公开(公告)号：US20240009131A1

公开(公告)日：2024-01-11

申请号：US18338485

申请日：2023-06-21

Applicant: ModernaTX, Inc.

Inventor： Joseph Schariter ,  Kimberly Hassett ,  Michael H. Smith ,  Orn Almarsson ,  Luis Brito

IPC: A61K9/19 ,  A61K47/60

CPC classification number: A61K9/19 ,  A61K47/60 ,  B82Y5/00

Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

公开(公告)号：US11744801B2

公开(公告)日：2023-09-05

申请号：US16643037

申请日：2018-08-31

Applicant: ModernaTX, Inc.

Inventor： Joseph Schariter ,  Kimberly Hassett ,  Mike Smith ,  Orn Almarsson ,  Luis Brito

IPC: A61K47/60 ,  B82Y5/00 ,  A61K9/127 ,  A61K9/19

CPC classification number: A61K9/19 ,  A61K47/60 ,  A61K9/127 ,  A61K9/1277 ,  B82Y5/00

Abstract: The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

公开(公告)号：US11969506B2

公开(公告)日：2024-04-30

申请号：US16493814

申请日：2018-03-15

Applicant: ModernaTX, Inc. ,  Oregon State University

Inventor： Siddharth Patel ,  Emily Robinson ,  Anna Brown ,  Orn Almarsson ,  Kerry E. Benenato ,  Staci Sabnis ,  Gaurav Sahay ,  Ashwani Kumar Narayana

IPC: A61K9/51 ,  A61K31/7088 ,  A61K45/06 ,  A61K48/00 ,  C12N15/113

CPC classification number: A61K9/5123 ,  A61K9/5146 ,  A61K31/7088 ,  A61K45/06 ,  A61K48/0033 ,  C12N15/113 ,  C12N2320/32

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11203569B2

公开(公告)日：2021-12-21

申请号：US16493789

申请日：2018-03-15

Applicant: ModernaTX, Inc.

Inventor： Orn Almarsson ,  Eugene Cheung

IPC: C07C229/24 ,  C07C55/07 ,  C07C65/03 ,  C07C227/16 ,  C07C229/12

Abstract: Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.