公开(公告)号：US20190382774A1

公开(公告)日：2019-12-19

申请号：US16300223

申请日：2017-05-18

Applicant: ModernaTX, Inc.

Inventor： Stephen G. HOGE ,  Kerry BENENATO ,  Vladimir PRESNYAK ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Staci SABNIS ,  William BUTCHER

IPC: C12N15/67 ,  A61K31/7115 ,  A61K48/00

Abstract: The invention related to polyribonucleotides comprising an open reading frame of linked nucleosides encoding a polypeptide of interest (e.g., a therapeutic polypeptide), isoforms thereof, functional fragments thereof, and fusion proteins comprising the polypeptide. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the invention provides sequence-optimized polyribonucleotides comprising nucleotides encoding the sequence of the polypeptide of interest, or sequence having high sequence identity with those sequence optimized polyribonucleotides.

公开(公告)号：US20210198200A1

公开(公告)日：2021-07-01

申请号：US16620666

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: C07D211/28 ,  C07D207/09 ,  A61K9/51 ,  A61K47/60

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20180333366A1

公开(公告)日：2018-11-22

申请号：US16004850

申请日：2018-06-11

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: A61K9/51 ,  C07D295/185 ,  A61K38/18

CPC classification number: A61K9/5123 ,  A61K38/1808 ,  A61K38/1816 ,  C07D211/14 ,  C07D211/16 ,  C07D295/13 ,  C07D295/185

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20240318187A1

公开(公告)日：2024-09-26

申请号：US18477788

申请日：2023-09-29

Applicant: ModernaTX, Inc.

Inventor： Stephen G. HOGE ,  Kerry BENENATO ,  Vladimir PRESNYAK ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Staci SABNIS ,  William BUTCHER

IPC: C12N15/67 ,  A61K31/7115 ,  A61K48/00

CPC classification number: C12N15/67 ,  A61K31/7115 ,  A61K48/0066 ,  C12N2800/22

Abstract: The invention related to polyribonucleotides comprising an open reading frame of linked nucleosides encoding a polypeptide of interest (e.g., a therapeutic polypeptide), isoforms thereof, functional fragments thereof, and fusion proteins comprising the polypeptide. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the invention provides sequence-optimized polyribonucleotides comprising nucleotides encoding the sequence of the polypeptide of interest, or sequence having high sequence identity with those sequence optimized polyribonucleotides.

公开(公告)号：US20210161829A1

公开(公告)日：2021-06-03

申请号：US16991196

申请日：2020-08-12

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: A61K9/51 ,  C07D295/185 ,  C07D211/16 ,  C07D295/13 ,  C07D211/14 ,  A61K38/18 ,  A61K47/22 ,  A61K48/00 ,  C07D241/04

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20180369419A1

公开(公告)日：2018-12-27

申请号：US16065067

申请日：2016-12-22

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: A61K48/00 ,  A61K47/22 ,  C07D241/04

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.