公开(公告)号：US20180312535A1

公开(公告)日：2018-11-01

申请号：US16008655

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

CPC classification number: C12N15/1089 ,  C07D473/18 ,  C07D473/34 ,  C07H21/00 ,  C07H21/02 ,  C12N2310/3125 ,  C12N2310/313 ,  C12N2310/314 ,  C12N2310/317

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20180291055A1

公开(公告)日：2018-10-11

申请号：US16008658

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20190225644A1

公开(公告)日：2019-07-25

申请号：US15768193

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H19/207

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20180305393A1

公开(公告)日：2018-10-25

申请号：US16008662

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20190218546A1

公开(公告)日：2019-07-18

申请号：US15768199

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

CPC classification number: C12N15/1089 ,  C07D473/18 ,  C07D473/34 ,  C07H21/00 ,  C07H21/02 ,  C12N2310/3125 ,  C12N2310/313 ,  C12N2310/314 ,  C12N2310/317

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.