公开(公告)号：US20190218546A1

公开(公告)日：2019-07-18

申请号：US15768199

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

CPC classification number: C12N15/1089 ,  C07D473/18 ,  C07D473/34 ,  C07H21/00 ,  C07H21/02 ,  C12N2310/3125 ,  C12N2310/313 ,  C12N2310/314 ,  C12N2310/317

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20180312535A1

公开(公告)日：2018-11-01

申请号：US16008655

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

CPC classification number: C12N15/1089 ,  C07D473/18 ,  C07D473/34 ,  C07H21/00 ,  C07H21/02 ,  C12N2310/3125 ,  C12N2310/313 ,  C12N2310/314 ,  C12N2310/317

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20190092828A1

公开(公告)日：2019-03-28

申请号：US16049212

申请日：2018-07-30

Applicant: ModernaTX, Inc.

Inventor： Stephen G. HOGE ,  William Joseph ISSA ,  Edward John MIRACCO ,  Jennifer NELSON ,  John REYNDERS ,  Matthew STANTON

IPC: C07K14/535 ,  C07K14/505 ,  C12P19/34 ,  A61K48/00 ,  C12N9/02 ,  C12P21/02

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

公开(公告)号：US20190255194A1

公开(公告)日：2019-08-22

申请号：US16289947

申请日：2019-03-01

Applicant: ModernaTX, Inc.

Inventor： Atanu ROY ,  Christopher R. CONLEE ,  Antonin DE FOUGEROLLES ,  Andrew W. FRALEY ,  Gabor BUTORA ,  Matthew STANTON

IPC: A61K48/00 ,  C12N15/87 ,  C07D498/22 ,  C07H19/06 ,  C12N15/11 ,  C07D487/16 ,  C07D487/04 ,  C07D473/40 ,  C07D473/38 ,  C07D473/34 ,  C07D473/30 ,  C07D473/18 ,  C07D473/16 ,  C07H19/23 ,  C07H19/20 ,  C07H19/167 ,  C07H19/14 ,  C07H19/10 ,  C07H19/067 ,  C07D239/54 ,  C07D405/04 ,  C07F9/6561 ,  C07F9/6558 ,  C07H19/16 ,  C12N15/67 ,  C07H21/02

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

公开(公告)号：US20190211368A1

公开(公告)日：2019-07-11

申请号：US15768206

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Edward John MIRACCO

IPC: C12P19/34 ,  C12N15/113 ,  C07H21/02 ,  C12N15/10 ,  C12N9/12 ,  A61K31/7125

CPC classification number: C12P19/34 ,  A61K31/7125 ,  C07H21/02 ,  C12N9/1247 ,  C12N15/1096 ,  C12N15/113 ,  C12N2310/317 ,  C12Y207/07006

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20180291055A1

公开(公告)日：2018-10-11

申请号：US16008658

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20190225644A1

公开(公告)日：2019-07-25

申请号：US15768193

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H19/207

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20180305393A1

公开(公告)日：2018-10-25

申请号：US16008662

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor BUTORA ,  Matthew STANTON ,  Thomas STEELE

IPC: C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.