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公开(公告)号：US20230390332A1
公开(公告)日：2023-12-07
申请号：US18364319
申请日：2023-08-02
发明人： Ziv Rotfogel , Keren Ben-Yaakov , Michal Simon
摘要： Methods for treatment of cornea epithelium pathologies and conditions, which may benefit from treatment of mitochondrial dysfunction, mitochondrial destruction and/or mitochondrial depletion in the eye, are disclosed. These methods comprise the transplantation of viable exogenous, isolated mitochondria to the cornea, for example, by topical application of designated eyedrops.
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公开(公告)号：US20220168358A1
公开(公告)日：2022-06-02
申请号：US17594141
申请日：2020-04-03
发明人： Ziv Rotfogel , Keren Ben-Yaakov , Michal Simon
IPC分类号： A61K35/407 , A61P27/02
摘要： Methods for treatment of ocular diseases and conditions associated with mitochondrial dysfunction, mitochondrial destruction and/or mitochondrial depletion in the eye, are disclosed. These methods comprise the transplantation of viable exogenous, isolated mitochondria to ocular tissues. Mitochondrial transplantation is effective in treatment of, e.g., an ocular manifestation of a disease or disorder in a subject, an ophthalmic disease, disorder or condition associated with mitochondrial dysfunction, and/or an ocular ischemic insult in a subject.
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