公开(公告)号：US20080254050A1

公开(公告)日：2008-10-16

申请号：US11787522

申请日：2007-04-17

申请人： Monica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernandez Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vazquez Blomquist

发明人： Monica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernandez Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vazquez Blomquist

IPC分类号： A61K39/00 ,  A61P37/00

CPC分类号： C07K14/715 ,  A61K38/1858 ,  A61K38/1866 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55594 ,  C07K14/515 ,  C07K14/52 ,  C07K14/71

摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。

公开(公告)号：US20100047265A1

公开(公告)日：2010-02-25

申请号：US12612455

申请日：2009-11-04

申请人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

发明人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

IPC分类号： A61K39/00 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07K14/715 ,  A61K38/1858 ,  A61K38/1866 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55594 ,  C07K14/515 ,  C07K14/52 ,  C07K14/71

摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。

公开(公告)号：US08883724B2

公开(公告)日：2014-11-11

申请号：US12612455

申请日：2009-11-04

申请人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

发明人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

IPC分类号： A61K38/18 ,  A61K39/395 ,  C07K14/475 ,  C07K16/00 ,  C07K14/515 ,  C07K14/52 ,  A61K48/00 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

CPC分类号： C07K14/715 ,  A61K38/1858 ,  A61K38/1866 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55594 ,  C07K14/515 ,  C07K14/52 ,  C07K14/71

摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。

公开(公告)号：US07556809B2

公开(公告)日：2009-07-07

申请号：US10511384

申请日：2003-04-11

申请人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vázquez Blomquist

发明人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vázquez Blomquist

IPC分类号： A61K39/095 ,  A61K39/39 ,  A61K38/18 ,  A61K38/04 ,  A61K39/395 ,  C07K4/12

CPC分类号： C07K14/715 ,  A61K38/1858 ,  A61K38/1866 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55594 ,  C07K14/515 ,  C07K14/52 ,  C07K14/71

摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。