brito

IPC: A61K9/19 ,  A61K47/60

CPC classification number: A61K9/19 ,  A61K47/60 ,  B82Y5/00

Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

公开(公告)号：US11905525B2

公开(公告)日：2024-02-20

申请号：US16603111

申请日：2018-04-05

Applicant: ModernaTX, Inc.

Inventor： Luis Brito ,  Gilles Besin

IPC: C12N15/88 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7105 ,  A61K47/12 ,  A61K47/28

CPC classification number: C12N15/88 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/7105 ,  A61K47/12 ,  A61K47/28 ,  C12N2310/141

Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo. These compositions have reduced immune activation resulting in accelerated blood clearance and/or anti-drug antibodies and they have an improved toxicity profile and therapeutic index in vivo.

公开(公告)号：US11744801B2

公开(公告)日：2023-09-05

申请号：US16643037

申请日：2018-08-31

Applicant: ModernaTX, Inc.

Inventor： Joseph Schariter ,  Kimberly Hassett ,  Mike Smith ,  Orn Almarsson ,  Luis Brito

IPC: A61K47/60 ,  B82Y5/00 ,  A61K9/127 ,  A61K9/19

CPC classification number: A61K9/19 ,  A61K47/60 ,  A61K9/127 ,  A61K9/1277 ,  B82Y5/00

Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.